HIPK1
Summary: The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| homeodomain interacting protein kinase 1 | MIM:608003 | Ensembl:ENSG00000163349 | HGNC:HGNC:19006 | PA134897980 | 1p13.2 |
GO terms in HIPK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005813 | centrosome |
| CC | IDA | GO:0005829 | cytosol |
| CC | IEA | GO:0016605 | PML body |
| CC | IEA | GO:0016607 | nuclear speck |
| BP | ISS | GO:0001654 | eye development |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0007224 | smoothened signaling pathway |
| BP | IEA | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0009952 | anterior/posterior pattern specification |
| BP | IDA | GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway |
| BP | IEA | GO:0010842 | retina layer formation |
| BP | IEA | GO:0030182 | neuron differentiation |
| BP | IEA | GO:0034333 | adherens junction assembly |
| BP | IEA | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| BP | ISS | GO:0045766 | positive regulation of angiogenesis |
| BP | IEA | GO:0048596 | embryonic camera-type eye morphogenesis |
| BP | IEA | GO:0060059 | embryonic retina morphogenesis in camera-type eye |
| BP | ISS | GO:0060216 | definitive hemopoiesis |
| BP | IEA | GO:0060235 | lens induction in camera-type eye |
| BP | IEA | GO:0061072 | iris morphogenesis |
| BP | IDA | GO:0072577 | endothelial cell apoptotic process |
| BP | IDA | GO:0097191 | extrinsic apoptotic signaling pathway |
| BP | TAS | GO:1901796 | regulation of signal transduction by p53 class mediator |
| MF | IEA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
Gene expression in normal tissue: HIPK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HIPK1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| wikipathways | WP3938 | miR-222 in Exercise-Induced Cardiac Growth |
| reactome | R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-397014 | Muscle contraction |
| reactome | R-HSA-5576891 | Cardiac conduction |
| reactome | R-HSA-5578768 | Physiological factors |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD280 | CYTOCHALASIN B | 6 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD584 | VER 155008 | 1 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD484 | Pluripotin | 6 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD494 | Neopeltolide | 1 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD871 | BRD6368 | 6 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD52 | Rotenone | 4 |
| iGMDRD434 | BMS-536924 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HIPK1
CLASSFICATION
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