FANCB
Summary: This gene encodes a member of the Fanconi anemia complementation group B. This protein is assembled into a nucleoprotein complex that is involved in the repair of DNA lesions. Mutations in this gene can cause chromosome instability and VACTERL syndrome with hydrocephalus. [provided by RefSeq, Apr 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| FA complementation group B | MIM:300515 | Ensembl:ENSG00000181544 | HGNC:HGNC:3583 | PA27996 | Xp22.2 |
Gene Categories:
DNA REPAIRGO terms in FANCB
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| BP | TAS | GO:0036297 | interstrand cross-link repair |
| BP | IBA | GO:1905168 | positive regulation of double-strand break repair via homologous recombination |
| BP | IBA | GO:1990414 | replication-born double-strand break repair via sister chromatid exchange |
| BP | IBA | GO:2000042 | negative regulation of double-strand break repair via homologous recombination |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0043240 | Fanconi anaemia nuclear complex |
| CC | IDA | GO:0043240 | Fanconi anaemia nuclear complex |
Gene expression in normal tissue: FANCB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FANCB
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | fanconi_pathway | Fanconi anemia pathway |
| kegg | hsa03460 | Fanconi anemia pathway - Homo sapiens (human) |
| reactome | R-HSA-6783310 | Fanconi Anemia Pathway |
| reactome | R-HSA-73894 | DNA Repair |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD300 | Tozasertib | 1 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD171 | Pemetrexed | 4 |
| iGMDRD5 | Tyrphostin AG 1478 | 1 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD137 | Indisulam | 1 |
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD177 | Teniposide | 1 |
| iGMDRD314 | Tanespimycin | 2 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD126 | Tipifarnib | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FANCB
CLASSFICATION
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