FLI1


Summary: This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
Fli-1 proto-oncogene, ETS transcription factorMIM:193067Ensembl:ENSG00000151702HGNC:HGNC:3749PA2817011q24.3

GO terms in FLI1


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0006357regulation of transcription by RNA polymerase II
BPIEAGO:0006366transcription by RNA polymerase II
BPTASGO:0007599hemostasis
BPIEAGO:0008015blood circulation
BPIEAGO:0009887animal organ morphogenesis
BPIBAGO:0030154cell differentiation
BPIEAGO:0035855megakaryocyte development
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005829cytosol
CCIDAGO:0016604nuclear body
MFIEAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFIEAGO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding
MFIBAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFTASGO:0003677DNA binding
MFIEAGO:0003682chromatin binding
MFTASGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding

Gene expression in normal tissue: FLI1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FLI1


DatabasePathway IDPathway Des.
wikipathwaysWP2849Hematopoietic Stem Cell Differentiation
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD151CHM-13
iGMDRD144NSC953973
iGMDRD546BMS-7548071
iGMDRD446LY 21832402
iGMDRD193Fqi14
iGMDRD394BX-7952
iGMDRD280CYTOCHALASIN B2
iGMDRD679Bistramide A1
iGMDRD298L-6854583
iGMDRD260FQI-23
iGMDRD870BRD636103
iGMDRD887Compound 23 citrate3
iGMDRD506Fedratinib2
iGMDRD398Sepantronium3
iGMDRD780PP-302
iGMDRD562Navitoclax2
iGMDRD64Parbendazole3
iGMDRD60Quinoclamine2
iGMDRD23Gossypol3
iGMDRD307Manumycin A3
iGMDRD116CD4373
iGMDRD424Tamatinib3
iGMDRD523Cyanoquinoline, 113
iGMDRD701NVP-AUY9223
iGMDRD79Gemcitabine2
iGMDRD341Triacsin c2
iGMDRD698Neratinib3
iGMDRD219Bax channel blocker3
iGMDRD901ELCPK6
iGMDRD123Isoevodiamine3
iGMDRD883CIL55A3
iGMDRD103SN-383
iGMDRD121GMX17783
iGMDRD202Curcumin3
iGMDRD705Nakiterpiosin3
iGMDRD434BMS-5369247
iGMDRD267Oligomycin A2
iGMDRD414MST-3125
iGMDRD871BRD63683
iGMDRD286Nsc 6328393
iGMDRD872BRD71372
iGMDRD300Tozasertib3
iGMDRD886Compound 1541A3
iGMDRD505Pevonedistat6
iGMDRD263AACOCF32
iGMDRD322FK 8666

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FLI1

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