CREB1
Summary: This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cAMP responsive element binding protein 1 | MIM:123810 | Ensembl:ENSG00000118260 | HGNC:HGNC:2345 | PA26864 | 2q33.3 |
GO terms in CREB1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IC | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IPI | GO:0001102 | RNA polymerase II activating transcription factor binding |
| MF | IDA | GO:0001190 | transcriptional activator activity, RNA polymerase II transcription factor binding |
| MF | IEA | GO:0001225 | RNA polymerase II transcription coactivator binding |
| MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IDA | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding |
| MF | TAS | GO:0003712 | transcription coregulator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IEA | GO:0030544 | Hsp70 protein binding |
| MF | IEA | GO:0035035 | histone acetyltransferase binding |
| MF | IDA | GO:0035497 | cAMP response element binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IEA | GO:1990763 | arrestin family protein binding |
| BP | IEA | GO:0001666 | response to hypoxia |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0007179 | transforming growth factor beta receptor signaling pathway |
| BP | IEA | GO:0007409 | axonogenesis |
| BP | IEA | GO:0007568 | aging |
| BP | IEA | GO:0007595 | lactation |
| BP | IEA | GO:0007613 | memory |
| BP | ISS | GO:0007623 | circadian rhythm |
| BP | IEA | GO:0008361 | regulation of cell size |
| BP | IEA | GO:0008542 | visual learning |
| BP | IDA | GO:0010033 | response to organic substance |
| BP | IDA | GO:0010944 | negative regulation of transcription by competitive promoter binding |
| BP | IEA | GO:0014823 | response to activity |
| BP | IEA | GO:0016032 | viral process |
| BP | IEA | GO:0021983 | pituitary gland development |
| BP | IEA | GO:0032916 | positive regulation of transforming growth factor beta3 production |
| BP | IEA | GO:0033363 | secretory granule organization |
| BP | ISS | GO:0033762 | response to glucagon |
| BP | IEA | GO:0034670 | chemotaxis to arachidonic acid |
| BP | IEA | GO:0035094 | response to nicotine |
| BP | IEA | GO:0035729 | cellular response to hepatocyte growth factor stimulus |
| BP | IEA | GO:0036120 | cellular response to platelet-derived growth factor stimulus |
| BP | IEA | GO:0040018 | positive regulation of multicellular organism growth |
| BP | IEA | GO:0042752 | regulation of circadian rhythm |
| BP | IEA | GO:0043065 | positive regulation of apoptotic process |
| BP | ISS | GO:0045600 | positive regulation of fat cell differentiation |
| BP | IEA | GO:0045672 | positive regulation of osteoclast differentiation |
| BP | ISS | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IEA | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0046887 | positive regulation of hormone secretion |
| BP | ISS | GO:0046889 | positive regulation of lipid biosynthetic process |
| BP | IEA | GO:0048145 | regulation of fibroblast proliferation |
| BP | ISS | GO:0050821 | protein stabilization |
| BP | IEA | GO:0055025 | positive regulation of cardiac muscle tissue development |
| BP | IEA | GO:0060251 | regulation of glial cell proliferation |
| BP | IEA | GO:0060430 | lung saccule development |
| BP | IEA | GO:0060509 | type I pneumocyte differentiation |
| BP | IEA | GO:0071294 | cellular response to zinc ion |
| BP | IEA | GO:0071398 | cellular response to fatty acid |
| BP | IEA | GO:1900273 | positive regulation of long-term synaptic potentiation |
| BP | IEA | GO:1901215 | negative regulation of neuron death |
| BP | IEA | GO:1902065 | response to L-glutamate |
| BP | IEA | GO:1990090 | cellular response to nerve growth factor stimulus |
| BP | IEA | GO:1990314 | cellular response to insulin-like growth factor stimulus |
| BP | IEA | GO:1990830 | cellular response to leukemia inhibitory factor |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005667 | transcription factor complex |
| CC | IDA | GO:0005719 | nuclear euchromatin |
| CC | IEA | GO:0005759 | mitochondrial matrix |
| CC | IEA | GO:0030424 | axon |
| CC | IDA | GO:1990589 | ATF4-CREB1 transcription factor complex |
Gene expression in normal tissue: CREB1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CREB1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | arenrf2pathway | oxidative stress induced gene expression via nrf2 |
| biocarta | cacampathway | ca-calmodulin-dependent protein kinase activation |
| biocarta | carm1pathway | transcription regulation by methyltransferase of carm1 |
| biocarta | crebpathway | transcription factor creb and its extracellular signals |
| biocarta | dreampathway | repression of pain sensation by the transcriptional regulator dream |
| biocarta | eponfkbpathway | erythropoietin mediated neuroprotection through nf-kb |
| biocarta | erk5pathway | role of erk5 in neuronal survival pathway |
