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HIPK1

Summary: The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namehomeodomain interacting protein kinase 1 OMIM IDMIM:608003 Ensembl IDEnsembl:ENSG00000163349 HGNC IDHGNC:HGNC:19006 PHARMGKB IDPA134897980 Map Location1p13.2

Gene Categories:

DRUGGABLE GENOME SERINE THREONINE KINASE KINASE

GO terms in HIPK1

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Term Type	Evidence Type	GO Term ID	GO Des.
CC	IDA	GO:0005634	nucleus
CC	IDA	GO:0005654	nucleoplasm
CC	TAS	GO:0005654	nucleoplasm
CC	IDA	GO:0005737	cytoplasm
CC	IDA	GO:0005813	centrosome
CC	IDA	GO:0005829	cytosol

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Gene expression in normal tissue: HIPK1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HIPK1

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Database	Pathway ID	Pathway Des.
kegg	hsa04218	Cellular senescence - Homo sapiens (human)
wikipathways	WP3938	miR-222 in Exercise-Induced Cardiac Growth
reactome	R-HSA-2032785	YAP1- and WWTR1 (TAZ)-stimulated gene expression
reactome	R-HSA-212436	Generic Transcription Pathway
reactome	R-HSA-3700989	Transcriptional Regulation by TP53
reactome	R-HSA-397014	Muscle contraction

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD85	Ursolic acid	1
iGMDRD280	CYTOCHALASIN B	6
iGMDRD394	BX-795	3
iGMDRD599	Salermide	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HIPK1

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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