ADGRG4
Summary: This gene encodes a G-protein coupled receptor belonging to a large family of diverse integral membrane proteins that participate in various physiological functions. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The ligand for this family member is unknown, and it is therefore an orphan receptor. This receptor is known to be expressed in normal enterochromaffin cells and in gastrointestinal neuroendocrine carcinoma cells, and it is therefore considered to be a novel biomarker or target for immunotherapy. [provided by RefSeq, May 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| adhesion G protein-coupled receptor G4 | Ensembl:ENSG00000156920 | HGNC:HGNC:18992 | PA134885132 | Xq26.3 |
GO terms in ADGRG4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0001965 | G-protein alpha-subunit binding |
| MF | IBA | GO:0004930 | G-protein coupled receptor activity |
| MF | IEA | GO:0004930 | G-protein coupled receptor activity |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| BP | IEA | GO:0007166 | cell surface receptor signaling pathway |
| BP | IEA | GO:0007186 | G-protein coupled receptor signaling pathway |
Gene expression in normal tissue: ADGRG4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ADGRG4
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD144 | NSC95397 | 8 |
| iGMDRD484 | Pluripotin | 2 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD152 | 179324-69-7 | 6 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD297 | Austocystin D | 6 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD138 | PX 12 | 6 |
| iGMDRD255 | SB225002 | 6 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD226 | ML006 | 2 |
| iGMDRD885 | Compound 110 | 4 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD399 | Selumetinib | 5 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD299 | ICL 670 | 2 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD150 | RITA | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD698 | Neratinib | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 1 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD901 | ELCPK | 6 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD154 | NSC23766 | 2 |
| iGMDRD945 | ML214 | 8 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD434 | BMS-536924 | 5 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD882 | CIL41 | 2 |
| iGMDRD872 | BRD7137 | 8 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD871 | BRD6368 | 10 |
| iGMDRD552 | AZD-1775 | 3 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD300 | Tozasertib | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ADGRG4
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