SIRT1
Summary: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| sirtuin 1 | MIM:604479 | Ensembl:ENSG00000096717 | HGNC:HGNC:14929 | PA37935 | 10q21.3 |
GO terms in SIRT1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005635 | nuclear envelope |
| CC | IDA | GO:0005637 | nuclear inner membrane |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005677 | chromatin silencing complex |
| CC | IDA | GO:0005719 | nuclear euchromatin |
| CC | IDA | GO:0005720 | nuclear heterochromatin |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0016605 | PML body |
| CC | IDA | GO:0033553 | rDNA heterochromatin |
| CC | IDA | GO:0035098 | ESC/E(Z) complex |
| BP | IMP | GO:0000012 | single strand break repair |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0000183 | chromatin silencing at rDNA |
| BP | TAS | GO:0000183 | chromatin silencing at rDNA |
| BP | IMP | GO:0000720 | pyrimidine dimer repair by nucleotide-excision repair |
| BP | ISS | GO:0000731 | DNA synthesis involved in DNA repair |
| BP | IDA | GO:0001525 | angiogenesis |
| BP | IEA | GO:0001542 | ovulation from ovarian follicle |
| BP | ISS | GO:0001678 | cellular glucose homeostasis |
| BP | ISS | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IMP | GO:0001938 | positive regulation of endothelial cell proliferation |
| BP | IDA | GO:0002821 | positive regulation of adaptive immune response |
| BP | IMP | GO:0006325 | chromatin organization |
| BP | TAS | GO:0006342 | chromatin silencing |
| BP | IDA | GO:0006343 | establishment of chromatin silencing |
| BP | IMP | GO:0006344 | maintenance of chromatin silencing |
| BP | TAS | GO:0006346 | methylation-dependent chromatin silencing |
| BP | IEA | GO:0006364 | rRNA processing |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0006471 | protein ADP-ribosylation |
| BP | IDA | GO:0006476 | protein deacetylation |
| BP | IMP | GO:0006476 | protein deacetylation |
| BP | TAS | GO:0006476 | protein deacetylation |
| BP | ISS | GO:0006642 | triglyceride mobilization |
| BP | IDA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IDA | GO:0006979 | response to oxidative stress |
| BP | IDA | GO:0007179 | transforming growth factor beta receptor signaling pathway |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | IDA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IEA | GO:0007517 | muscle organ development |
| BP | TAS | GO:0007569 | cell aging |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | ISS | GO:0009267 | cellular response to starvation |
| BP | IMP | GO:0010629 | negative regulation of gene expression |
| BP | ISS | GO:0010875 | positive regulation of cholesterol efflux |
| BP | ISS | GO:0010883 | regulation of lipid storage |
| BP | ISS | GO:0010906 | regulation of glucose metabolic process |
| BP | ISS | GO:0010934 | macrophage cytokine production |
| BP | ISS | GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling |
| BP | IEA | GO:0016032 | viral process |
| BP | IDA | GO:0016239 | positive regulation of macroautophagy |
| BP | IDA | GO:0016567 | protein ubiquitination |
| BP | IMP | GO:0016567 | protein ubiquitination |
| BP | IDA | GO:0016575 | histone deacetylation |
| BP | IMP | GO:0018394 | peptidyl-lysine acetylation |
| BP | ISS | GO:0030225 | macrophage differentiation |
| BP | IMP | GO:0030308 | negative regulation of cell growth |
| BP | ISS | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| BP | ISS | GO:0031393 | negative regulation of prostaglandin biosynthetic process |
| BP | IDA | GO:0031648 | protein destabilization |
| BP | ISS | GO:0031648 | protein destabilization |
| BP | IMP | GO:0031937 | positive regulation of chromatin silencing |
| BP | IMP | GO:0032007 | negative regulation of TOR signaling |
| BP | IMP | GO:0032071 | regulation of endodeoxyribonuclease activity |
| BP | IDA | GO:0032088 | negative regulation of NF-kappaB transcription factor activity |
| BP | ISS | GO:0032868 | response to insulin |
| BP | IMP | GO:0032922 | circadian regulation of gene expression |
| BP | ISS | GO:0032922 | circadian regulation of gene expression |
| BP | IMP | GO:0033158 | regulation of protein import into nucleus, translocation |
| BP | ISS | GO:0033210 | leptin-mediated signaling pathway |
| BP | ISS | GO:0034391 | regulation of smooth muscle cell apoptotic process |
| BP | IDA | GO:0034983 | peptidyl-lysine deacetylation |
| BP | ISS | GO:0035356 | cellular triglyceride homeostasis |
| BP | ISS | GO:0035358 | regulation of peroxisome proliferator activated receptor signaling pathway |
| BP | IMP | GO:0042127 | regulation of cell proliferation |
| BP | IMP | GO:0042326 | negative regulation of phosphorylation |
