BUB1B
Summary: This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| BUB1 mitotic checkpoint serine/threonine kinase B | MIM:602860 | Ensembl:ENSG00000156970 | HGNC:HGNC:1149 | PA82 | 15q15.1 |
GO terms in BUB1B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0000776 | kinetochore |
| CC | IDA | GO:0000776 | kinetochore |
| CC | NAS | GO:0000776 | kinetochore |
| CC | TAS | GO:0000776 | kinetochore |
| CC | IDA | GO:0000777 | condensed chromosome kinetochore |
| CC | IBA | GO:0000778 | condensed nuclear chromosome kinetochore |
| CC | IDA | GO:0000940 | condensed chromosome outer kinetochore |
| CC | TAS | GO:0005680 | anaphase-promoting complex |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005815 | microtubule organizing center |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| CC | NAS | GO:0051233 | spindle midzone |
| BP | NAS | GO:0000278 | mitotic cell cycle |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IEA | GO:0007091 | metaphase/anaphase transition of mitotic cell cycle |
| BP | TAS | GO:0007093 | mitotic cell cycle checkpoint |
| BP | IBA | GO:0007094 | mitotic spindle assembly checkpoint |
| BP | TAS | GO:0008283 | cell proliferation |
| BP | TAS | GO:0031145 | anaphase-promoting complex-dependent catabolic process |
| BP | IPI | GO:0034501 | protein localization to kinetochore |
| BP | IEA | GO:0051301 | cell division |
| BP | IBA | GO:0051754 | meiotic sister chromatid cohesion, centromeric |
| MF | IBA | GO:0004672 | protein kinase activity |
| MF | NAS | GO:0004672 | protein kinase activity |
| MF | IEA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
Gene expression in normal tissue: BUB1B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BUB1B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP179 | Cell Cycle |
| wikipathways | WP4240 | Regulation of sister chromatid separation at the metaphase-anaphase transition |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| pid | plk1_pathway | PLK1 signaling events |
| reactome | R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| reactome | R-HSA-141424 | Amplification of signal from the kinetochores |
| reactome | R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex |
| reactome | R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins |
| reactome | R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A |
| reactome | R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase |
| reactome | R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins |
| reactome | R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins |
| reactome | R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A |
| reactome | R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-2467813 | Separation of Sister Chromatids |
| reactome | R-HSA-2500257 | Resolution of Sister Chromatid Cohesion |
| reactome | R-HSA-2555396 | Mitotic Metaphase and Anaphase |
| reactome | R-HSA-453276 | Regulation of mitotic cell cycle |
| reactome | R-HSA-5663220 | RHO GTPases Activate Formins |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68882 | Mitotic Anaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69618 | Mitotic Spindle Checkpoint |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD351 | GW843682X | 6 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD116 | CD437 | 2 |
| iGMDRD150 | RITA | 2 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD882 | CIL41 | 2 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD300 | Tozasertib | 5 |
| iGMDRD322 | FK 866 | 1 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD446 | LY 2183240 | 5 |
| iGMDRD71 | Sparfosic acid | 3 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD433 | Lexibulin | 1 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD144 | NSC95397 | 6 |
| iGMDRD483 | SCH-529074 | 2 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD188 | Piperlongumine | 6 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD506 | Fedratinib | 7 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD369 | TGX-115 | 1 |
| iGMDRD23 | Gossypol | 6 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD294 | Batimastat | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BUB1B
CLASSFICATION
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