PRPF4B

Summary: Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs). [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namepre-mRNA processing factor 4B
OMIM IDMIM:602338
Ensembl IDEnsembl:ENSG00000112739
HGNC IDHGNC:HGNC:17346
PHARMGKB IDPA38447
Map Location6p25.2

GO terms in PRPF4B


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Term Type
Evidence Type
GO Term ID
GO Des.
MF HDA GO:0003723 RNA binding
MF IBA GO:0004672 protein kinase activity
MF TAS GO:0004672 protein kinase activity
MF IBA GO:0004693 cyclin-dependent protein serine/threonine kinase activity
MF IPI GO:0005515 protein binding
MF IEA GO:0005524 ATP binding
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Gene expression in normal tissue: PRPF4B

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 21undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 56undefinedtissue: undefined cancer: ADENOCARCINOMA model num: 3BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 10UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 16OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 10

Gene-drug pathway distribution

undefined26Apoptosis regulation3PI3K/MTOR signaling2ERK MAPK signaling1Other, kinases1Biosynthesis of secondary metabolites1IGFR signaling1Mitosis1Chromatin histone acetylation1Proteasome1

Pathways in PRPF4B


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Database
Pathway ID
Pathway Des.
netpath Pathway_EGFR1 EGFR1
netpath Pathway_TCR TCR
wikipathways WP411 mRNA Processing
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD123 Isoevodiamine 3
iGMDRD154 NSC23766 3
iGMDRD57 Chloropentafluorobenzene 2
iGMDRD499 PDMP 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRPF4B

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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