| BP | IDA | GO:0042542 | response to hydrogen peroxide |
| BP | IEA | GO:0042595 | behavioral response to starvation |
| BP | ISS | GO:0042632 | cholesterol homeostasis |
| BP | IMP | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| BP | IMP | GO:0042981 | regulation of apoptotic process |
| BP | IDA | GO:0043065 | positive regulation of apoptotic process |
| BP | IMP | GO:0043065 | positive regulation of apoptotic process |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | IDA | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IMP | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| BP | IMP | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IDA | GO:0043433 | negative regulation of DNA-binding transcription factor activity |
| BP | IMP | GO:0043433 | negative regulation of DNA-binding transcription factor activity |
| BP | IDA | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator |
| BP | IDA | GO:0043536 | positive regulation of blood vessel endothelial cell migration |
| BP | ISS | GO:0044321 | response to leptin |
| BP | IDA | GO:0045348 | positive regulation of MHC class II biosynthetic process |
| BP | ISS | GO:0045599 | negative regulation of fat cell differentiation |
| BP | IMP | GO:0045739 | positive regulation of DNA repair |
| BP | IDA | GO:0045766 | positive regulation of angiogenesis |
| BP | IMP | GO:0045766 | positive regulation of angiogenesis |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0046628 | positive regulation of insulin receptor signaling pathway |
| BP | ISS | GO:0050872 | white fat cell differentiation |
| BP | IDA | GO:0051097 | negative regulation of helicase activity |
| BP | IEA | GO:0051152 | positive regulation of smooth muscle cell differentiation |
| BP | IMP | GO:0051574 | positive regulation of histone H3-K9 methylation |
| BP | IMP | GO:0051898 | negative regulation of protein kinase B signaling |
| BP | ISS | GO:0055089 | fatty acid homeostasis |
| BP | IMP | GO:0060766 | negative regulation of androgen receptor signaling pathway |
| BP | IEA | GO:0061647 | histone H3-K9 modification |
| BP | IDA | GO:0070301 | cellular response to hydrogen peroxide |
| BP | ISS | GO:0070857 | regulation of bile acid biosynthetic process |
| BP | IMP | GO:0070914 | UV-damage excision repair |
| BP | IDA | GO:0070932 | histone H3 deacetylation |
| BP | IMP | GO:0070932 | histone H3 deacetylation |
| BP | IDA | GO:0071356 | cellular response to tumor necrosis factor |
| BP | IMP | GO:0071441 | negative regulation of histone H3-K14 acetylation |
| BP | IMP | GO:0071456 | cellular response to hypoxia |
| BP | ISS | GO:0071479 | cellular response to ionizing radiation |
| BP | IMP | GO:0071900 | regulation of protein serine/threonine kinase activity |
| BP | ISS | GO:0090335 | regulation of brown fat cell differentiation |
| BP | IMP | GO:0090400 | stress-induced premature senescence |
| BP | TAS | GO:1900034 | regulation of cellular response to heat |
| BP | IEA | GO:1900113 | negative regulation of histone H3-K9 trimethylation |
| BP | IEA | GO:1901215 | negative regulation of neuron death |
| BP | IMP | GO:1901984 | negative regulation of protein acetylation |
| BP | ISS | GO:1902166 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| BP | IMP | GO:1902176 | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
| BP | IEA | GO:1902237 | positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
| BP | ISS | GO:1904179 | positive regulation of adipose tissue development |
| BP | IEA | GO:1990619 | histone H3-K9 deacetylation |
| BP | IEA | GO:1990830 | cellular response to leukemia inhibitory factor |
| BP | ISS | GO:2000111 | positive regulation of macrophage apoptotic process |
| BP | IDA | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity |
| BP | IMP | GO:2000481 | positive regulation of cAMP-dependent protein kinase activity |
| BP | IMP | GO:2000619 | negative regulation of histone H4-K16 acetylation |
| BP | IMP | GO:2000655 | negative regulation of cellular response to testosterone stimulus |
| BP | IDA | GO:2000757 | negative regulation of peptidyl-lysine acetylation |
| BP | IDA | GO:2000773 | negative regulation of cellular senescence |
| BP | IMP | GO:2000773 | negative regulation of cellular senescence |
| BP | IDA | GO:2000774 | positive regulation of cellular senescence |
| MF | IEA | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding |
| MF | IEA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IPI | GO:0002039 | p53 binding |
| MF | IDA | GO:0003714 | transcription corepressor activity |
| MF | ISS | GO:0003714 | transcription corepressor activity |
