ATP8B1

Summary: This gene encodes a member of the P-type cation transport ATPase family, which belongs to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. Mutations in this gene may result in progressive familial intrahepatic cholestasis type 1 and in benign recurrent intrahepatic cholestasis. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameATPase phospholipid transporting 8B1
OMIM IDMIM:602397
Ensembl IDEnsembl:ENSG00000081923
HGNC IDHGNC:HGNC:3706
PHARMGKB IDPA265
Map Location18q21.31

GO terms in ATP8B1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0000287 magnesium ion binding
MF IBA GO:0004012 phospholipid-translocating ATPase activity
MF TAS GO:0004012 phospholipid-translocating ATPase activity
MF IPI GO:0005515 protein binding
MF IEA GO:0005524 ATP binding
MF IEA GO:0015247 aminophospholipid transmembrane transporter activity
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Gene expression in normal tissue: ATP8B1

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 82BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 11OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 4

Gene-drug pathway distribution

undefined27PI3K/MTOR signaling2Apoptosis regulation2DNA replication2Ferroptosis1Cell cycle1Mitosis1Chromatin histone methylation1Biosynthesis of secondary metabolites1Longevity regulating pathway1

Pathways in ATP8B1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-382551 Transport of small molecules
reactome R-HSA-936837 Ion transport by P-type ATPases
reactome R-HSA-983712 Ion channel transport
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD546 BMS-754807 1
iGMDRD670 ML 210 2
iGMDRD781 Sirolimus 2
iGMDRD494 Neopeltolide 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ATP8B1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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