JAG2
Summary: The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| jagged 2 | MIM:602570 | Ensembl:ENSG00000184916 | HGNC:HGNC:6189 | PA29987 | 14q32.33 |
Gene Categories:
GROWTH FACTORGO terms in JAG2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005112 | Notch binding |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008083 | growth factor activity |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | ISS | GO:0005887 | integral component of plasma membrane |
| BP | IEA | GO:0001501 | skeletal system development |
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | IEA | GO:0003016 | respiratory system process |
| BP | NAS | GO:0007219 | Notch signaling pathway |
| BP | TAS | GO:0007219 | Notch signaling pathway |
| BP | IEP | GO:0007283 | spermatogenesis |
| BP | ISS | GO:0009912 | auditory receptor cell fate commitment |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IEA | GO:0016331 | morphogenesis of embryonic epithelium |
| BP | IDA | GO:0030154 | cell differentiation |
| BP | IEA | GO:0030155 | regulation of cell adhesion |
| BP | IDA | GO:0030217 | T cell differentiation |
| BP | IDA | GO:0042127 | regulation of cell proliferation |
| BP | IEA | GO:0042475 | odontogenesis of dentin-containing tooth |
| BP | IEA | GO:0042492 | gamma-delta T cell differentiation |
| BP | IDA | GO:0045061 | thymic T cell selection |
| BP | ISS | GO:0045747 | positive regulation of Notch signaling pathway |
| BP | IEA | GO:1990134 | epithelial cell apoptotic process involved in palatal shelf morphogenesis |
Gene expression in normal tissue: JAG2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in JAG2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP268 | Notch Signaling Pathway |
| wikipathways | WP3413 | NOTCH1 regulation of human endothelial cell calcification |
| wikipathways | WP3845 | Canonical and Non-canonical Notch signaling |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| wikipathways | WP4242 | Notch Signaling Pathway |
| wikipathways | WP61 | Notch Signaling Pathway |
| pid | notch_pathway | Notch signaling pathway |
| pid | p73pathway | p73 transcription factor network |
| netpath | Pathway_Notch | Notch |
| kegg | hsa04330 | Notch signaling pathway - Homo sapiens (human) |
| kegg | hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1980143 | Signaling by NOTCH1 |
| reactome | R-HSA-1980143 | Signaling by NOTCH1 |
| reactome | R-HSA-1980145 | Signaling by NOTCH2 |
| reactome | R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus |
| reactome | R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus |
| reactome | R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| reactome | R-HSA-2644603 | Signaling by NOTCH1 in Cancer |
| reactome | R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| reactome | R-HSA-2660825 | Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant |
| reactome | R-HSA-2660826 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant |
| reactome | R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer |
| reactome | R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants |
| reactome | R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| reactome | R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| reactome | R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-9012852 | Signaling by NOTCH3 |
| reactome | R-HSA-9012852 | Signaling by NOTCH3 |
| reactome | R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus |
| reactome | R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD499 | PDMP | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD883 | CIL55A | 3 |
| iGMDRD137 | Indisulam | 1 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD366 | PI-103 | 2 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD201 | SKI II | 2 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 2 |
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD270 | Ciclosporin | 2 |
| iGMDRD318 | PAC-1 | 6 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD60 | Quinoclamine | 6 |
| iGMDRD23 | Gossypol | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in JAG2
CLASSFICATION
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