PRPF4B
Summary: Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs). [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| pre-mRNA processing factor 4B | MIM:602338 | Ensembl:ENSG00000112739 | HGNC:HGNC:17346 | PA38447 | 6p25.2 |
GO terms in PRPF4B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0004672 | protein kinase activity |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| CC | IBA | GO:0005634 | nucleus |
| CC | IEA | GO:0005694 | chromosome |
| CC | IDA | GO:0016607 | nuclear speck |
| CC | IDA | GO:0071013 | catalytic step 2 spliceosome |
| BP | IC | GO:0000398 | mRNA splicing, via spliceosome |
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0008380 | RNA splicing |
Gene expression in normal tissue: PRPF4B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRPF4B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_TCR | TCR |
| wikipathways | WP411 | mRNA Processing |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD499 | PDMP | 1 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD424 | Tamatinib | 4 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD512 | nutlin 3 | 5 |
| iGMDRD584 | VER 155008 | 2 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD366 | PI-103 | 1 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD434 | BMS-536924 | 9 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD483 | SCH-529074 | 2 |
| iGMDRD781 | Sirolimus | 4 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD599 | Salermide | 2 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD74 | Idarubicin | 4 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD398 | Sepantronium | 5 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD318 | PAC-1 | 4 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD255 | SB225002 | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRPF4B
CLASSFICATION
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