RANBP17
Summary: The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| RAN binding protein 17 | MIM:606141 | Ensembl:ENSG00000204764 | HGNC:HGNC:14428 | PA34208 | 5q35.1 |
Gene Categories:
TRANSPORTERGO terms in RANBP17
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005049 | nuclear export signal receptor activity |
| MF | NAS | GO:0005525 | GTP binding |
| BP | NAS | GO:0006606 | protein import into nucleus |
| BP | IBA | GO:0006611 | protein export from nucleus |
| BP | IEA | GO:0051028 | mRNA transport |
| CC | IBA | GO:0005643 | nuclear pore |
| CC | NAS | GO:0005643 | nuclear pore |
| CC | IBA | GO:0005737 | cytoplasm |
Gene expression in normal tissue: RANBP17
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RANBP17
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD387 | CHIR-99021 | 2 |
| iGMDRD433 | Lexibulin | 2 |
| iGMDRD126 | Tipifarnib | 7 |
| iGMDRD484 | Pluripotin | 2 |
| iGMDRD483 | SCH-529074 | 1 |
| iGMDRD779 | PRL-3 Inhibitor I | 1 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD71 | Sparfosic acid | 3 |
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD280 | CYTOCHALASIN B | 6 |
| iGMDRD802 | 4-methylfasudil | 4 |
| iGMDRD255 | SB225002 | 5 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD782 | DC-45-A2 | 4 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD506 | Fedratinib | 6 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD74 | Idarubicin | 4 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD451 | Serdemetan | 5 |
| iGMDRD524 | ISX-9 | 5 |
| iGMDRD598 | QS-11 | 2 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD60 | Quinoclamine | 8 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 2 |
| iGMDRD314 | Tanespimycin | 1 |
| iGMDRD698 | Neratinib | 5 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD154 | NSC23766 | 4 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD137 | Indisulam | 5 |
| iGMDRD202 | Curcumin | 4 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD329 | Merck60 | 6 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD300 | Tozasertib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RANBP17
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