| biocarta | gpcrpathway | signaling pathway from g-protein families |
| biocarta | hbxpathway | calcium signaling by hbx of hepatitis b virus |
| biocarta | hcmvpathway | human cytomegalovirus and map kinase pathways |
| biocarta | hifpathway | hypoxia-inducible factor in the cardivascular system |
| biocarta | huntingtonpathway | inhibition of huntingtons disease neurodegeneration by histone deacetylase inhibitors |
| biocarta | mapkpathway | mapkinase signaling pathway |
| biocarta | melanocytepathway | melanocyte development and pigmentation pathway |
| biocarta | p38mapkpathway | p38 mapk signaling pathway |
| reactome | R-HSA-111885 | Opioid Signalling |
| reactome | R-HSA-111931 | PKA-mediated phosphorylation of CREB |
| reactome | R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB |
| reactome | R-HSA-111933 | Calmodulin induced events |
| reactome | R-HSA-111996 | Ca-dependent events |
| reactome | R-HSA-111997 | CaM pathway |
| reactome | R-HSA-112040 | G-protein mediated events |
| reactome | R-HSA-112043 | PLC beta mediated events |
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1489509 | DAG and IP3 signaling |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-1592230 | Mitochondrial biogenesis |
| reactome | R-HSA-1592230 | Mitochondrial biogenesis |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-1980145 | Signaling by NOTCH2 |
| reactome | R-HSA-198693 | AKT phosphorylates targets in the nucleus |
| reactome | R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) |
| reactome | R-HSA-199920 | CREB phosphorylation |
| reactome | R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis |
| reactome | R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis |
| reactome | R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription |
| reactome | R-HSA-2219528 | PI3K/AKT Signaling in Cancer |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-375165 | NCAM signaling for neurite out-growth |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-400253 | Circadian Clock |
| reactome | R-HSA-400253 | Circadian Clock |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-438064 | Post NMDA receptor activation events |
| reactome | R-HSA-442717 | CREB phosphorylation through the activation of CaMKK |
| reactome | R-HSA-442720 | CREB phosphorylation through the activation of Adenylate Cyclase |
| reactome | R-HSA-442729 | CREB phosphorylation through the activation of CaMKII |
| reactome | R-HSA-442742 | CREB phosphorylation through the activation of Ras |
| reactome | R-HSA-442755 | Activation of NMDA receptor and postsynaptic events |
| reactome | R-HSA-448424 | Interleukin-17 signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases |
| reactome | R-HSA-450294 | MAP kinase activation |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer |
| reactome | R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
| smpdb | SMP00309 | Excitatory Neural Signalling Through 5-HTR 4 and Serotonin |
| smpdb | SMP00311 | Excitatory Neural Signalling Through 5-HTR 7 and Serotonin |
| smpdb | SMP00312 | Excitatory Neural Signalling Through 5-HTR 6 and Serotonin |
| smpdb | SMP00320 | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine |
| smpdb | SMP00321 | Intracellular Signalling Through Adenosine Receptor A2b and Adenosine |
| smpdb | SMP00333 | Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone |
| smpdb | SMP00335 | Intracellular Signalling Through Histamine H2 Receptor and Histamine |
| smpdb | SMP00338 | Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin |
| wikipathways | WP138 | Androgen receptor signaling pathway |
| wikipathways | WP1530 | miRNA Regulation of DNA Damage Response |
| wikipathways | WP1541 | Energy Metabolism |
| wikipathways | WP1545 | miRNAs involved in DNA damage response |
| wikipathways | WP1589 | Folate-Alcohol and Cancer Pathway Hypotheses |
| wikipathways | WP1982 | Sterol Regulatory Element-Binding Proteins (SREBP) signalling |
| wikipathways | WP1984 | Integrated Breast Cancer Pathway |
| wikipathways | WP2032 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP2035 | Follicle Stimulating Hormone (FSH) signaling pathway |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP2332 | Interleukin-11 Signaling Pathway |
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP2374 | Oncostatin M Signaling Pathway |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP2516 | ATM Signaling Pathway |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP2636 | Common Pathways Underlying Drug Addiction |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| wikipathways | WP3301 | MFAP5-mediated ovarian cancer cell motility and invasiveness |
| wikipathways | WP3584 | MECP2 and Associated Rett Syndrome |
| wikipathways | WP3599 | Transcription factor regulation in adipogenesis |
| wikipathways | WP3676 | BDNF-TrkB Signaling |
