SEARCH

HOME / SEARCH / TIE1

TIE1

Summary: This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].

Loading, please wait...

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nametyrosine kinase with immunoglobulin like and EGF like domains 1 OMIM IDMIM:600222 Ensembl IDEnsembl:ENSG00000066056 HGNC IDHGNC:HGNC:11809 PHARMGKB IDPA36516 Map Location1p34.2

Gene Categories:

KINASE TYROSINE KINASE DRUGGABLE GENOME

GO terms in TIE1

Loading, please wait...

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IBA	GO:0004709	MAP kinase kinase kinase activity
MF	IBA	GO:0004713	protein tyrosine kinase activity
MF	IBA	GO:0004714	transmembrane receptor protein tyrosine kinase activity
MF	IEA	GO:0004714	transmembrane receptor protein tyrosine kinase activity
MF	IBA	GO:0004888	transmembrane signaling receptor activity
MF	IPI	GO:0005515	protein binding

Showing 1 to 6 of 29 rows rows per page

Gene expression in normal tissue: TIE1

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TIE1

Loading, please wait...

Database	Pathway ID	Pathway Des.
wikipathways	WP3303	Rac1-Pak1-p38-MMP-2 pathway

Showing 1 to 1 of 1 rows

Gene-Drug: Aster Plot

Loading, please wait...

Drug ID	Drug Name	Model Num.
iGMDRD506	Fedratinib	3
iGMDRD780	PP-30	2
iGMDRD188	Piperlongumine	6
iGMDRD399	Selumetinib	3

Showing 1 to 4 of 75 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TIE1

Loading, please wait...

	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
No matching records found

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.