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FLI1

Summary: This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Fli-1 proto-oncogene, ETS transcription factor	MIM:193067	Ensembl:ENSG00000151702	HGNC:HGNC:3749	PA28170	11q24.3

GO terms in FLI1

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IBA	GO:0006357	regulation of transcription by RNA polymerase II
BP	IEA	GO:0006366	transcription by RNA polymerase II
BP	TAS	GO:0007599	hemostasis
BP	IEA	GO:0008015	blood circulation
BP	IEA	GO:0009887	animal organ morphogenesis
BP	IBA	GO:0030154	cell differentiation
BP	IEA	GO:0035855	megakaryocyte development
BP	IDA	GO:0045893	positive regulation of transcription, DNA-templated
BP	IEA	GO:0045944	positive regulation of transcription by RNA polymerase II
CC	IBA	GO:0005634	nucleus
CC	IDA	GO:0005634	nucleus
CC	IDA	GO:0005829	cytosol
CC	IDA	GO:0016604	nuclear body
MF	IEA	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
MF	IEA	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
MF	IBA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	ISA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	ISM	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	NAS	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	IEA	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MF	TAS	GO:0003677	DNA binding
MF	IEA	GO:0003682	chromatin binding
MF	TAS	GO:0003700	DNA-binding transcription factor activity
MF	IPI	GO:0005515	protein binding

Gene expression in normal tissue: FLI1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FLI1

Database	Pathway ID	Pathway Des.
wikipathways	WP2849	Hematopoietic Stem Cell Differentiation
kegg	hsa05202	Transcriptional misregulation in cancer - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD151	CHM-1	3
iGMDRD144	NSC95397	3
iGMDRD546	BMS-754807	1
iGMDRD446	LY 2183240	2
iGMDRD193	Fqi1	4
iGMDRD394	BX-795	2
iGMDRD280	CYTOCHALASIN B	2
iGMDRD679	Bistramide A	1
iGMDRD298	L-685458	3
iGMDRD260	FQI-2	3
iGMDRD870	BRD63610	3
iGMDRD887	Compound 23 citrate	3
iGMDRD506	Fedratinib	2
iGMDRD398	Sepantronium	3
iGMDRD780	PP-30	2
iGMDRD562	Navitoclax	2
iGMDRD64	Parbendazole	3
iGMDRD60	Quinoclamine	2
iGMDRD23	Gossypol	3
iGMDRD307	Manumycin A	3
iGMDRD116	CD437	3
iGMDRD424	Tamatinib	3
iGMDRD523	Cyanoquinoline, 11	3
iGMDRD701	NVP-AUY922	3
iGMDRD79	Gemcitabine	2
iGMDRD341	Triacsin c	2
iGMDRD698	Neratinib	3
iGMDRD219	Bax channel blocker	3
iGMDRD901	ELCPK	6
iGMDRD123	Isoevodiamine	3
iGMDRD883	CIL55A	3
iGMDRD103	SN-38	3
iGMDRD121	GMX1778	3
iGMDRD202	Curcumin	3
iGMDRD705	Nakiterpiosin	3
iGMDRD434	BMS-536924	7
iGMDRD267	Oligomycin A	2
iGMDRD414	MST-312	5
iGMDRD871	BRD6368	3
iGMDRD286	Nsc 632839	3
iGMDRD872	BRD7137	2
iGMDRD300	Tozasertib	3
iGMDRD886	Compound 1541A	3
iGMDRD505	Pevonedistat	6
iGMDRD263	AACOCF3	2
iGMDRD322	FK 866	6

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FLI1

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.