SIRT1


Summary: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
sirtuin 1MIM:604479Ensembl:ENSG00000096717HGNC:HGNC:14929PA3793510q21.3

GO terms in SIRT1


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0000790nuclear chromatin
CCIDAGO:0005634nucleus
CCIDAGO:0005635nuclear envelope
CCIDAGO:0005637nuclear inner membrane
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005677chromatin silencing complex
CCIDAGO:0005719nuclear euchromatin
CCIDAGO:0005720nuclear heterochromatin
CCIDAGO:0005730nucleolus
CCIDAGO:0005730nucleolus
CCIDAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCIDAGO:0005739mitochondrion
CCIDAGO:0005829cytosol
CCIDAGO:0016605PML body
CCIDAGO:0033553rDNA heterochromatin
CCIDAGO:0035098ESC/E(Z) complex
BPIMPGO:0000012single strand break repair
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPIMPGO:0000122negative regulation of transcription by RNA polymerase II
BPIDAGO:0000183chromatin silencing at rDNA
BPTASGO:0000183chromatin silencing at rDNA
BPIMPGO:0000720pyrimidine dimer repair by nucleotide-excision repair
BPISSGO:0000731DNA synthesis involved in DNA repair
BPIDAGO:0001525angiogenesis
BPIEAGO:0001542ovulation from ovarian follicle
BPISSGO:0001678cellular glucose homeostasis
BPISSGO:0001934positive regulation of protein phosphorylation
BPIMPGO:0001938positive regulation of endothelial cell proliferation
BPIDAGO:0002821positive regulation of adaptive immune response
BPIMPGO:0006325chromatin organization
BPTASGO:0006342chromatin silencing
BPIDAGO:0006343establishment of chromatin silencing
BPIMPGO:0006344maintenance of chromatin silencing
BPTASGO:0006346methylation-dependent chromatin silencing
BPIEAGO:0006364rRNA processing
BPIEAGO:0006366transcription by RNA polymerase II
BPTASGO:0006471protein ADP-ribosylation
BPIDAGO:0006476protein deacetylation
BPIMPGO:0006476protein deacetylation
BPTASGO:0006476protein deacetylation
BPISSGO:0006642triglyceride mobilization
BPIDAGO:0006974cellular response to DNA damage stimulus
BPIDAGO:0006979response to oxidative stress
BPIDAGO:0007179transforming growth factor beta receptor signaling pathway
BPIEAGO:0007283spermatogenesis
BPIDAGO:0007346regulation of mitotic cell cycle
BPIEAGO:0007517muscle organ development
BPTASGO:0007569cell aging
BPIMPGO:0008284positive regulation of cell proliferation
BPISSGO:0009267cellular response to starvation
BPIMPGO:0010629negative regulation of gene expression
BPISSGO:0010875positive regulation of cholesterol efflux
BPISSGO:0010883regulation of lipid storage
BPISSGO:0010906regulation of glucose metabolic process
BPISSGO:0010934macrophage cytokine production
BPISSGO:0014068positive regulation of phosphatidylinositol 3-kinase signaling
BPIEAGO:0016032viral process
BPIDAGO:0016239positive regulation of macroautophagy
BPIDAGO:0016567protein ubiquitination
BPIMPGO:0016567protein ubiquitination
BPIDAGO:0016575histone deacetylation
BPIMPGO:0018394peptidyl-lysine acetylation
BPISSGO:0030225macrophage differentiation
BPIMPGO:0030308negative regulation of cell growth
BPISSGO:0030512negative regulation of transforming growth factor beta receptor signaling pathway
BPISSGO:0031393negative regulation of prostaglandin biosynthetic process
BPIDAGO:0031648protein destabilization
BPISSGO:0031648protein destabilization
BPIMPGO:0031937positive regulation of chromatin silencing
BPIMPGO:0032007negative regulation of TOR signaling
BPIMPGO:0032071regulation of endodeoxyribonuclease activity
BPIDAGO:0032088negative regulation of NF-kappaB transcription factor activity
BPISSGO:0032868response to insulin
BPIMPGO:0032922circadian regulation of gene expression
BPISSGO:0032922circadian regulation of gene expression
BPIMPGO:0033158regulation of protein import into nucleus, translocation
BPISSGO:0033210leptin-mediated signaling pathway
BPISSGO:0034391regulation of smooth muscle cell apoptotic process
BPIDAGO:0034983peptidyl-lysine deacetylation
BPISSGO:0035356cellular triglyceride homeostasis
BPISSGO:0035358regulation of peroxisome proliferator activated receptor signaling pathway
BPIMPGO:0042127regulation of cell proliferation
BPIMPGO:0042326negative regulation of phosphorylation
BPIDAGO:0042542response to hydrogen peroxide
BPIEAGO:0042595behavioral response to starvation
BPISSGO:0042632cholesterol homeostasis
BPIMPGO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
BPIMPGO:0042981regulation of apoptotic process
BPIDAGO:0043065positive regulation of apoptotic process
BPIMPGO:0043065positive regulation of apoptotic process
BPIMPGO:0043066negative regulation of apoptotic process
BPIDAGO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling
