CSF3
Summary: The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| colony stimulating factor 3 | MIM:138970 | Ensembl:ENSG00000108342 | HGNC:HGNC:2438 | PA26941 | 17q21.1 |
GO terms in CSF3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| BP | IEA | GO:0006955 | immune response |
| BP | TAS | GO:0007275 | multicellular organism development |
| BP | IBA | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IDA | GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling |
| BP | NAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IDA | GO:0030838 | positive regulation of actin filament polymerization |
| BP | NAS | GO:0030851 | granulocyte differentiation |
| BP | IDA | GO:0032092 | positive regulation of protein binding |
| BP | IDA | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| BP | IEA | GO:0045471 | response to ethanol |
| BP | IBA | GO:0045639 | positive regulation of myeloid cell differentiation |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| BP | IDA | GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| BP | IDA | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | IEA | GO:0071222 | cellular response to lipopolysaccharide |
| BP | IDA | GO:0071345 | cellular response to cytokine stimulus |
| BP | IEA | GO:1901215 | negative regulation of neuron death |
| BP | IDA | GO:2000251 | positive regulation of actin cytoskeleton reorganization |
| MF | IBA | GO:0005125 | cytokine activity |
| MF | IDA | GO:0005125 | cytokine activity |
| MF | NAS | GO:0005125 | cytokine activity |
| MF | IBA | GO:0005130 | granulocyte colony-stimulating factor receptor binding |
| MF | IBA | GO:0008083 | growth factor activity |
| MF | IPI | GO:0019899 | enzyme binding |
Gene expression in normal tissue: CSF3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CSF3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2849 | Hematopoietic Stem Cell Differentiation |
| wikipathways | WP3624 | Lung fibrosis |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4063 | Interleukin-10 signaling |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP530 | Cytokines and Inflammatory Response |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
| kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| kegg | hsa05144 | Malaria - Homo sapiens (human) |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-449836 | Other interleukin signaling |
| reactome | R-HSA-6783783 | Interleukin-10 signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD144 | NSC95397 | 5 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD434 | BMS-536924 | 5 |
| iGMDRD415 | LE-135 | 3 |
| iGMDRD77 | Itraconazole | 5 |
| iGMDRD267 | Oligomycin A | 4 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD491 | TAE-684 | 1 |
| iGMDRD5 | Tyrphostin AG 1478 | 1 |
| iGMDRD255 | SB225002 | 11 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD286 | Nsc 632839 | 8 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD506 | Fedratinib | 9 |
| iGMDRD366 | PI-103 | 9 |
| iGMDRD398 | Sepantronium | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CSF3
CLASSFICATION
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