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TEX14

Summary: The protein encoded by this gene is necessary for intercellular bridges in germ cells, which are required for spermatogenesis. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
testis expressed 14, intercellular bridge forming factor	MIM:605792	Ensembl:ENSG00000121101	HGNC:HGNC:11737	PA36454	17q22

Gene Categories:

TUMOR SUPPRESSOR KINASE TYROSINE KINASE DRUGGABLE GENOME

GO terms in TEX14

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IEA	GO:0004672	protein kinase activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005524	ATP binding
MF	IPI	GO:0019901	protein kinase binding
BP	IEA	GO:0006468	protein phosphorylation
BP	IBA	GO:0007094	mitotic spindle assembly checkpoint
BP	ISS	GO:0007094	mitotic spindle assembly checkpoint
BP	IBA	GO:0007140	male meiotic nuclear division
BP	ISS	GO:0007140	male meiotic nuclear division
BP	IBA	GO:0008608	attachment of spindle microtubules to kinetochore
BP	ISS	GO:0008608	attachment of spindle microtubules to kinetochore
BP	IEA	GO:0032091	negative regulation of protein binding
BP	IEA	GO:0032466	negative regulation of cytokinesis
BP	IBA	GO:0043063	intercellular bridge organization
BP	ISS	GO:0043063	intercellular bridge organization
BP	IEA	GO:0051301	cell division
BP	IBA	GO:0051306	mitotic sister chromatid separation
BP	ISS	GO:0051306	mitotic sister chromatid separation
BP	IEA	GO:1990830	cellular response to leukemia inhibitory factor
CC	IBA	GO:0000776	kinetochore
CC	ISS	GO:0000776	kinetochore
CC	IEA	GO:0000777	condensed chromosome kinetochore
CC	ISS	GO:0005623	cell
CC	IEA	GO:0005737	cytoplasm
CC	IBA	GO:0030496	midbody
CC	ISS	GO:0030496	midbody
CC	IBA	GO:0045171	intercellular bridge
CC	ISS	GO:0045171	intercellular bridge
CC	HDA	GO:0070062	extracellular exosome

Gene expression in normal tissue: TEX14

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TEX14

Database	Pathway ID	Pathway Des.

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD322	FK 866	4
iGMDRD82	Quiflapon	2
iGMDRD505	Pevonedistat	3
iGMDRD300	Tozasertib	3
iGMDRD329	Merck60	2
iGMDRD286	Nsc 632839	3
iGMDRD77	Itraconazole	2
iGMDRD213	SMR000068650	2
iGMDRD705	Nakiterpiosin	3
iGMDRD158	NSC141540	1
iGMDRD137	Indisulam	3
iGMDRD435	BI-2536	3
iGMDRD123	Isoevodiamine	3
iGMDRD57	Chloropentafluorobenzene	3
iGMDRD314	Tanespimycin	2
iGMDRD85	Ursolic acid	1
iGMDRD424	Tamatinib	3
iGMDRD512	nutlin 3	2
iGMDRD307	Manumycin A	3
iGMDRD60	Quinoclamine	3
iGMDRD780	PP-30	3
iGMDRD562	Navitoclax	6
iGMDRD888	Compound 44	1
iGMDRD399	Selumetinib	1
iGMDRD74	Idarubicin	4
iGMDRD100	Zebularine	2
iGMDRD52	Rotenone	5
iGMDRD441	TW 37	5
iGMDRD634	SCHEMBL2608041	3
iGMDRD316	N9-Isopropyl-olomoucine	2
iGMDRD201	SKI II	2
iGMDRD781	Sirolimus	5
iGMDRD546	BMS-754807	5
iGMDRD427	ABT737	6
iGMDRD579	PF750	2
iGMDRD772	BRD4770	4
iGMDRD126	Tipifarnib	6

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TEX14

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.