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SCRIB

Summary: This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
scribbled planar cell polarity protein	MIM:607733	Ensembl:ENSG00000180900	HGNC:HGNC:30377	PA134936275	8q24.3

Gene Categories:

KINASE TUMOR SUPPRESSOR

GO terms in SCRIB

Term Type	Evidence Type	GO Term ID	GO Des.
CC	IDA	GO:0005654	nucleoplasm
CC	IDA	GO:0005886	plasma membrane
CC	IDA	GO:0005886	plasma membrane
CC	IBA	GO:0005911	cell-cell junction
CC	IDA	GO:0005911	cell-cell junction
CC	IBA	GO:0005913	cell-cell adherens junction
CC	IDA	GO:0005913	cell-cell adherens junction
CC	IBA	GO:0008328	ionotropic glutamate receptor complex
CC	IBA	GO:0014069	postsynaptic density
CC	IBA	GO:0016323	basolateral plasma membrane
CC	IEA	GO:0030027	lamellipodium
CC	IBA	GO:0030054	cell junction
CC	IDA	GO:0030054	cell junction
CC	IDA	GO:0031252	cell leading edge
CC	IDA	GO:0034750	Scrib-APC-beta-catenin complex
CC	IEA	GO:0035748	myelin sheath abaxonal region
CC	IDA	GO:0042734	presynaptic membrane
CC	IEA	GO:0044291	cell-cell contact zone
CC	IBA	GO:0045202	synapse
CC	IBA	GO:0045211	postsynaptic membrane
CC	IDA	GO:0045211	postsynaptic membrane
CC	HDA	GO:0070062	extracellular exosome
CC	IBA	GO:0097060	synaptic membrane
BP	IMP	GO:0001843	neural tube closure
BP	IMP	GO:0001921	positive regulation of receptor recycling
BP	IBA	GO:0007268	chemical synaptic transmission
BP	IDA	GO:0008283	cell proliferation
BP	IEA	GO:0016080	synaptic vesicle targeting
BP	IMP	GO:0016477	cell migration
BP	IEA	GO:0021747	cochlear nucleus development
BP	IMP	GO:0035089	establishment of apical/basal cell polarity
BP	IEA	GO:0039502	suppression by virus of host type I interferon-mediated signaling pathway
BP	IEA	GO:0039563	suppression by virus of host STAT1 activity
BP	IEA	GO:0039564	suppression by virus of host STAT2 activity
BP	IEA	GO:0042060	wound healing
BP	IMP	GO:0043065	positive regulation of apoptotic process
BP	IBA	GO:0043113	receptor clustering
BP	IEA	GO:0043615	astrocyte cell migration
BP	IBA	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity
BP	IDA	GO:0045930	negative regulation of mitotic cell cycle
BP	IEA	GO:0046037	GMP metabolic process
BP	IEA	GO:0046710	GDP metabolic process
BP	IEA	GO:0048488	synaptic vesicle endocytosis
BP	IMP	GO:0050918	positive chemotaxis
BP	IEA	GO:0060088	auditory receptor cell stereocilium organization
BP	IMP	GO:0060561	apoptotic process involved in morphogenesis
BP	ISS	GO:0060603	mammary gland duct morphogenesis
BP	IMP	GO:0071896	protein localization to adherens junction
BP	IMP	GO:0090630	activation of GTPase activity
BP	IBA	GO:0097120	receptor localization to synapse
BP	IGI	GO:0098609	cell-cell adhesion
BP	IBA	GO:0098887	neurotransmitter receptor transport, endosome to postsynaptic membrane
BP	IEA	GO:0098887	neurotransmitter receptor transport, endosome to postsynaptic membrane
BP	IBA	GO:0098968	neurotransmitter receptor transport postsynaptic membrane to endosome
BP	IEA	GO:0098968	neurotransmitter receptor transport postsynaptic membrane to endosome
MF	IPI	GO:0005515	protein binding
MF	IBA	GO:0035255	ionotropic glutamate receptor binding
MF	HDA	GO:0045296	cadherin binding

Gene expression in normal tissue: SCRIB

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SCRIB

Database	Pathway ID	Pathway Des.
wikipathways	WP2032	Human Thyroid Stimulating Hormone (TSH) signaling pathway
netpath	Pathway_EGFR1	EGFR1
netpath	Pathway_TSH	TSH
kegg	hsa04390	Hippo signaling pathway - Homo sapiens (human)
kegg	hsa04530	Tight junction - Homo sapiens (human)
kegg	hsa05165	Human papillomavirus infection - Homo sapiens (human)
kegg	hsa05203	Viral carcinogenesis - Homo sapiens (human)
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-195721	Signaling by WNT
reactome	R-HSA-3858494	Beta-catenin independent WNT signaling
reactome	R-HSA-4086400	PCP/CE pathway
reactome	R-HSA-4608870	Asymmetric localization of PCP proteins

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD886	Compound 1541A	2
iGMDRD23	Gossypol	3
iGMDRD444	Tivantinib	3
iGMDRD67	PENFLURIDOL	3
iGMDRD871	BRD6368	3
iGMDRD730	Kahalalide F	3
iGMDRD887	Compound 23 citrate	3
iGMDRD74	Idarubicin	2
iGMDRD506	Fedratinib	3
iGMDRD705	Nakiterpiosin	3
iGMDRD103	SN-38	2
iGMDRD121	GMX1778	3
iGMDRD158	NSC141540	3
iGMDRD211	(1S,3R)-RSL3	1
iGMDRD280	CYTOCHALASIN B	2
iGMDRD639	YK 4-279	2
iGMDRD61	Kinetin riboside	3
iGMDRD532	Olaparib	3
iGMDRD424	Tamatinib	2
iGMDRD781	Sirolimus	2
iGMDRD210	AC55649	2
iGMDRD512	nutlin 3	5

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SCRIB

SITE

DATATYPES

CLASSFICATION

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