BPIMPGO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process
BPIMPGO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
BPIDAGO:0043433negative regulation of DNA-binding transcription factor activity
BPIMPGO:0043433negative regulation of DNA-binding transcription factor activity
BPIDAGO:0043518negative regulation of DNA damage response, signal transduction by p53 class mediator
BPIDAGO:0043536positive regulation of blood vessel endothelial cell migration
BPISSGO:0044321response to leptin
BPIDAGO:0045348positive regulation of MHC class II biosynthetic process
BPISSGO:0045599negative regulation of fat cell differentiation
BPIMPGO:0045739positive regulation of DNA repair
BPIDAGO:0045766positive regulation of angiogenesis
BPIMPGO:0045766positive regulation of angiogenesis
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0046628positive regulation of insulin receptor signaling pathway
BPISSGO:0050872white fat cell differentiation
BPIDAGO:0051097negative regulation of helicase activity
BPIEAGO:0051152positive regulation of smooth muscle cell differentiation
BPIMPGO:0051574positive regulation of histone H3-K9 methylation
BPIMPGO:0051898negative regulation of protein kinase B signaling
BPISSGO:0055089fatty acid homeostasis
BPIMPGO:0060766negative regulation of androgen receptor signaling pathway
BPIEAGO:0061647histone H3-K9 modification
BPIDAGO:0070301cellular response to hydrogen peroxide
BPISSGO:0070857regulation of bile acid biosynthetic process
BPIMPGO:0070914UV-damage excision repair
BPIDAGO:0070932histone H3 deacetylation
BPIMPGO:0070932histone H3 deacetylation
BPIDAGO:0071356cellular response to tumor necrosis factor
BPIMPGO:0071441negative regulation of histone H3-K14 acetylation
BPIMPGO:0071456cellular response to hypoxia
BPISSGO:0071479cellular response to ionizing radiation
BPIMPGO:0071900regulation of protein serine/threonine kinase activity
BPISSGO:0090335regulation of brown fat cell differentiation
BPIMPGO:0090400stress-induced premature senescence
BPTASGO:1900034regulation of cellular response to heat
BPIEAGO:1900113negative regulation of histone H3-K9 trimethylation
BPIEAGO:1901215negative regulation of neuron death
BPIMPGO:1901984negative regulation of protein acetylation
BPISSGO:1902166negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
BPIMPGO:1902176negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
BPIEAGO:1902237positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
BPISSGO:1904179positive regulation of adipose tissue development
BPIEAGO:1990619histone H3-K9 deacetylation
BPIEAGO:1990830cellular response to leukemia inhibitory factor
BPISSGO:2000111positive regulation of macrophage apoptotic process
BPIDAGO:2000480negative regulation of cAMP-dependent protein kinase activity
BPIMPGO:2000481positive regulation of cAMP-dependent protein kinase activity
BPIMPGO:2000619negative regulation of histone H4-K16 acetylation
BPIMPGO:2000655negative regulation of cellular response to testosterone stimulus
BPIDAGO:2000757negative regulation of peptidyl-lysine acetylation
BPIDAGO:2000773negative regulation of cellular senescence
BPIMPGO:2000773negative regulation of cellular senescence
BPIDAGO:2000774positive regulation of cellular senescence
MFIEAGO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding
MFIEAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIPIGO:0002039p53 binding
MFIDAGO:0003714transcription corepressor activity
MFISSGO:0003714transcription corepressor activity
MFTASGO:0003950NAD+ ADP-ribosyltransferase activity
MFEXPGO:0004407histone deacetylase activity
MFIDAGO:0004407histone deacetylase activity
MFIPIGO:0005515protein binding
MFIPIGO:0008022protein C-terminus binding
MFIPIGO:0008134transcription factor binding
MFIDAGO:0017136NAD-dependent histone deacetylase activity
MFIDAGO:0019213deacetylase activity
MFIPIGO:0019899enzyme binding
MFIDAGO:0033558protein deacetylase activity
MFIMPGO:0033558protein deacetylase activity
MFIDAGO:0034979NAD-dependent protein deacetylase activity
MFIMPGO:0034979NAD-dependent protein deacetylase activity
MFTASGO:0034979NAD-dependent protein deacetylase activity
MFIPIGO:0035257nuclear hormone receptor binding
MFIPIGO:0042393histone binding
MFIPIGO:0042802identical protein binding
MFIPIGO:0043398HLH domain binding
MFIPIGO:0043425bHLH transcription factor binding
MFIEAGO:0046872metal ion binding
MFISSGO:0046969NAD-dependent histone deacetylase activity (H3-K9 specific)
MFIPIGO:0051019mitogen-activated protein kinase binding
MFIEAGO:0070403NAD+ binding
MFIPIGO:1990254keratin filament binding

