HIPK1
Summary: The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
homeodomain interacting protein kinase 1 | MIM:608003 | Ensembl:ENSG00000163349 | HGNC:HGNC:19006 | PA134897980 | 1p13.2 |
GO terms in HIPK1
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | IDA | GO:0005634 | nucleus |
CC | IDA | GO:0005654 | nucleoplasm |
CC | TAS | GO:0005654 | nucleoplasm |
CC | IDA | GO:0005737 | cytoplasm |
CC | IDA | GO:0005813 | centrosome |
CC | IDA | GO:0005829 | cytosol |
CC | IEA | GO:0016605 | PML body |
CC | IEA | GO:0016607 | nuclear speck |
BP | ISS | GO:0001654 | eye development |
BP | IEA | GO:0006351 | transcription, DNA-templated |
BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
BP | IEA | GO:0006468 | protein phosphorylation |
BP | IEA | GO:0007224 | smoothened signaling pathway |
BP | IEA | GO:0008284 | positive regulation of cell proliferation |
BP | IEA | GO:0009952 | anterior/posterior pattern specification |
BP | IDA | GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway |
BP | IEA | GO:0010842 | retina layer formation |
BP | IEA | GO:0030182 | neuron differentiation |
BP | IEA | GO:0034333 | adherens junction assembly |
BP | IEA | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
BP | ISS | GO:0045766 | positive regulation of angiogenesis |
BP | IEA | GO:0048596 | embryonic camera-type eye morphogenesis |
BP | IEA | GO:0060059 | embryonic retina morphogenesis in camera-type eye |
BP | ISS | GO:0060216 | definitive hemopoiesis |
BP | IEA | GO:0060235 | lens induction in camera-type eye |
BP | IEA | GO:0061072 | iris morphogenesis |
BP | IDA | GO:0072577 | endothelial cell apoptotic process |
BP | IDA | GO:0097191 | extrinsic apoptotic signaling pathway |
BP | TAS | GO:1901796 | regulation of signal transduction by p53 class mediator |
MF | IEA | GO:0004674 | protein serine/threonine kinase activity |
MF | IPI | GO:0005515 | protein binding |
MF | IEA | GO:0005524 | ATP binding |
Gene expression in normal tissue: HIPK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HIPK1
Database | Pathway ID | Pathway Des. |
---|---|---|
kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
wikipathways | WP3938 | miR-222 in Exercise-Induced Cardiac Growth |
reactome | R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression |
reactome | R-HSA-212436 | Generic Transcription Pathway |
reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
reactome | R-HSA-397014 | Muscle contraction |
reactome | R-HSA-5576891 | Cardiac conduction |
reactome | R-HSA-5578768 | Physiological factors |
reactome | R-HSA-5633007 | Regulation of TP53 Activity |
reactome | R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation |
reactome | R-HSA-73857 | RNA Polymerase II Transcription |
reactome | R-HSA-74160 | Gene expression (Transcription) |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD85 | Ursolic acid | 1 |
iGMDRD280 | CYTOCHALASIN B | 6 |
iGMDRD394 | BX-795 | 3 |
iGMDRD599 | Salermide | 3 |
iGMDRD584 | VER 155008 | 1 |
iGMDRD330 | BRD4132 | 3 |
iGMDRD84 | Lovastatin acid | 3 |
iGMDRD484 | Pluripotin | 6 |
iGMDRD523 | Cyanoquinoline, 11 | 3 |
iGMDRD494 | Neopeltolide | 1 |
iGMDRD144 | NSC95397 | 3 |
iGMDRD662 | JQ-1 | 3 |
iGMDRD871 | BRD6368 | 6 |
iGMDRD356 | PNU-74654 | 3 |
iGMDRD52 | Rotenone | 4 |
iGMDRD434 | BMS-536924 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HIPK1