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PRKDC

Summary: This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
protein kinase, DNA-activated, catalytic subunit	MIM:600899	Ensembl:ENSG00000253729	HGNC:HGNC:9413	PA33776	8q11.21

Gene Categories:

TRANSCRIPTION FACTOR COMPLEX TRANSCRIPTION FACTOR BINDING TUMOR SUPPRESSOR KINASE PHOSPHATIDYLINOSITOL 3 KINASE CLINICALLY ACTIONABLE SERINE THREONINE KINASE DNA REPAIR DRUGGABLE GENOME

GO terms in PRKDC

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IDA	GO:0003690	double-stranded DNA binding
MF	HDA	GO:0003723	RNA binding
MF	IDA	GO:0004672	protein kinase activity
MF	IMP	GO:0004672	protein kinase activity
MF	IDA	GO:0004674	protein serine/threonine kinase activity
MF	TAS	GO:0004674	protein serine/threonine kinase activity
MF	IDA	GO:0004677	DNA-dependent protein kinase activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005524	ATP binding
MF	IPI	GO:0008134	transcription factor binding
MF	IBA	GO:0016301	kinase activity
MF	IEA	GO:0019899	enzyme binding
MF	IPI	GO:0019904	protein domain specific binding
CC	HDA	GO:0000784	nuclear chromosome, telomeric region
CC	IBA	GO:0005634	nucleus
CC	IDA	GO:0005634	nucleus
CC	IDA	GO:0005654	nucleoplasm
CC	TAS	GO:0005654	nucleoplasm
CC	IDA	GO:0005667	transcription factor complex
CC	IDA	GO:0005730	nucleolus
CC	TAS	GO:0005829	cytosol
CC	IDA	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex
CC	HDA	GO:0016020	membrane
CC	IMP	GO:0032991	protein-containing complex
CC	IDA	GO:0032993	protein-DNA complex
CC	IDA	GO:0070419	nonhomologous end joining complex
BP	IEA	GO:0001756	somitogenesis
BP	ISS	GO:0001933	negative regulation of protein phosphorylation
BP	IDA	GO:0002218	activation of innate immune response
BP	IEA	GO:0002326	B cell lineage commitment
BP	IEA	GO:0002328	pro-B cell differentiation
BP	IEA	GO:0002360	T cell lineage commitment
BP	IEA	GO:0002638	negative regulation of immunoglobulin production
BP	IBA	GO:0006281	DNA repair
BP	IMP	GO:0006302	double-strand break repair
BP	TAS	GO:0006303	double-strand break repair via nonhomologous end joining
BP	TAS	GO:0006464	cellular protein modification process
BP	IMP	GO:0006468	protein phosphorylation
BP	IEA	GO:0007420	brain development
BP	IEA	GO:0007507	heart development
BP	IMP	GO:0008283	cell proliferation
BP	IEA	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
BP	IEA	GO:0010332	response to gamma radiation
BP	IEA	GO:0014823	response to activity
BP	IMP	GO:0016233	telomere capping
BP	TAS	GO:0016567	protein ubiquitination
BP	IDA	GO:0018105	peptidyl-serine phosphorylation
BP	IEA	GO:0031648	protein destabilization
BP	TAS	GO:0032481	positive regulation of type I interferon production
BP	IMP	GO:0032869	cellular response to insulin stimulus
BP	IEA	GO:0033077	T cell differentiation in thymus
BP	IEA	GO:0033152	immunoglobulin V(D)J recombination
BP	IEA	GO:0033153	T cell receptor V(D)J recombination
BP	IEA	GO:0035234	ectopic germ cell programmed cell death
BP	ISS	GO:0042752	regulation of circadian rhythm
BP	IEA	GO:0043065	positive regulation of apoptotic process
BP	IMP	GO:0043066	negative regulation of apoptotic process
BP	IEA	GO:0045087	innate immune response
BP	IMP	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	IEA	GO:0048146	positive regulation of fibroblast proliferation
BP	IEA	GO:0048511	rhythmic process
BP	IEA	GO:0048536	spleen development
BP	IEA	GO:0048538	thymus development
BP	IEA	GO:0048639	positive regulation of developmental growth
BP	IMP	GO:0048660	regulation of smooth muscle cell proliferation
BP	IMP	GO:0072431	signal transduction involved in mitotic G1 DNA damage checkpoint
BP	TAS	GO:0097681	double-strand break repair via alternative nonhomologous end joining
BP	IEA	GO:2000773	negative regulation of cellular senescence
BP	IEA	GO:2001229	negative regulation of response to gamma radiation

