HIPK1


Summary: The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
homeodomain interacting protein kinase 1MIM:608003Ensembl:ENSG00000163349HGNC:HGNC:19006PA1348979801p13.2

GO terms in HIPK1


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCIDAGO:0005813centrosome
CCIDAGO:0005829cytosol
CCIEAGO:0016605PML body
CCIEAGO:0016607nuclear speck
BPISSGO:0001654eye development
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006355regulation of transcription, DNA-templated
BPIEAGO:0006468protein phosphorylation
BPIEAGO:0007224smoothened signaling pathway
BPIEAGO:0008284positive regulation of cell proliferation
BPIEAGO:0009952anterior/posterior pattern specification
BPIDAGO:0010803regulation of tumor necrosis factor-mediated signaling pathway
BPIEAGO:0010842retina layer formation
BPIEAGO:0030182neuron differentiation
BPIEAGO:0034333adherens junction assembly
BPIEAGO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
BPISSGO:0045766positive regulation of angiogenesis
BPIEAGO:0048596embryonic camera-type eye morphogenesis
BPIEAGO:0060059embryonic retina morphogenesis in camera-type eye
BPISSGO:0060216definitive hemopoiesis
BPIEAGO:0060235lens induction in camera-type eye
BPIEAGO:0061072iris morphogenesis
BPIDAGO:0072577endothelial cell apoptotic process
BPIDAGO:0097191extrinsic apoptotic signaling pathway
BPTASGO:1901796regulation of signal transduction by p53 class mediator
MFIEAGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding

Gene expression in normal tissue: HIPK1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HIPK1


DatabasePathway IDPathway Des.
kegghsa04218Cellular senescence - Homo sapiens (human)
wikipathwaysWP3938miR-222 in Exercise-Induced Cardiac Growth
reactomeR-HSA-2032785YAP1- and WWTR1 (TAZ)-stimulated gene expression
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-397014Muscle contraction
reactomeR-HSA-5576891Cardiac conduction
reactomeR-HSA-5578768Physiological factors
reactomeR-HSA-5633007Regulation of TP53 Activity
reactomeR-HSA-6804756Regulation of TP53 Activity through Phosphorylation
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD85Ursolic acid1
iGMDRD280CYTOCHALASIN B6
iGMDRD394BX-7953
iGMDRD599Salermide3
iGMDRD584VER 1550081
iGMDRD330BRD41323
iGMDRD84Lovastatin acid3
iGMDRD484Pluripotin6
iGMDRD523Cyanoquinoline, 113
iGMDRD494Neopeltolide1
iGMDRD144NSC953973
iGMDRD662JQ-13
iGMDRD871BRD63686
iGMDRD356PNU-746543
iGMDRD52Rotenone4
iGMDRD434BMS-5369243

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HIPK1

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