BUB1B

Summary: This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameBUB1 mitotic checkpoint serine/threonine kinase B
OMIM IDMIM:602860
Ensembl IDEnsembl:ENSG00000156970
HGNC IDHGNC:HGNC:1149
PHARMGKB IDPA82
Map Location15q15.1

GO terms in BUB1B


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0000776 kinetochore
CC IDA GO:0000776 kinetochore
CC NAS GO:0000776 kinetochore
CC TAS GO:0000776 kinetochore
CC IDA GO:0000777 condensed chromosome kinetochore
CC IBA GO:0000778 condensed nuclear chromosome kinetochore
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Gene expression in normal tissue: BUB1B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined30Biosynthesis of secondary metabolites1One carbon pool by folate1Leukocyte transendothelial migration1Apoptosis regulation1Longevity regulating pathway1Mitosis1Metabolism1Cell cycle1Other, kinases1

Pathways in BUB1B


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Database
Pathway ID
Pathway Des.
wikipathways WP179 Cell Cycle
wikipathways WP4240 Regulation of sister chromatid separation at the metaphase-anaphase transition
kegg hsa04110 Cell cycle - Homo sapiens (human)
kegg hsa05166 HTLV-I infection - Homo sapiens (human)
pid plk1_pathway PLK1 signaling events
reactome R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD351 GW843682X 6
iGMDRD237 ABT-751 2
iGMDRD123 Isoevodiamine 2
iGMDRD512 nutlin 3 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BUB1B

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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