CASP10
Summary: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| caspase 10 | MIM:601762 | Ensembl:ENSG00000003400 | HGNC:HGNC:1500 | PA26084 | 2q33.1 |
GO terms in CASP10
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0031265 | CD95 death-inducing signaling complex |
| CC | IDA | GO:0097342 | ripoptosome |
| BP | IEA | GO:0006508 | proteolysis |
| BP | IBA | GO:0006915 | apoptotic process |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | IBA | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | TAS | GO:0007166 | cell surface receptor signaling pathway |
| BP | TAS | GO:0042981 | regulation of apoptotic process |
| BP | IMP | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | TAS | GO:0097190 | apoptotic signaling pathway |
| BP | IBA | GO:0097194 | execution phase of apoptosis |
| MF | IDA | GO:0004197 | cysteine-type endopeptidase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IPI | GO:0035877 | death effector domain binding |
| MF | IBA | GO:0097153 | cysteine-type endopeptidase activity involved in apoptotic process |
| MF | IBA | GO:0097199 | cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
| MF | IMP | GO:0097199 | cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
| MF | IBA | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis |
Gene expression in normal tissue: CASP10
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CASP10
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP314 | Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP3802 | TP53 Regulates Transcription of Cell Death Genes |
| wikipathways | WP3865 | RIG-I-like Receptor Signaling |
| pid | caspase_pathway | Caspase Cascade in Apoptosis |
| pid | faspathway | FAS (CD95) signaling pathway |
| pid | p53downstreampathway | Direct p53 effectors |
| pid | trail_pathway | TRAIL signaling pathway |
| netpath | Pathway_TNFalpha | TNFalpha |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04622 | RIG-I-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| biocarta | caspasepathway | caspase cascade in apoptosis |
| biocarta | deathpathway | induction of apoptosis through dr3 and dr4/5 death receptors |
| biocarta | faspathway | fas signaling pathway (cd95) |
| biocarta | irespathway | internal ribosome entry pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes |
| reactome | R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-75157 | FasL/ CD95L signaling |
| reactome | R-HSA-75158 | TRAIL signaling |
| reactome | R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD213 | SMR000068650 | 3 |
| iGMDRD267 | Oligomycin A | 1 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD100 | Zebularine | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CASP10
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