NCAPD3
Summary: Condensin complexes I and II play essential roles in mitotic chromosome assembly and segregation. Both condensins contain 2 invariant structural maintenance of chromosome (SMC) subunits, SMC2 (MIM 605576) and SMC4 (MIM 605575), but they contain different sets of non-SMC subunits. NCAPD3 is 1 of 3 non-SMC subunits that define condensin II (Ono et al., 2003 [PubMed 14532007]).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| non-SMC condensin II complex subunit D3 | MIM:609276 | Ensembl:ENSG00000151503 | HGNC:HGNC:28952 | PA162397090 | 11q25 |
GO terms in NCAPD3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0000779 | condensed chromosome, centromeric region |
| CC | IBA | GO:0000799 | nuclear condensin complex |
| CC | IDA | GO:0000799 | nuclear condensin complex |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0031618 | nuclear pericentric heterochromatin |
| BP | IBA | GO:0007076 | mitotic chromosome condensation |
| BP | IDA | GO:0007076 | mitotic chromosome condensation |
| BP | IBA | GO:0010032 | meiotic chromosome condensation |
| BP | IEA | GO:0051301 | cell division |
| BP | IBA | GO:0051304 | chromosome separation |
| MF | IBA | GO:0003682 | chromatin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0035064 | methylated histone binding |
| MF | IBA | GO:0042393 | histone binding |
Gene expression in normal tissue: NCAPD3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NCAPD3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-2299718 | Condensation of Prophase Chromosomes |
| reactome | R-HSA-68875 | Mitotic Prophase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD74 | Idarubicin | 4 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD441 | TW 37 | 2 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD484 | Pluripotin | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD599 | Salermide | 4 |
| iGMDRD420 | Leucascandrolide A | 4 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD329 | Merck60 | 1 |
| iGMDRD366 | PI-103 | 2 |
| iGMDRD705 | Nakiterpiosin | 5 |
| iGMDRD267 | Oligomycin A | 6 |
| iGMDRD213 | SMR000068650 | 3 |
| iGMDRD103 | SN-38 | 6 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD314 | Tanespimycin | 1 |
| iGMDRD698 | Neratinib | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD351 | GW843682X | 5 |
| iGMDRD150 | RITA | 2 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD584 | VER 155008 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NCAPD3
CLASSFICATION
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