PLCG1
Summary: The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:172420 Ensembl IDEnsembl:ENSG00000124181 HGNC IDHGNC:HGNC:9065 PHARMGKB IDPA33392 Map Location20q12 | |||||
GO terms in PLCG1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IMP | GO:0007173 | epidermal growth factor receptor signaling pathway |
| BP | TAS | GO:0007202 | activation of phospholipase C activity |
| BP | TAS | GO:0007411 | axon guidance |
| BP | IEA | GO:0009395 | phospholipid catabolic process |
Gene expression in normal tissue: PLCG1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PLCG1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA152530845 | Proton Pump Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA2032 | VEGF Signaling Pathway |
| pid | ar_nongenomic_pathway | Nongenotropic Androgen signaling |
| pid | cd8tcrpathway | TCR signaling in naïve CD8+ T cells |
| pid | cdc42_reg_pathway | Regulation of CDC42 activity |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PLCG1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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