SCRIB


Summary: This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
scribbled planar cell polarity proteinMIM:607733Ensembl:ENSG00000180900HGNC:HGNC:30377PA1349362758q24.3

Gene Categories:

KINASETUMOR SUPPRESSOR

GO terms in SCRIB


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005654nucleoplasm
CCIDAGO:0005886plasma membrane
CCIDAGO:0005886plasma membrane
CCIBAGO:0005911cell-cell junction
CCIDAGO:0005911cell-cell junction
CCIBAGO:0005913cell-cell adherens junction
CCIDAGO:0005913cell-cell adherens junction
CCIBAGO:0008328ionotropic glutamate receptor complex
CCIBAGO:0014069postsynaptic density
CCIBAGO:0016323basolateral plasma membrane
CCIEAGO:0030027lamellipodium
CCIBAGO:0030054cell junction
CCIDAGO:0030054cell junction
CCIDAGO:0031252cell leading edge
CCIDAGO:0034750Scrib-APC-beta-catenin complex
CCIEAGO:0035748myelin sheath abaxonal region
CCIDAGO:0042734presynaptic membrane
CCIEAGO:0044291cell-cell contact zone
CCIBAGO:0045202synapse
CCIBAGO:0045211postsynaptic membrane
CCIDAGO:0045211postsynaptic membrane
CCHDAGO:0070062extracellular exosome
CCIBAGO:0097060synaptic membrane
BPIMPGO:0001843neural tube closure
BPIMPGO:0001921positive regulation of receptor recycling
BPIBAGO:0007268chemical synaptic transmission
BPIDAGO:0008283cell proliferation
BPIEAGO:0016080synaptic vesicle targeting
BPIMPGO:0016477cell migration
BPIEAGO:0021747cochlear nucleus development
BPIMPGO:0035089establishment of apical/basal cell polarity
BPIEAGO:0039502suppression by virus of host type I interferon-mediated signaling pathway
BPIEAGO:0039563suppression by virus of host STAT1 activity
BPIEAGO:0039564suppression by virus of host STAT2 activity
BPIEAGO:0042060wound healing
BPIMPGO:0043065positive regulation of apoptotic process
BPIBAGO:0043113receptor clustering
BPIEAGO:0043615astrocyte cell migration
BPIBAGO:0045197establishment or maintenance of epithelial cell apical/basal polarity
BPIDAGO:0045930negative regulation of mitotic cell cycle
BPIEAGO:0046037GMP metabolic process
BPIEAGO:0046710GDP metabolic process
BPIEAGO:0048488synaptic vesicle endocytosis
BPIMPGO:0050918positive chemotaxis
BPIEAGO:0060088auditory receptor cell stereocilium organization
BPIMPGO:0060561apoptotic process involved in morphogenesis
BPISSGO:0060603mammary gland duct morphogenesis
BPIMPGO:0071896protein localization to adherens junction
BPIMPGO:0090630activation of GTPase activity
BPIBAGO:0097120receptor localization to synapse
BPIGIGO:0098609cell-cell adhesion
BPIBAGO:0098887neurotransmitter receptor transport, endosome to postsynaptic membrane
BPIEAGO:0098887neurotransmitter receptor transport, endosome to postsynaptic membrane
BPIBAGO:0098968neurotransmitter receptor transport postsynaptic membrane to endosome
BPIEAGO:0098968neurotransmitter receptor transport postsynaptic membrane to endosome
MFIPIGO:0005515protein binding
MFIBAGO:0035255ionotropic glutamate receptor binding
MFHDAGO:0045296cadherin binding

Gene expression in normal tissue: SCRIB

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SCRIB


DatabasePathway IDPathway Des.
wikipathwaysWP2032Human Thyroid Stimulating Hormone (TSH) signaling pathway
netpathPathway_EGFR1EGFR1
netpathPathway_TSHTSH
kegghsa04390Hippo signaling pathway - Homo sapiens (human)
kegghsa04530Tight junction - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-3858494Beta-catenin independent WNT signaling
reactomeR-HSA-4086400PCP/CE pathway
reactomeR-HSA-4608870Asymmetric localization of PCP proteins

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD886Compound 1541A2
iGMDRD23Gossypol3
iGMDRD444Tivantinib3
iGMDRD67PENFLURIDOL3
iGMDRD871BRD63683
iGMDRD730Kahalalide F3
iGMDRD887Compound 23 citrate3
iGMDRD74Idarubicin2
iGMDRD506Fedratinib3
iGMDRD705Nakiterpiosin3
iGMDRD103SN-382
iGMDRD121GMX17783
iGMDRD158NSC1415403
iGMDRD211(1S,3R)-RSL31
iGMDRD280CYTOCHALASIN B2
iGMDRD639YK 4-2792
iGMDRD61Kinetin riboside3
iGMDRD532Olaparib3
iGMDRD424Tamatinib2
iGMDRD781Sirolimus2
iGMDRD210AC556492
iGMDRD512nutlin 35

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SCRIB

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