PTPRT


Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
protein tyrosine phosphatase, receptor type TMIM:608712Ensembl:ENSG00000196090HGNC:HGNC:9682PA3402720q12-q13.11

GO terms in PTPRT


Term TypeEvidence TypeGO Term IDGO Des.
MFIMPGO:0004725protein tyrosine phosphatase activity
MFIPIGO:0005515protein binding
MFIPIGO:0008013beta-catenin binding
MFIDAGO:0045294alpha-catenin binding
MFIDAGO:0045295gamma-catenin binding
MFIPIGO:0045296cadherin binding
MFIPIGO:0070097delta-catenin binding
BPIDAGO:0006470protein dephosphorylation
BPNASGO:0007155cell adhesion
BPIDAGO:0007156homophilic cell adhesion via plasma membrane adhesion molecules
BPNASGO:0007165signal transduction
BPIMPGO:0007169transmembrane receptor protein tyrosine kinase signaling pathway
BPIEAGO:0035335peptidyl-tyrosine dephosphorylation
CCIDAGO:0005886plasma membrane
CCIDAGO:0009986cell surface
CCNASGO:0016021integral component of membrane

Gene expression in normal tissue: PTPRT

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PTPRT


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD294Batimastat3
iGMDRD8012,4-dideoxy-DC-45-A22
iGMDRD782DC-45-A21
iGMDRD138PX 121
iGMDRD451Serdemetan3
iGMDRD64Parbendazole2
iGMDRD369TGX-1151
iGMDRD562Navitoclax4
iGMDRD780PP-301
iGMDRD506Fedratinib2
iGMDRD74Idarubicin3
iGMDRD887Compound 23 citrate3
iGMDRD399Selumetinib2
iGMDRD188Piperlongumine6
iGMDRD266Cucurbitacin I1
iGMDRD483SCH-5290741
iGMDRD494Neopeltolide4
iGMDRD546BMS-7548072
iGMDRD144NSC953972
iGMDRD427ABT7372
iGMDRD889Compound 7d-cis2
iGMDRD151CHM-15
iGMDRD76Simvastatin2
iGMDRD126Tipifarnib2
iGMDRD375GW-4058331
iGMDRD634SCHEMBL26080411
iGMDRD679Bistramide A1
iGMDRD297Austocystin D6
iGMDRD61Kinetin riboside2
iGMDRD201SKI II5
iGMDRD446LY 21832403
iGMDRD481Dactolisib1
iGMDRD434BMS-5369241
iGMDRD289Parthenolide4
iGMDRD139Fumagillol3
iGMDRD137Indisulam4
iGMDRD121GMX17782
iGMDRD103SN-381
iGMDRD42Vorinostat5
iGMDRD300Tozasertib4
iGMDRD329Merck608
iGMDRD872BRD71375
iGMDRD871BRD63682
iGMDRD367Ro 28-16751
iGMDRD286Nsc 6328392
iGMDRD652UNC06382
iGMDRD701NVP-AUY9222
iGMDRD79Gemcitabine2
iGMDRD150RITA4
iGMDRD512nutlin 33
iGMDRD177Teniposide3
iGMDRD123Isoevodiamine1
iGMDRD341Triacsin c5
iGMDRD223Stattic1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PTPRT

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