FANCB
Summary: This gene encodes a member of the Fanconi anemia complementation group B. This protein is assembled into a nucleoprotein complex that is involved in the repair of DNA lesions. Mutations in this gene can cause chromosome instability and VACTERL syndrome with hydrocephalus. [provided by RefSeq, Apr 2016].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:300515 Ensembl IDEnsembl:ENSG00000181544 HGNC IDHGNC:HGNC:3583 PHARMGKB IDPA27996 Map LocationXp22.2 |
Gene Categories:
DNA REPAIRGO terms in FANCB
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IPI | GO:0005515 | protein binding |
BP | TAS | GO:0036297 | interstrand cross-link repair |
BP | IBA | GO:1905168 | positive regulation of double-strand break repair via homologous recombination |
BP | IBA | GO:1990414 | replication-born double-strand break repair via sister chromatid exchange |
BP | IBA | GO:2000042 | negative regulation of double-strand break repair via homologous recombination |
CC | TAS | GO:0005654 | nucleoplasm |
Gene expression in normal tissue: FANCB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FANCB
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Database | Pathway ID | Pathway Des. |
---|---|---|
pid | fanconi_pathway | Fanconi anemia pathway |
kegg | hsa03460 | Fanconi anemia pathway - Homo sapiens (human) |
reactome | R-HSA-6783310 | Fanconi Anemia Pathway |
reactome | R-HSA-73894 | DNA Repair |
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Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in FANCB
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |