LASP1
Summary: This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| LIM and SH3 protein 1 | MIM:602920 | Ensembl:ENSG00000002834 | HGNC:HGNC:6513 | PA30298 | 17q12 |
Gene Categories:
TRANSPORTERGO terms in LASP1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0005070 | SH3/SH2 adaptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0015075 | ion transmembrane transporter activity |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IEA | GO:0051015 | actin filament binding |
| BP | ISS | GO:0006811 | ion transport |
| BP | IEA | GO:0009967 | positive regulation of signal transduction |
| BP | IEA | GO:0034220 | ion transmembrane transport |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | ISS | GO:0030864 | cortical actin cytoskeleton |
Gene expression in normal tissue: LASP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LASP1
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD351 | GW843682X | 6 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD300 | Tozasertib | 5 |
| iGMDRD105 | Triptolide | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LASP1
CLASSFICATION
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