Gene expression in normal tissue: SIRT1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SIRT1


DatabasePathway IDPathway Des.
pidar_tf_pathwayRegulation of Androgen receptor activity
pide2f_pathwayE2F transcription factor network
pidfoxopathwayFoxO family signaling
pidhdac_classiii_pathwaySignaling events mediated by HDAC Class III
pidhif2pathwayHIF-2-alpha transcription factor network
pidp73pathwayp73 transcription factor network
pidrb_1pathwayRegulation of retinoblastoma protein
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04152AMPK signaling pathway - Homo sapiens (human)
kegghsa04211Longevity regulating pathway - Homo sapiens (human)
kegghsa04213Longevity regulating pathway - multiple species - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04922Glucagon signaling pathway - Homo sapiens (human)
kegghsa05031Amphetamine addiction - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
pharmgkbPA165948566Metformin Pathway, Pharmacodynamic
netpathPathway_AndrogenReceptorAndrogenReceptor
wikipathwaysWP138Androgen receptor signaling pathway
wikipathwaysWP1541Energy Metabolism
wikipathwaysWP1982Sterol Regulatory Element-Binding Proteins (SREBP) signalling
wikipathwaysWP2011SREBF and miR33 in cholesterol and lipid homeostasis
wikipathwaysWP3298Melatonin metabolism and effects
wikipathwaysWP3630NAD metabolism, sirtuins and aging
wikipathwaysWP3644NAD+ metabolism
wikipathwaysWP3645NAD+ biosynthetic pathways
wikipathwaysWP3670Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway
wikipathwaysWP4186Somatroph axis (GH) and its relationship to dietary restriction and aging
wikipathwaysWP4191Caloric restriction and aging
reactomeR-HSA-212165Epigenetic regulation of gene expression
reactomeR-HSA-212165Epigenetic regulation of gene expression
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-3371453Regulation of HSF1-mediated heat shock response
reactomeR-HSA-3371556Cellular response to heat stress
reactomeR-HSA-400253Circadian Clock
reactomeR-HSA-427359SIRT1 negatively regulates rRNA expression
reactomeR-HSA-427359SIRT1 negatively regulates rRNA expression
reactomeR-HSA-5250941Negative epigenetic regulation of rRNA expression
reactomeR-HSA-5250941Negative epigenetic regulation of rRNA expression
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8953897Cellular responses to external stimuli
biocartapmlpathwayregulation of transcriptional activity by pml

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD494Neopeltolide3
iGMDRD781Sirolimus3
iGMDRD560MK-22063
iGMDRD546BMS-7548073
iGMDRD1Nicotin-Amide1
iGMDRD424Tamatinib3
iGMDRD387CHIR-990213
iGMDRD772BRD47703
iGMDRD330BRD41323
iGMDRD679Bistramide A2
iGMDRD434BMS-5369246
iGMDRD255SB2250024
iGMDRD353PD03259011
iGMDRD23Gossypol1
iGMDRD524ISX-91
iGMDRD60Quinoclamine2
iGMDRD246NPC263
iGMDRD506Fedratinib2
iGMDRD888Compound 441
iGMDRD329Merck605
iGMDRD577BIX012947
iGMDRD562Navitoclax6
iGMDRD366PI-1032
iGMDRD188Piperlongumine5
iGMDRD871BRD63683
iGMDRD286Nsc 6328391
iGMDRD74Idarubicin3
iGMDRD399Selumetinib3
iGMDRD872BRD71372

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SIRT1

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