ADGRG4


Summary: This gene encodes a G-protein coupled receptor belonging to a large family of diverse integral membrane proteins that participate in various physiological functions. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The ligand for this family member is unknown, and it is therefore an orphan receptor. This receptor is known to be expressed in normal enterochromaffin cells and in gastrointestinal neuroendocrine carcinoma cells, and it is therefore considered to be a novel biomarker or target for immunotherapy. [provided by RefSeq, May 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
adhesion G protein-coupled receptor G4Ensembl:ENSG00000156920HGNC:HGNC:18992PA134885132Xq26.3

GO terms in ADGRG4


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0001965G-protein alpha-subunit binding
MFIBAGO:0004930G-protein coupled receptor activity
MFIEAGO:0004930G-protein coupled receptor activity
CCIBAGO:0005887integral component of plasma membrane
CCIEAGO:0016021integral component of membrane
BPIEAGO:0007166cell surface receptor signaling pathway
BPIEAGO:0007186G-protein coupled receptor signaling pathway

Gene expression in normal tissue: ADGRG4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ADGRG4


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD126Tipifarnib3
iGMDRD420Leucascandrolide A3
iGMDRD670ML 2103
iGMDRD144NSC953978
iGMDRD484Pluripotin2
iGMDRD446LY 21832402
iGMDRD61Kinetin riboside2
iGMDRD152179324-69-76
iGMDRD466Chaetocin3
iGMDRD679Bistramide A2
iGMDRD280CYTOCHALASIN B2
iGMDRD297Austocystin D6
iGMDRD634SCHEMBL26080412
iGMDRD138PX 126
iGMDRD255SB2250026
iGMDRD782DC-45-A23
iGMDRD870BRD636103
iGMDRD226ML0062
iGMDRD885Compound 1104
iGMDRD318PAC-12
iGMDRD399Selumetinib5
iGMDRD188Piperlongumine2
iGMDRD398Sepantronium2
iGMDRD577BIX012942
iGMDRD888Compound 441
iGMDRD369TGX-1153
iGMDRD64Parbendazole3
iGMDRD84Lovastatin acid3
iGMDRD512nutlin 33
iGMDRD299ICL 6702
iGMDRD424Tamatinib3
iGMDRD150RITA3
iGMDRD523Cyanoquinoline, 113
iGMDRD341Triacsin c2
iGMDRD237ABT-7513
iGMDRD698Neratinib3
iGMDRD57Chloropentafluorobenzene1
iGMDRD351GW843682X2
iGMDRD314Tanespimycin3
iGMDRD123Isoevodiamine3
iGMDRD901ELCPK6
iGMDRD211(1S,3R)-RSL33
iGMDRD154NSC237662
iGMDRD945ML2148
iGMDRD202Curcumin3
iGMDRD137Indisulam2
iGMDRD251ML1623
iGMDRD5Tyrphostin AG 14783
iGMDRD434BMS-5369245
iGMDRD289Parthenolide3
iGMDRD213SMR0000686502
iGMDRD77Itraconazole3
iGMDRD882CIL412
iGMDRD872BRD71378
iGMDRD286Nsc 6328393
iGMDRD871BRD636810
iGMDRD552AZD-17753
iGMDRD246NPC262
iGMDRD300Tozasertib2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ADGRG4

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