NCAPD3

Summary: Condensin complexes I and II play essential roles in mitotic chromosome assembly and segregation. Both condensins contain 2 invariant structural maintenance of chromosome (SMC) subunits, SMC2 (MIM 605576) and SMC4 (MIM 605575), but they contain different sets of non-SMC subunits. NCAPD3 is 1 of 3 non-SMC subunits that define condensin II (Ono et al., 2003 [PubMed 14532007]).[supplied by OMIM, Mar 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namenon-SMC condensin II complex subunit D3
OMIM IDMIM:609276
Ensembl IDEnsembl:ENSG00000151503
HGNC IDHGNC:HGNC:28952
PHARMGKB IDPA162397090
Map Location11q25

GO terms in NCAPD3


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IBA GO:0000779 condensed chromosome, centromeric region
CC IBA GO:0000799 nuclear condensin complex
CC IDA GO:0000799 nuclear condensin complex
CC IDA GO:0005654 nucleoplasm
CC TAS GO:0005654 nucleoplasm
CC HDA GO:0016020 membrane
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Gene expression in normal tissue: NCAPD3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NCAPD3


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1640170 Cell Cycle
reactome R-HSA-2299718 Condensation of Prophase Chromosomes
reactome R-HSA-68875 Mitotic Prophase
reactome R-HSA-68886 M Phase
reactome R-HSA-69278 Cell Cycle, Mitotic
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD64 Parbendazole 2
iGMDRD188 Piperlongumine 5
iGMDRD74 Idarubicin 4
iGMDRD562 Navitoclax 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NCAPD3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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