LDLR


Summary: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010].

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Name
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Ensembl ID
HGNC ID
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GO terms in LDLR


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0001540 amyloid-beta binding
MF IEA GO:0001618 virus receptor activity
MF IPI GO:0002020 protease binding
MF IC GO:0005041 low-density lipoprotein particle receptor activity
MF IDA GO:0005041 low-density lipoprotein particle receptor activity
MF IMP GO:0005041 low-density lipoprotein particle receptor activity
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Gene expression in normal tissue: LDLR

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LDLR


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1430728 Metabolism
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance
reactome R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance
reactome R-HSA-196854 Metabolism of vitamins and cofactors
reactome R-HSA-199991 Membrane Trafficking
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD512 nutlin 3 1
iGMDRD523 Cyanoquinoline, 11 3
iGMDRD405 PIK-75 2
iGMDRD341 Triacsin c 8
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LDLR

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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