| MF | TAS | GO:0003950 | NAD+ ADP-ribosyltransferase activity |
| MF | EXP | GO:0004407 | histone deacetylase activity |
| MF | IDA | GO:0004407 | histone deacetylase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008022 | protein C-terminus binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IDA | GO:0017136 | NAD-dependent histone deacetylase activity |
| MF | IDA | GO:0019213 | deacetylase activity |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IDA | GO:0033558 | protein deacetylase activity |
| MF | IMP | GO:0033558 | protein deacetylase activity |
| MF | IDA | GO:0034979 | NAD-dependent protein deacetylase activity |
| MF | IMP | GO:0034979 | NAD-dependent protein deacetylase activity |
| MF | TAS | GO:0034979 | NAD-dependent protein deacetylase activity |
| MF | IPI | GO:0035257 | nuclear hormone receptor binding |
| MF | IPI | GO:0042393 | histone binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IPI | GO:0043398 | HLH domain binding |
| MF | IPI | GO:0043425 | bHLH transcription factor binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | ISS | GO:0046969 | NAD-dependent histone deacetylase activity (H3-K9 specific) |
| MF | IPI | GO:0051019 | mitogen-activated protein kinase binding |
| MF | IEA | GO:0070403 | NAD+ binding |
| MF | IPI | GO:1990254 | keratin filament binding |
Gene expression in normal tissue: SIRT1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SIRT1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | ar_tf_pathway | Regulation of Androgen receptor activity |
| pid | e2f_pathway | E2F transcription factor network |
| pid | foxopathway | FoxO family signaling |
| pid | hdac_classiii_pathway | Signaling events mediated by HDAC Class III |
| pid | hif2pathway | HIF-2-alpha transcription factor network |
| pid | p73pathway | p73 transcription factor network |
| pid | rb_1pathway | Regulation of retinoblastoma protein |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04211 | Longevity regulating pathway - Homo sapiens (human) |
| kegg | hsa04213 | Longevity regulating pathway - multiple species - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
| kegg | hsa05031 | Amphetamine addiction - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| pharmgkb | PA165948566 | Metformin Pathway, Pharmacodynamic |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| wikipathways | WP138 | Androgen receptor signaling pathway |
| wikipathways | WP1541 | Energy Metabolism |
| wikipathways | WP1982 | Sterol Regulatory Element-Binding Proteins (SREBP) signalling |
| wikipathways | WP2011 | SREBF and miR33 in cholesterol and lipid homeostasis |
| wikipathways | WP3298 | Melatonin metabolism and effects |
| wikipathways | WP3630 | NAD metabolism, sirtuins and aging |
| wikipathways | WP3644 | NAD+ metabolism |
| wikipathways | WP3645 | NAD+ biosynthetic pathways |
| wikipathways | WP3670 | Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway |
| wikipathways | WP4186 | Somatroph axis (GH) and its relationship to dietary restriction and aging |
| wikipathways | WP4191 | Caloric restriction and aging |
| reactome | R-HSA-212165 | Epigenetic regulation of gene expression |
| reactome | R-HSA-212165 | Epigenetic regulation of gene expression |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-3371453 | Regulation of HSF1-mediated heat shock response |
| reactome | R-HSA-3371556 | Cellular response to heat stress |
| reactome | R-HSA-400253 | Circadian Clock |
| reactome | R-HSA-427359 | SIRT1 negatively regulates rRNA expression |
| reactome | R-HSA-427359 | SIRT1 negatively regulates rRNA expression |
| reactome | R-HSA-5250941 | Negative epigenetic regulation of rRNA expression |
| reactome | R-HSA-5250941 | Negative epigenetic regulation of rRNA expression |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| biocarta | pmlpathway | regulation of transcriptional activity by pml |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD1 | Nicotin-Amide | 1 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD387 | CHIR-99021 | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD434 | BMS-536924 | 6 |
| iGMDRD255 | SB225002 | 4 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD524 | ISX-9 | 1 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD329 | Merck60 | 5 |
| iGMDRD577 | BIX01294 | 7 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD366 | PI-103 | 2 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD286 | Nsc 632839 | 1 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD872 | BRD7137 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SIRT1
CLASSFICATION
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