HSP90B1
Summary: This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| heat shock protein 90 beta family member 1 | MIM:191175 | Ensembl:ENSG00000166598 | HGNC:HGNC:12028 | PA36705 | 12q23.3 |
GO terms in HSP90B1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0003723 | RNA binding |
| MF | TAS | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0019903 | protein phosphatase binding |
| MF | IDA | GO:0050750 | low-density lipoprotein particle receptor binding |
| MF | IEA | GO:0051082 | unfolded protein binding |
| CC | TAS | GO:0005576 | extracellular region |
| CC | HDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | TAS | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005788 | endoplasmic reticulum lumen |
| CC | TAS | GO:0005788 | endoplasmic reticulum lumen |
| CC | IDA | GO:0005789 | endoplasmic reticulum membrane |
| CC | IDA | GO:0005829 | cytosol |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0030496 | midbody |
| CC | HDA | GO:0031012 | extracellular matrix |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IEA | GO:0034663 | endoplasmic reticulum chaperone complex |
| CC | IEA | GO:0042470 | melanosome |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | TAS | GO:0071682 | endocytic vesicle lumen |
| BP | IDA | GO:0001666 | response to hypoxia |
| BP | TAS | GO:0002224 | toll-like receptor signaling pathway |
| BP | TAS | GO:0006898 | receptor-mediated endocytosis |
| BP | NAS | GO:0015031 | protein transport |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IMP | GO:0030433 | ubiquitin-dependent ERAD pathway |
| BP | IMP | GO:0030970 | retrograde protein transport, ER to cytosol |
| BP | IDA | GO:0031247 | actin rod assembly |
| BP | TAS | GO:0034975 | protein folding in endoplasmic reticulum |
| BP | TAS | GO:0034976 | response to endoplasmic reticulum stress |
| BP | TAS | GO:0036500 | ATF6-mediated unfolded protein response |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | TAS | GO:0043066 | negative regulation of apoptotic process |
| BP | IDA | GO:0043666 | regulation of phosphoprotein phosphatase activity |
| BP | TAS | GO:0043687 | post-translational protein modification |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
| BP | NAS | GO:0051208 | sequestering of calcium ion |
| BP | IDA | GO:0071318 | cellular response to ATP |
Gene expression in normal tissue: HSP90B1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HSP90B1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2655 | ATF6 (ATF6-alpha) activates chaperone genes |
| wikipathways | WP3613 | Photodynamic therapy-induced unfolded protein response |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP3995 | Prion disease pathway |
| wikipathways | WP4066 | Interleukin-4 and 13 signaling |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| pid | il6_7pathway | IL6-mediated signaling events |
| kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| kegg | hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| kegg | hsa04918 | Thyroid hormone synthesis - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1679131 | Trafficking and processing of endosomal TLR |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors |
| reactome | R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors |
| reactome | R-HSA-3000480 | Scavenging by Class A Receptors |
| reactome | R-HSA-3000480 | Scavenging by Class A Receptors |
| reactome | R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones |
| reactome | R-HSA-381119 | Unfolded Protein Response (UPR) |
| reactome | R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes |
| reactome | R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| reactome | R-HSA-8957275 | Post-translational protein phosphorylation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD150 | RITA | 2 |
| iGMDRD701 | NVP-AUY922 | 2 |
| iGMDRD583 | LDN 193189 | 1 |
| iGMDRD307 | Manumycin A | 2 |
| iGMDRD48 | Dexamethasone | 2 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD584 | VER 155008 | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD154 | NSC23766 | 2 |
| iGMDRD945 | ML214 | 6 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD202 | Curcumin | 4 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD286 | Nsc 632839 | 1 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD889 | Compound 7d-cis | 1 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD193 | Fqi1 | 4 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 2 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD802 | 4-methylfasudil | 4 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD451 | Serdemetan | 5 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD74 | Idarubicin | 5 |
| iGMDRD730 | Kahalalide F | 3 |
| iGMDRD100 | Zebularine | 5 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD562 | Navitoclax | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HSP90B1
CLASSFICATION
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