FANCB

Summary: This gene encodes a member of the Fanconi anemia complementation group B. This protein is assembled into a nucleoprotein complex that is involved in the repair of DNA lesions. Mutations in this gene can cause chromosome instability and VACTERL syndrome with hydrocephalus. [provided by RefSeq, Apr 2016].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameFA complementation group B
OMIM IDMIM:300515
Ensembl IDEnsembl:ENSG00000181544
HGNC IDHGNC:HGNC:3583
PHARMGKB IDPA27996
Map LocationXp22.2

Gene Categories:

DNA REPAIR

GO terms in FANCB


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005515 protein binding
BP TAS GO:0036297 interstrand cross-link repair
BP IBA GO:1905168 positive regulation of double-strand break repair via homologous recombination
BP IBA GO:1990414 replication-born double-strand break repair via sister chromatid exchange
BP IBA GO:2000042 negative regulation of double-strand break repair via homologous recombination
CC TAS GO:0005654 nucleoplasm
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Gene expression in normal tissue: FANCB

Gene-model tissue-cancer distribution: Bubble Plot

BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 28undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 28

Gene-drug pathway distribution

undefined15Ferroptosis1Protein stability and degradation1DNA replication1Other, kinases1Mitosis1p53 pathway1One carbon pool by folate1

Pathways in FANCB


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Database
Pathway ID
Pathway Des.
pid fanconi_pathway Fanconi anemia pathway
kegg hsa03460 Fanconi anemia pathway - Homo sapiens (human)
reactome R-HSA-6783310 Fanconi Anemia Pathway
reactome R-HSA-73894 DNA Repair
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD451 Serdemetan 3
iGMDRD300 Tozasertib 1
iGMDRD246 NPC26 3
iGMDRD506 Fedratinib 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FANCB

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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