SCRIB

Summary: This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namescribbled planar cell polarity protein
OMIM IDMIM:607733
Ensembl IDEnsembl:ENSG00000180900
HGNC IDHGNC:HGNC:30377
PHARMGKB IDPA134936275
Map Location8q24.3

Gene Categories:

KINASETUMOR SUPPRESSOR

GO terms in SCRIB


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0005654 nucleoplasm
CC IDA GO:0005886 plasma membrane
CC IDA GO:0005886 plasma membrane
CC IBA GO:0005911 cell-cell junction
CC IDA GO:0005911 cell-cell junction
CC IBA GO:0005913 cell-cell adherens junction
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Gene expression in normal tissue: SCRIB

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined14DNA replication2Genome integrity1Longevity regulating pathway1Ferroptosis1Other, kinases1Biosynthesis of secondary metabolites1RTK signaling1

Pathways in SCRIB


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Database
Pathway ID
Pathway Des.
wikipathways WP2032 Human Thyroid Stimulating Hormone (TSH) signaling pathway
netpath Pathway_EGFR1 EGFR1
netpath Pathway_TSH TSH
kegg hsa04390 Hippo signaling pathway - Homo sapiens (human)
kegg hsa04530 Tight junction - Homo sapiens (human)
kegg hsa05165 Human papillomavirus infection - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD886 Compound 1541A 2
iGMDRD23 Gossypol 3
iGMDRD444 Tivantinib 3
iGMDRD67 PENFLURIDOL 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SCRIB

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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