Gene expression in normal tissue: PRKDC

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRKDC

Database	Pathway ID	Pathway Des.
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-1834941	STING mediated induction of host immune responses
reactome	R-HSA-1834949	Cytosolic sensors of pathogen-associated DNA
reactome	R-HSA-3270619	IRF3-mediated induction of type I IFN
reactome	R-HSA-392499	Metabolism of proteins
reactome	R-HSA-5693532	DNA Double-Strand Break Repair
reactome	R-HSA-5693571	Nonhomologous End-Joining (NHEJ)
reactome	R-HSA-597592	Post-translational protein modification
reactome	R-HSA-73894	DNA Repair
reactome	R-HSA-8852135	Protein ubiquitination
reactome	R-HSA-8866654	E3 ubiquitin ligases ubiquitinate target proteins
biocarta	faspathway	fas signaling pathway (cd95)
biocarta	g2pathway	cell cycle: g2/m checkpoint
biocarta	hivnefpathway	hiv-1 nef: negative effector of fas and tnf
kegg	hsa03450	Non-homologous end-joining - Homo sapiens (human)
kegg	hsa04110	Cell cycle - Homo sapiens (human)
pid	ar_pathway	Coregulation of Androgen receptor activity
pid	bard1pathway	BARD1 signaling events
pid	dnapk_pathway	DNA-PK pathway in nonhomologous end joining
pid	pi3kciaktpathway	Class I PI3K signaling events mediated by Akt
wikipathways	WP1530	miRNA Regulation of DNA Damage Response
wikipathways	WP179	Cell Cycle
wikipathways	WP2446	Retinoblastoma (RB) in Cancer
wikipathways	WP314	Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation
wikipathways	WP3651	Pathways Affected in Adenoid Cystic Carcinoma
wikipathways	WP3878	ATM Signaling Network in Development and Disease
wikipathways	WP438	Non-homologous end joining
wikipathways	WP707	DNA Damage Response

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD64	Parbendazole	1
iGMDRD451	Serdemetan	4
iGMDRD74	Idarubicin	3
iGMDRD399	Selumetinib	3
iGMDRD188	Piperlongumine	3
iGMDRD398	Sepantronium	3
iGMDRD780	PP-30	1
iGMDRD562	Navitoclax	3
iGMDRD506	Fedratinib	5
iGMDRD782	DC-45-A2	4
iGMDRD187	BRD9876	2
iGMDRD294	Batimastat	2
iGMDRD801	2,4-dideoxy-DC-45-A2	2
iGMDRD138	PX 12	3
iGMDRD679	Bistramide A	2
iGMDRD375	GW-405833	2
iGMDRD201	SKI II	3
iGMDRD446	LY 2183240	2
iGMDRD61	Kinetin riboside	2
iGMDRD779	PRL-3 Inhibitor I	1
iGMDRD494	Neopeltolide	6
iGMDRD126	Tipifarnib	3
iGMDRD420	Leucascandrolide A	6
iGMDRD300	Tozasertib	1
iGMDRD886	Compound 1541A	2
iGMDRD286	Nsc 632839	5
iGMDRD414	MST-312	2
iGMDRD158	NSC141540	4
iGMDRD202	Curcumin	3
iGMDRD137	Indisulam	4
iGMDRD103	SN-38	1
iGMDRD154	NSC23766	4
iGMDRD237	ABT-751	2
iGMDRD351	GW843682X	1
iGMDRD314	Tanespimycin	3
iGMDRD150	RITA	2
iGMDRD560	MK-2206	4
iGMDRD405	PIK-75	1
iGMDRD84	Lovastatin acid	1
iGMDRD512	nutlin 3	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRKDC

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.