HSP90B1

Summary: This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameheat shock protein 90 beta family member 1
OMIM IDMIM:191175
Ensembl IDEnsembl:ENSG00000166598
HGNC IDHGNC:HGNC:12028
PHARMGKB IDPA36705
Map Location12q23.3

GO terms in HSP90B1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0003723 RNA binding
MF TAS GO:0005509 calcium ion binding
MF IPI GO:0005515 protein binding
MF IEA GO:0005524 ATP binding
MF IDA GO:0019903 protein phosphatase binding
MF IDA GO:0050750 low-density lipoprotein particle receptor binding
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Gene expression in normal tissue: HSP90B1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined43Protein stability and degradation2IGFR signaling1ERK MAPK signaling1p53 pathway1Apoptosis regulation1Mitosis1Biosynthesis of secondary metabolites1Stilbenoid, diarylheptanoid and gingerol biosynthesis1Neuroactive ligand-receptor interaction1

Pathways in HSP90B1


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Database
Pathway ID
Pathway Des.
wikipathways WP2655 ATF6 (ATF6-alpha) activates chaperone genes
wikipathways WP3613 Photodynamic therapy-induced unfolded protein response
wikipathways WP3932 Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathways WP3995 Prion disease pathway
wikipathways WP4066 Interleukin-4 and 13 signaling
wikipathways WP4172 PI3K-Akt Signaling Pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD424 Tamatinib 1
iGMDRD150 RITA 2
iGMDRD701 NVP-AUY922 2
iGMDRD583 LDN 193189 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HSP90B1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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