TENM1
Summary: The protein encoded by this gene belongs to the tenascin family and teneurin subfamily. It is expressed in the neurons and may function as a cellular signal transducer. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| teneurin transmembrane protein 1 | MIM:300588 | Ensembl:ENSG00000009694 | HGNC:HGNC:8117 | PA31904 | Xq25 |
GO terms in TENM1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005576 | extracellular region |
| CC | ISS | GO:0005634 | nucleus |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005783 | endoplasmic reticulum |
| CC | ISS | GO:0005794 | Golgi apparatus |
| CC | ISS | GO:0005856 | cytoskeleton |
| CC | ISS | GO:0005886 | plasma membrane |
| CC | ISS | GO:0005887 | integral component of plasma membrane |
| CC | ISS | GO:0016363 | nuclear matrix |
| CC | ISS | GO:0016607 | nuclear speck |
| CC | IBA | GO:0043005 | neuron projection |
| CC | ISS | GO:0048471 | perinuclear region of cytoplasm |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | ISS | GO:0006359 | regulation of transcription by RNA polymerase III |
| BP | TAS | GO:0006955 | immune response |
| BP | IBA | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules |
| BP | IEA | GO:0007218 | neuropeptide signaling pathway |
| BP | TAS | GO:0007399 | nervous system development |
| BP | TAS | GO:0008285 | negative regulation of cell proliferation |
| BP | ISS | GO:0030838 | positive regulation of actin filament polymerization |
| BP | ISS | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| BP | ISS | GO:0043406 | positive regulation of MAP kinase activity |
| BP | IBA | GO:0048666 | neuron development |
| BP | ISS | GO:0051491 | positive regulation of filopodium assembly |
| BP | ISS | GO:0090316 | positive regulation of intracellular protein transport |
| MF | TAS | GO:0008201 | heparin binding |
| MF | IBA | GO:0042803 | protein homodimerization activity |
| MF | ISS | GO:0042803 | protein homodimerization activity |
| MF | IBA | GO:0046982 | protein heterodimerization activity |
| MF | ISS | GO:0046982 | protein heterodimerization activity |
| MF | IBA | GO:0050839 | cell adhesion molecule binding |
Gene expression in normal tissue: TENM1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TENM1
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD322 | FK 866 | 2 |
| iGMDRD300 | Tozasertib | 4 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD505 | Pevonedistat | 8 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD662 | JQ-1 | 4 |
| iGMDRD286 | Nsc 632839 | 1 |
| iGMDRD871 | BRD6368 | 5 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD267 | Oligomycin A | 7 |
| iGMDRD105 | Triptolide | 1 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD202 | Curcumin | 1 |
| iGMDRD121 | GMX1778 | 1 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD435 | BI-2536 | 3 |
| iGMDRD698 | Neratinib | 2 |
| iGMDRD219 | Bax channel blocker | 4 |
| iGMDRD341 | Triacsin c | 4 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD523 | Cyanoquinoline, 11 | 2 |
| iGMDRD532 | Olaparib | 2 |
| iGMDRD150 | RITA | 2 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD512 | nutlin 3 | 4 |
| iGMDRD23 | Gossypol | 8 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD506 | Fedratinib | 5 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD887 | Compound 23 citrate | 7 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD297 | Austocystin D | 5 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD152 | 179324-69-7 | 5 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD144 | NSC95397 | 1 |
| iGMDRD546 | BMS-754807 | 4 |
| iGMDRD427 | ABT737 | 5 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD151 | CHM-1 | 8 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TENM1
CLASSFICATION
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