PIP5K1B
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| phosphatidylinositol-4-phosphate 5-kinase type 1 beta | MIM:602745 | Ensembl:ENSG00000107242 | HGNC:HGNC:8995 | PA33328 | 9q21.11 |
Gene Categories:
KINASEGO terms in PIP5K1B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0000285 | 1-phosphatidylinositol-3-phosphate 5-kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | NAS | GO:0016308 | 1-phosphatidylinositol-4-phosphate 5-kinase activity |
| MF | TAS | GO:0016308 | 1-phosphatidylinositol-4-phosphate 5-kinase activity |
| MF | TAS | GO:0052810 | 1-phosphatidylinositol-5-kinase activity |
| MF | TAS | GO:0052811 | 1-phosphatidylinositol-3-phosphate 4-kinase activity |
| MF | TAS | GO:0052812 | phosphatidylinositol-3,4-bisphosphate 5-kinase activity |
| CC | IDA | GO:0001931 | uropod |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0012505 | endomembrane system |
| CC | IEA | GO:0016020 | membrane |
| BP | TAS | GO:0006661 | phosphatidylinositol biosynthetic process |
| BP | TAS | GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling |
| BP | IEA | GO:0046854 | phosphatidylinositol phosphorylation |
Gene expression in normal tissue: PIP5K1B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PIP5K1B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | plexind1_pathway | Plexin-D1 Signaling |
| pid | rac1_pathway | RAC1 signaling pathway |
| pid | rhoa_pathway | RhoA signaling pathway |
| pid | wnt_canonical_pathway | Canonical Wnt signaling pathway |
| netpath | Pathway_BCR | BCR |
| humancyc | PWY-6351 | D-myo-inositol (1,4,5)-trisphosphate biosynthesis |
| humancyc | PWY-6352 | 3-phosphoinositide biosynthesis |
| humancyc | PWY-6371 | superpathway of inositol phosphate compounds |
| kegg | hsa00562 | Inositol phosphate metabolism - Homo sapiens (human) |
| kegg | hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| kegg | hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP363 | Wnt Signaling Pathway |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1483255 | PI Metabolism |
| reactome | R-HSA-1483257 | Phospholipid metabolism |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1660499 | Synthesis of PIPs at the plasma membrane |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-201688 | WNT mediated activation of DVL |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| biocarta | rhopathway | rho cell motility signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 10 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD466 | Chaetocin | 4 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD52 | Rotenone | 1 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD74 | Idarubicin | 6 |
| iGMDRD506 | Fedratinib | 6 |
| iGMDRD577 | BIX01294 | 5 |
| iGMDRD562 | Navitoclax | 4 |
| iGMDRD60 | Quinoclamine | 4 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD330 | BRD4132 | 1 |
| iGMDRD532 | Olaparib | 2 |
| iGMDRD901 | ELCPK | 1 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD105 | Triptolide | 4 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD415 | LE-135 | 2 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD366 | PI-103 | 1 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD246 | NPC26 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PIP5K1B
CLASSFICATION
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