BRSK2
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| BR serine/threonine kinase 2 | MIM:609236 | Ensembl:ENSG00000174672 | HGNC:HGNC:11405 | PA36212 | 11p15.5 |
GO terms in BRSK2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006887 | exocytosis |
| BP | IBA | GO:0007409 | axonogenesis |
| BP | ISS | GO:0007409 | axonogenesis |
| BP | ISS | GO:0010975 | regulation of neuron projection development |
| BP | IEA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IBA | GO:0030010 | establishment of cell polarity |
| BP | ISS | GO:0030010 | establishment of cell polarity |
| BP | ISS | GO:0030182 | neuron differentiation |
| BP | IMP | GO:0031532 | actin cytoskeleton reorganization |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IMP | GO:0036503 | ERAD pathway |
| BP | NAS | GO:0043462 | regulation of ATPase activity |
| BP | ISS | GO:0050770 | regulation of axonogenesis |
| BP | IEA | GO:0051301 | cell division |
| BP | IMP | GO:0061178 | regulation of insulin secretion involved in cellular response to glucose stimulus |
| BP | ISS | GO:0061178 | regulation of insulin secretion involved in cellular response to glucose stimulus |
| BP | IMP | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| BP | ISS | GO:0090176 | microtubule cytoskeleton organization involved in establishment of planar polarity |
| BP | IC | GO:1904152 | regulation of retrograde protein transport, ER to cytosol |
| BP | NAS | GO:1904152 | regulation of retrograde protein transport, ER to cytosol |
| BP | TAS | GO:2000807 | regulation of synaptic vesicle clustering |
| CC | IBA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | IBA | GO:0005813 | centrosome |
| CC | IDA | GO:0005813 | centrosome |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| CC | ISS | GO:0150034 | distal axon |
| MF | IDA | GO:0000287 | magnesium ion binding |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | ISS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IEA | GO:0019901 | protein kinase binding |
| MF | IBA | GO:0050321 | tau-protein kinase activity |
| MF | IDA | GO:0050321 | tau-protein kinase activity |
| MF | ISS | GO:0050321 | tau-protein kinase activity |
| MF | IDA | GO:0051117 | ATPase binding |
| MF | NAS | GO:0060590 | ATPase regulator activity |
Gene expression in normal tissue: BRSK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD300 | Tozasertib | 6 |
| iGMDRD886 | Compound 1541A | 5 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD901 | ELCPK | 6 |
| iGMDRD883 | CIL55A | 1 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD150 | RITA | 2 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD60 | Quinoclamine | 1 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD782 | DC-45-A2 | 6 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD748 | PHA-665752 | 1 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD546 | BMS-754807 | 4 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD772 | BRD4770 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BRSK2
CLASSFICATION
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