CSF3

Summary: The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namecolony stimulating factor 3
OMIM IDMIM:138970
Ensembl IDEnsembl:ENSG00000108342
HGNC IDHGNC:HGNC:2438
PHARMGKB IDPA26941
Map Location17q21.1

GO terms in CSF3


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Term Type
Evidence Type
GO Term ID
GO Des.
CC TAS GO:0005576 extracellular region
CC IBA GO:0005615 extracellular space
BP IEA GO:0006955 immune response
BP TAS GO:0007275 multicellular organism development
BP IBA GO:0008284 positive regulation of cell proliferation
BP IEA GO:0010469 regulation of signaling receptor activity
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Gene expression in normal tissue: CSF3

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: ADENOCARCINOMA model num: 22undefinedtissue: undefined cancer: PANCAN model num: 54LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 14BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 7

Gene-drug pathway distribution

undefined17PI3K/MTOR signaling2Other, kinases1Apoptosis regulation1Biosynthesis of secondary metabolites1DNA replication1Cell cycle1RTK signaling1

Pathways in CSF3


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Database
Pathway ID
Pathway Des.
wikipathways WP2849 Hematopoietic Stem Cell Differentiation
wikipathways WP3624 Lung fibrosis
wikipathways WP3932 Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathways WP4063 Interleukin-10 signaling
wikipathways WP4172 PI3K-Akt Signaling Pathway
wikipathways WP530 Cytokines and Inflammatory Response
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD560 MK-2206 3
iGMDRD144 NSC95397 5
iGMDRD512 nutlin 3 3
iGMDRD1008 SR-II-138A 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CSF3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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