JAG2

Summary: The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namejagged 2
OMIM IDMIM:602570
Ensembl IDEnsembl:ENSG00000184916
HGNC IDHGNC:HGNC:6189
PHARMGKB IDPA29987
Map Location14q32.33

Gene Categories:

GROWTH FACTOR

GO terms in JAG2


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005112 Notch binding
MF IEA GO:0005509 calcium ion binding
MF IPI GO:0005515 protein binding
MF IDA GO:0008083 growth factor activity
CC TAS GO:0005886 plasma membrane
CC ISS GO:0005887 integral component of plasma membrane
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Gene expression in normal tissue: JAG2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined25Biosynthesis of secondary metabolites2Apoptosis regulation2Other, kinases1Mitosis1Chromatin histone acetylation1PI3K/MTOR signaling1Th17 cell differentiation1

Pathways in JAG2


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Database
Pathway ID
Pathway Des.
wikipathways WP268 Notch Signaling Pathway
wikipathways WP3413 NOTCH1 regulation of human endothelial cell calcification
wikipathways WP3845 Canonical and Non-canonical Notch signaling
wikipathways WP4239 EMT transition in Colorectal Cancer
wikipathways WP4242 Notch Signaling Pathway
wikipathways WP61 Notch Signaling Pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD85 Ursolic acid 3
iGMDRD499 PDMP 3
iGMDRD945 ML214 3
iGMDRD883 CIL55A 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in JAG2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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