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ATP8B1

Summary: This gene encodes a member of the P-type cation transport ATPase family, which belongs to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. Mutations in this gene may result in progressive familial intrahepatic cholestasis type 1 and in benign recurrent intrahepatic cholestasis. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
ATPase phospholipid transporting 8B1	MIM:602397	Ensembl:ENSG00000081923	HGNC:HGNC:3706	PA265	18q21.31

Gene Categories:

DRUG RESISTANCE ABC TRANSPORTER TRANSPORTER

GO terms in ATP8B1

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IEA	GO:0000287	magnesium ion binding
MF	IBA	GO:0004012	phospholipid-translocating ATPase activity
MF	TAS	GO:0004012	phospholipid-translocating ATPase activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005524	ATP binding
MF	IEA	GO:0015247	aminophospholipid transmembrane transporter activity
MF	IEA	GO:1901612	cardiolipin binding
BP	IDA	GO:0006855	drug transmembrane transport
BP	IBA	GO:0007030	Golgi organization
BP	IEA	GO:0007605	sensory perception of sound
BP	IEA	GO:0008206	bile acid metabolic process
BP	NAS	GO:0015721	bile acid and bile salt transport
BP	IEA	GO:0015917	aminophospholipid transport
BP	IEA	GO:0021650	vestibulocochlear nerve formation
BP	IMP	GO:0032534	regulation of microvillus assembly
BP	TAS	GO:0034220	ion transmembrane transport
BP	IBA	GO:0045332	phospholipid translocation
BP	IDA	GO:0045332	phospholipid translocation
BP	NAS	GO:0045332	phospholipid translocation
BP	IMP	GO:0045892	negative regulation of transcription, DNA-templated
BP	IEA	GO:0060119	inner ear receptor cell development
CC	IDA	GO:0005783	endoplasmic reticulum
CC	IBA	GO:0005794	Golgi apparatus
CC	IDA	GO:0005794	Golgi apparatus
CC	IBA	GO:0005886	plasma membrane
CC	IDA	GO:0005886	plasma membrane
CC	TAS	GO:0005886	plasma membrane
CC	NAS	GO:0005887	integral component of plasma membrane
CC	IDA	GO:0016324	apical plasma membrane
CC	IEA	GO:0031526	brush border membrane
CC	IEA	GO:0032420	stereocilium

Gene expression in normal tissue: ATP8B1

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ATP8B1

Database	Pathway ID	Pathway Des.
reactome	R-HSA-382551	Transport of small molecules
reactome	R-HSA-936837	Ion transport by P-type ATPases
reactome	R-HSA-983712	Ion channel transport

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD546	BMS-754807	1
iGMDRD670	ML 210	2
iGMDRD781	Sirolimus	2
iGMDRD494	Neopeltolide	3
iGMDRD126	Tipifarnib	2
iGMDRD599	Salermide	3
iGMDRD634	SCHEMBL2608041	2
iGMDRD107	Valdecoxib	2
iGMDRD201	SKI II	2
iGMDRD71	Sparfosic acid	3
iGMDRD193	Fqi1	2
iGMDRD782	DC-45-A2	2
iGMDRD441	TW 37	1
iGMDRD318	PAC-1	3
iGMDRD226	ML006	2
iGMDRD260	FQI-2	2
iGMDRD131	Erlotinib	1
iGMDRD64	Parbendazole	3
iGMDRD268	Cerulenin	1
iGMDRD23	Gossypol	2
iGMDRD399	Selumetinib	3
iGMDRD74	Idarubicin	2
iGMDRD887	Compound 23 citrate	3
iGMDRD577	BIX01294	3
iGMDRD116	CD437	2
iGMDRD652	UNC0638	3
iGMDRD405	PIK-75	2
iGMDRD84	Lovastatin acid	1
iGMDRD248	BRD4354	1
iGMDRD512	nutlin 3	2
iGMDRD123	Isoevodiamine	4
iGMDRD211	(1S,3R)-RSL3	2
iGMDRD351	GW843682X	2
iGMDRD434	BMS-536924	3
iGMDRD481	Dactolisib	2
iGMDRD158	NSC141540	4
iGMDRD271	Brefeldin A	2
iGMDRD103	SN-38	4
iGMDRD5	Tyrphostin AG 1478	3
iGMDRD246	NPC26	2
iGMDRD300	Tozasertib	2
iGMDRD366	PI-103	2
iGMDRD329	Merck60	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ATP8B1

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.