SIRT1
Summary: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Namesirtuin 1 OMIM IDMIM:604479 Ensembl IDEnsembl:ENSG00000096717 HGNC IDHGNC:HGNC:14929 PHARMGKB IDPA37935 Map Location10q21.3 | |||||
GO terms in SIRT1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005635 | nuclear envelope |
| CC | IDA | GO:0005637 | nuclear inner membrane |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
Gene expression in normal tissue: SIRT1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SIRT1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | ar_tf_pathway | Regulation of Androgen receptor activity |
| pid | e2f_pathway | E2F transcription factor network |
| pid | foxopathway | FoxO family signaling |
| pid | hdac_classiii_pathway | Signaling events mediated by HDAC Class III |
| pid | hif2pathway | HIF-2-alpha transcription factor network |
| pid | p73pathway | p73 transcription factor network |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SIRT1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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