JAG2


Summary: The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
jagged 2MIM:602570Ensembl:ENSG00000184916HGNC:HGNC:6189PA2998714q32.33

Gene Categories:

GROWTH FACTOR

GO terms in JAG2


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005112Notch binding
MFIEAGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
MFIDAGO:0008083growth factor activity
CCTASGO:0005886plasma membrane
CCISSGO:0005887integral component of plasma membrane
BPIEAGO:0001501skeletal system development
BPIEAGO:0001701in utero embryonic development
BPIEAGO:0003016respiratory system process
BPNASGO:0007219Notch signaling pathway
BPTASGO:0007219Notch signaling pathway
BPIEPGO:0007283spermatogenesis
BPISSGO:0009912auditory receptor cell fate commitment
BPIEAGO:0010469regulation of signaling receptor activity
BPIEAGO:0016331morphogenesis of embryonic epithelium
BPIDAGO:0030154cell differentiation
BPIEAGO:0030155regulation of cell adhesion
BPIDAGO:0030217T cell differentiation
BPIDAGO:0042127regulation of cell proliferation
BPIEAGO:0042475odontogenesis of dentin-containing tooth
BPIEAGO:0042492gamma-delta T cell differentiation
BPIDAGO:0045061thymic T cell selection
BPISSGO:0045747positive regulation of Notch signaling pathway
BPIEAGO:1990134epithelial cell apoptotic process involved in palatal shelf morphogenesis

Gene expression in normal tissue: JAG2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in JAG2


DatabasePathway IDPathway Des.
wikipathwaysWP268Notch Signaling Pathway
wikipathwaysWP3413NOTCH1 regulation of human endothelial cell calcification
wikipathwaysWP3845Canonical and Non-canonical Notch signaling
wikipathwaysWP4239EMT transition in Colorectal Cancer
wikipathwaysWP4242Notch Signaling Pathway
wikipathwaysWP61Notch Signaling Pathway
pidnotch_pathwayNotch signaling pathway
pidp73pathwayp73 transcription factor network
netpathPathway_NotchNotch
kegghsa04330Notch signaling pathway - Homo sapiens (human)
kegghsa04658Th1 and Th2 cell differentiation - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
reactomeR-HSA-157118Signaling by NOTCH
reactomeR-HSA-157118Signaling by NOTCH
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-1980143Signaling by NOTCH1
reactomeR-HSA-1980143Signaling by NOTCH1
reactomeR-HSA-1980145Signaling by NOTCH2
reactomeR-HSA-2122948Activated NOTCH1 Transmits Signal to the Nucleus
reactomeR-HSA-2122948Activated NOTCH1 Transmits Signal to the Nucleus
reactomeR-HSA-2644602Signaling by NOTCH1 PEST Domain Mutants in Cancer
reactomeR-HSA-2644603Signaling by NOTCH1 in Cancer
reactomeR-HSA-2644606Constitutive Signaling by NOTCH1 PEST Domain Mutants
reactomeR-HSA-2660825Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
reactomeR-HSA-2660826Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
reactomeR-HSA-2691230Signaling by NOTCH1 HD Domain Mutants in Cancer
reactomeR-HSA-2691232Constitutive Signaling by NOTCH1 HD Domain Mutants
reactomeR-HSA-2894858Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
reactomeR-HSA-2894862Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
reactomeR-HSA-2979096NOTCH2 Activation and Transmission of Signal to the Nucleus
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-9012852Signaling by NOTCH3
reactomeR-HSA-9012852Signaling by NOTCH3
reactomeR-HSA-9013507NOTCH3 Activation and Transmission of Signal to the Nucleus
reactomeR-HSA-9013507NOTCH3 Activation and Transmission of Signal to the Nucleus

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD85Ursolic acid3
iGMDRD499PDMP3
iGMDRD945ML2143
iGMDRD883CIL55A3
iGMDRD137Indisulam1
iGMDRD289Parthenolide1
iGMDRD434BMS-5369243
iGMDRD213SMR0000686502
iGMDRD77Itraconazole3
iGMDRD871BRD63683
iGMDRD872BRD71373
iGMDRD329Merck602
iGMDRD366PI-1032
iGMDRD300Tozasertib3
iGMDRD82Quiflapon2
iGMDRD772BRD47702
iGMDRD579PF7502
iGMDRD483SCH-5290743
iGMDRD201SKI II2
iGMDRD316N9-Isopropyl-olomoucine2
iGMDRD679Bistramide A3
iGMDRD280CYTOCHALASIN B3
iGMDRD270Ciclosporin2
iGMDRD318PAC-16
iGMDRD52Rotenone2
iGMDRD100Zebularine2
iGMDRD887Compound 23 citrate2
iGMDRD74Idarubicin2
iGMDRD506Fedratinib3
iGMDRD888Compound 441
iGMDRD577BIX012943
iGMDRD562Navitoclax3
iGMDRD60Quinoclamine6
iGMDRD23Gossypol2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in JAG2

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