SEARCH

HOME / SEARCH / PRKDC

PRKDC

Summary: This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010].

Loading, please wait...

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameprotein kinase, DNA-activated, catalytic subunit OMIM IDMIM:600899 Ensembl IDEnsembl:ENSG00000253729 HGNC IDHGNC:HGNC:9413 PHARMGKB IDPA33776 Map Location8q11.21

Gene Categories:

TRANSCRIPTION FACTOR COMPLEX TRANSCRIPTION FACTOR BINDING TUMOR SUPPRESSOR KINASE PHOSPHATIDYLINOSITOL 3 KINASE CLINICALLY ACTIONABLE SERINE THREONINE KINASE DNA REPAIR DRUGGABLE GENOME

GO terms in PRKDC

Loading, please wait...

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IDA	GO:0003690	double-stranded DNA binding
MF	HDA	GO:0003723	RNA binding
MF	IDA	GO:0004672	protein kinase activity
MF	IMP	GO:0004672	protein kinase activity
MF	IDA	GO:0004674	protein serine/threonine kinase activity
MF	TAS	GO:0004674	protein serine/threonine kinase activity

Showing 1 to 6 of 69 rows rows per page

Gene expression in normal tissue: PRKDC

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRKDC

Loading, please wait...

Database	Pathway ID	Pathway Des.
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-1834941	STING mediated induction of host immune responses
reactome	R-HSA-1834949	Cytosolic sensors of pathogen-associated DNA
reactome	R-HSA-3270619	IRF3-mediated induction of type I IFN
reactome	R-HSA-392499	Metabolism of proteins

Showing 1 to 6 of 29 rows rows per page

Gene-Drug: Aster Plot

Loading, please wait...

Drug ID	Drug Name	Model Num.
iGMDRD64	Parbendazole	1
iGMDRD451	Serdemetan	4
iGMDRD74	Idarubicin	3
iGMDRD399	Selumetinib	3

Showing 1 to 4 of 40 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRKDC

Loading, please wait...

	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
No matching records found

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.