| wikipathways | WP3853 | ERK Pathway in Huntington,s Disease |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP391 | Mitochondrial Gene Expression |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP3946 | White fat cell differentiation |
| wikipathways | WP3995 | Prion disease pathway |
| wikipathways | WP400 | p38 MAPK Signaling Pathway |
| wikipathways | WP4008 | NO-cGMP-PKG mediated Neuroprotection |
| wikipathways | WP4149 | White fat cell differentiation |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4222 | Phosphodiesterases in neuronal function |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP45 | G1 to S cell cycle control |
| wikipathways | WP585 | Interferon type I signaling pathways |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| wikipathways | WP707 | DNA Damage Response |
| wikipathways | WP712 | Estrogen signaling pathway |
| wikipathways | WP722 | Serotonin HTR1 Group and FOS Pathway |
| wikipathways | WP734 | Serotonin Receptor 4-6-7 and NR3C Signaling |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04211 | Longevity regulating pathway - Homo sapiens (human) |
| kegg | hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04612 | Antigen processing and presentation - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| kegg | hsa04710 | Circadian rhythm - Homo sapiens (human) |
| kegg | hsa04713 | Circadian entrainment - Homo sapiens (human) |
| kegg | hsa04714 | Thermogenesis - Homo sapiens (human) |
| kegg | hsa04725 | Cholinergic synapse - Homo sapiens (human) |
| kegg | hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| kegg | hsa04911 | Insulin secretion - Homo sapiens (human) |
| kegg | hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| kegg | hsa04916 | Melanogenesis - Homo sapiens (human) |
| kegg | hsa04918 | Thyroid hormone synthesis - Homo sapiens (human) |
| kegg | hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
| kegg | hsa04924 | Renin secretion - Homo sapiens (human) |
| kegg | hsa04925 | Aldosterone synthesis and secretion - Homo sapiens (human) |
| kegg | hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| kegg | hsa04927 | Cortisol synthesis and secretion - Homo sapiens (human) |
| kegg | hsa04931 | Insulin resistance - Homo sapiens (human) |
| kegg | hsa04934 | Cushing,s syndrome - Homo sapiens (human) |
| kegg | hsa04962 | Vasopressin-regulated water reabsorption - Homo sapiens (human) |
| kegg | hsa05016 | Huntington,s disease - Homo sapiens (human) |
| kegg | hsa05030 | Cocaine addiction - Homo sapiens (human) |
| kegg | hsa05031 | Amphetamine addiction - Homo sapiens (human) |
| kegg | hsa05034 | Alcoholism - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| pid | ap1_pathway | AP-1 transcription factor network |
| pid | ar_nongenomic_pathway | Nongenotropic Androgen signaling |
| pid | atf2_pathway | ATF-2 transcription factor network |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | hif1_tfpathway | HIF-1-alpha transcription factor network |
| pid | hnf3bpathway | FOXA2 and FOXA3 transcription factor networks |
| pid | ilk_pathway | Integrin-linked kinase signaling |
| pid | lkb1_pathway | LKB1 signaling events |
| pid | lpa4_pathway | LPA4-mediated signaling events |
| pid | lymphangiogenesis_pathway | VEGFR3 signaling in lymphatic endothelium |
| pid | mapktrkpathway | Trk receptor signaling mediated by the MAPK pathway |
| pid | myc_represspathway | Validated targets of C-MYC transcriptional repression |
| pid | p38_mk2pathway | p38 signaling mediated by MAPKAP kinases |
| pid | p38alphabetadownstreampathway | Signaling mediated by p38-alpha and p38-beta |
| pid | pi3kplctrkpathway | Trk receptor signaling mediated by PI3K and PLC-gamma |
| pid | reg_gr_pathway | Glucocorticoid receptor regulatory network |
| pid | ret_pathway | Signaling events regulated by Ret tyrosine kinase |
| pid | smad2_3nuclearpathway | Regulation of nuclear SMAD2/3 signaling |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_BDNF | BDNF |
| netpath | Pathway_CRH | CRH |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_Gastrin | Gastrin |
| netpath | Pathway_Ghrelin | Ghrelin |
| netpath | Pathway_IL2 | IL2 |
| netpath | Pathway_IL3 | IL3 |
| netpath | Pathway_TCR | TCR |
| netpath | Pathway_TNFalpha | TNFalpha |
| netpath | Pathway_TSH | TSH |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD403 | BAY 61-3606 | 1 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD599 | Salermide | 1 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD177 | Teniposide | 6 |
| iGMDRD551 | Ponatinib | 1 |
| iGMDRD158 | NSC141540 | 4 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD291 | AC1NS4S0 | 1 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD506 | Fedratinib | 4 |
| iGMDRD391 | OSU-03012 | 1 |
| iGMDRD74 | Idarubicin | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CREB1
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.