RANBP17
Summary: The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:606141 Ensembl IDEnsembl:ENSG00000204764 HGNC IDHGNC:HGNC:14428 PHARMGKB IDPA34208 Map Location5q35.1 | |||||
Gene Categories:
TRANSPORTERGO terms in RANBP17
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005049 | nuclear export signal receptor activity |
| MF | NAS | GO:0005525 | GTP binding |
| BP | NAS | GO:0006606 | protein import into nucleus |
| BP | IBA | GO:0006611 | protein export from nucleus |
| BP | IEA | GO:0051028 | mRNA transport |
| CC | IBA | GO:0005643 | nuclear pore |
Gene expression in normal tissue: RANBP17
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RANBP17
Database | Pathway ID | Pathway Des. |
|---|---|---|
| No matching records found | ||
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RANBP17
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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