CREB1

Summary: This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NamecAMP responsive element binding protein 1
OMIM IDMIM:123810
Ensembl IDEnsembl:ENSG00000118260
HGNC IDHGNC:HGNC:2345
PHARMGKB IDPA26864
Map Location2q33.3

GO terms in CREB1


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding
MF IDA GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
MF ISA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF ISM GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF NAS GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF IC GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
Showing 1 to 6 of 75 rows rows per page

Gene expression in normal tissue: CREB1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined13Other, kinases2ERK MAPK signaling1RTK signaling1PI3K/MTOR signaling1DNA replication1

Pathways in CREB1


Loading, please wait...
Database
Pathway ID
Pathway Des.
biocarta arenrf2pathway oxidative stress induced gene expression via nrf2
biocarta cacampathway ca-calmodulin-dependent protein kinase activation
biocarta carm1pathway transcription regulation by methyltransferase of carm1
biocarta crebpathway transcription factor creb and its extracellular signals
biocarta dreampathway repression of pain sensation by the transcriptional regulator dream
biocarta eponfkbpathway erythropoietin mediated neuroprotection through nf-kb
Showing 1 to 6 of 211 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD403 BAY 61-3606 1
iGMDRD560 MK-2206 3
iGMDRD599 Salermide 1
iGMDRD512 nutlin 3 3
Showing 1 to 4 of 19 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CREB1

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.