CCL4
Summary: The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. [provided by RefSeq, Dec 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| C-C motif chemokine ligand 4 | MIM:182284 | Ensembl:ENSG00000275302 | HGNC:HGNC:10630 | PA35562 | 17q12 |
GO terms in CCL4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0002548 | monocyte chemotaxis |
| BP | IBA | GO:0006954 | inflammatory response |
| BP | TAS | GO:0006955 | immune response |
| BP | TAS | GO:0007155 | cell adhesion |
| BP | TAS | GO:0007163 | establishment or maintenance of cell polarity |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IBA | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0007267 | cell-cell signaling |
| BP | TAS | GO:0009615 | response to virus |
| BP | IDA | GO:0009636 | response to toxic substance |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IBA | GO:0030593 | neutrophil chemotaxis |
| BP | IBA | GO:0043547 | positive regulation of GTPase activity |
| BP | IDA | GO:0043922 | negative regulation by host of viral transcription |
| BP | IBA | GO:0048245 | eosinophil chemotaxis |
| BP | IBA | GO:0048247 | lymphocyte chemotaxis |
| BP | IBA | GO:0050729 | positive regulation of inflammatory response |
| BP | IMP | GO:0050850 | positive regulation of calcium-mediated signaling |
| BP | IDA | GO:0051928 | positive regulation of calcium ion transport |
| BP | IBA | GO:0070098 | chemokine-mediated signaling pathway |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IBA | GO:0071346 | cellular response to interferon-gamma |
| BP | IBA | GO:0071347 | cellular response to interleukin-1 |
| BP | IBA | GO:0071356 | cellular response to tumor necrosis factor |
| BP | IDA | GO:2000503 | positive regulation of natural killer cell chemotaxis |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| MF | TAS | GO:0005125 | cytokine activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008009 | chemokine activity |
| MF | IPI | GO:0031726 | CCR1 chemokine receptor binding |
| MF | IPI | GO:0031730 | CCR5 chemokine receptor binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IBA | GO:0048020 | CCR chemokine receptor binding |
Gene expression in normal tissue: CCL4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CCL4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP3624 | Lung fibrosis |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP4063 | Interleukin-10 signaling |
| wikipathways | WP75 | Toll-like Receptor Signaling Pathway |
| netpath | Pathway_BCR | BCR |
| pid | il12_2pathway | IL12-mediated signaling events |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04623 | Cytosolic DNA-sensing pathway - Homo sapiens (human) |
| kegg | hsa05132 | Salmonella infection - Homo sapiens (human) |
| biocarta | barrestinpathway | -arrestins in gpcr desensitization |
| biocarta | barrestinsrcpathway | roles of arrestin dependent recruitment of src kinases in gpcr signaling |
| biocarta | barrmapkpathway | role of -arrestins in the activation and targeting of map kinases |
| biocarta | ccr5pathway | pertussis toxin-insensitive ccr5 signaling in macrophage |
| biocarta | cftrpathway | cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway |
| biocarta | chrebppathway | chrebp regulation by carbohydrates and camp |
| biocarta | cskpathway | activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor |
| biocarta | gcrpathway | corticosteroids and cardioprotection |
| biocarta | gspathway | activation of camp-dependent protein kinase pka |
| biocarta | pkcpathway | activation of pkc through g-protein coupled receptors |
| biocarta | raccpathway | ion channels and their functional role in vascular endothelium |
| biocarta | tubbypathway | g-protein signaling through tubby proteins |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-6783783 | Interleukin-10 signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD154 | NSC23766 | 6 |
| iGMDRD435 | BI-2536 | 4 |
| iGMDRD375 | GW-405833 | 5 |
| iGMDRD177 | Teniposide | 1 |
| iGMDRD219 | Bax channel blocker | 2 |
| iGMDRD314 | Tanespimycin | 2 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD116 | CD437 | 1 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD552 | AZD-1775 | 4 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD294 | Batimastat | 3 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 2 |
| iGMDRD434 | BMS-536924 | 5 |
| iGMDRD171 | Pemetrexed | 1 |
| iGMDRD802 | 4-methylfasudil | 2 |
| iGMDRD158 | NSC141540 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CCL4
CLASSFICATION
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