FGF4


Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
fibroblast growth factor 4MIM:164980Ensembl:ENSG00000075388HGNC:HGNC:3682PA2812111q13.3

GO terms in FGF4


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0004713protein tyrosine kinase activity
MFTASGO:0005088Ras guanyl-nucleotide exchange factor activity
MFIEAGO:0005104fibroblast growth factor receptor binding
MFIEAGO:0008083growth factor activity
MFIEAGO:0008201heparin binding
MFTASGO:00163031-phosphatidylinositol-3-kinase activity
MFTASGO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity
CCTASGO:0005576extracellular region
CCIEAGO:0005622intracellular
BPTASGO:0000165MAPK cascade
BPIEAGO:0001502cartilage condensation
BPTASGO:0007165signal transduction
BPTASGO:0007267cell-cell signaling
BPIGIGO:0008284positive regulation of cell proliferation
BPIGIGO:0008543fibroblast growth factor receptor signaling pathway
BPTASGO:0008543fibroblast growth factor receptor signaling pathway
BPIDAGO:0010463mesenchymal cell proliferation
BPIEAGO:0010469regulation of signaling receptor activity
BPIEAGO:0018108peptidyl-tyrosine phosphorylation
BPIEAGO:0019827stem cell population maintenance
BPIEAGO:0035116embryonic hindlimb morphogenesis
BPIEAGO:0036092phosphatidylinositol-3-phosphate biosynthetic process
BPIEAGO:0042475odontogenesis of dentin-containing tooth
BPIEAGO:0043066negative regulation of apoptotic process
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0046854phosphatidylinositol phosphorylation
BPIEAGO:0051781positive regulation of cell division
BPTASGO:0051897positive regulation of protein kinase B signaling
BPIEAGO:0060363cranial suture morphogenesis
BPIEAGO:0060561apoptotic process involved in morphogenesis
BPIDAGO:0060591chondroblast differentiation
BPIDAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIEAGO:1990830cellular response to leukemia inhibitory factor
BPIDAGO:2000544regulation of endothelial cell chemotaxis to fibroblast growth factor

Gene expression in normal tissue: FGF4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FGF4


DatabasePathway IDPathway Des.
reactomeR-HSA-109704PI3K Cascade
reactomeR-HSA-112399IRS-mediated signalling
reactomeR-HSA-1226099Signaling by FGFR in disease
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-1839122Signaling by activated point mutants of FGFR1
reactomeR-HSA-1839124FGFR1 mutant receptor activation
reactomeR-HSA-1839126FGFR2 mutant receptor activation
reactomeR-HSA-1839130Signaling by activated point mutants of FGFR3
reactomeR-HSA-190236Signaling by FGFR
reactomeR-HSA-190239FGFR3 ligand binding and activation
reactomeR-HSA-190241FGFR2 ligand binding and activation
reactomeR-HSA-190242FGFR1 ligand binding and activation
reactomeR-HSA-190322FGFR4 ligand binding and activation
reactomeR-HSA-190372FGFR3c ligand binding and activation
reactomeR-HSA-190373FGFR1c ligand binding and activation
reactomeR-HSA-190375FGFR2c ligand binding and activation
reactomeR-HSA-199418Negative regulation of the PI3K/AKT network
reactomeR-HSA-2033514FGFR3 mutant receptor activation
reactomeR-HSA-2033519Activated point mutants of FGFR2
reactomeR-HSA-2219528PI3K/AKT Signaling in Cancer
reactomeR-HSA-2219530Constitutive Signaling by Aberrant PI3K in Cancer
reactomeR-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
reactomeR-HSA-2428924IGF1R signaling cascade
reactomeR-HSA-2428928IRS-related events triggered by IGF1R
reactomeR-HSA-5654219Phospholipase C-mediated cascade: FGFR1
reactomeR-HSA-5654221Phospholipase C-mediated cascade; FGFR2
reactomeR-HSA-5654227Phospholipase C-mediated cascade; FGFR3
reactomeR-HSA-5654228Phospholipase C-mediated cascade; FGFR4
reactomeR-HSA-5654687Downstream signaling of activated FGFR1
reactomeR-HSA-5654688SHC-mediated cascade:FGFR1
reactomeR-HSA-5654689PI-3K cascade:FGFR1
reactomeR-HSA-5654693FRS-mediated FGFR1 signaling
reactomeR-HSA-5654695PI-3K cascade:FGFR2
reactomeR-HSA-5654696Downstream signaling of activated FGFR2
reactomeR-HSA-5654699SHC-mediated cascade:FGFR2
reactomeR-HSA-5654700FRS-mediated FGFR2 signaling
reactomeR-HSA-5654704SHC-mediated cascade:FGFR3
reactomeR-HSA-5654706FRS-mediated FGFR3 signaling
reactomeR-HSA-5654708Downstream signaling of activated FGFR3
reactomeR-HSA-5654710PI-3K cascade:FGFR3
reactomeR-HSA-5654712FRS-mediated FGFR4 signaling
reactomeR-HSA-5654716Downstream signaling of activated FGFR4
reactomeR-HSA-5654719SHC-mediated cascade:FGFR4
reactomeR-HSA-5654720PI-3K cascade:FGFR4
reactomeR-HSA-5654726Negative regulation of FGFR1 signaling
reactomeR-HSA-5654727Negative regulation of FGFR2 signaling
reactomeR-HSA-5654732Negative regulation of FGFR3 signaling
reactomeR-HSA-5654733Negative regulation of FGFR4 signaling
reactomeR-HSA-5654736Signaling by FGFR1
reactomeR-HSA-5654738Signaling by FGFR2
reactomeR-HSA-5654741Signaling by FGFR3
reactomeR-HSA-5654743Signaling by FGFR4
reactomeR-HSA-5655253Signaling by FGFR2 in disease
reactomeR-HSA-5655302Signaling by FGFR1 in disease
reactomeR-HSA-5655332Signaling by FGFR3 in disease
reactomeR-HSA-5658623FGFRL1 modulation of FGFR1 signaling
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
reactomeR-HSA-74751Insulin receptor signalling cascade
reactomeR-HSA-74752Signaling by Insulin receptor
reactomeR-HSA-8853338Signaling by FGFR3 point mutants in cancer
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
wikipathwaysWP2848Differentiation Pathway
wikipathwaysWP3584MECP2 and Associated Rett Syndrome
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP51Regulation of Actin Cytoskeleton
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05218Melanoma - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
pidajdiss_2pathwayPosttranslational regulation of adherens junction stability and dissassembly
pidbetacatenin_nuc_pathwayRegulation of nuclear beta catenin signaling and target gene transcription
pidfgf_pathwayFGF signaling pathway
pidsyndecan_1_pathwaySyndecan-1-mediated signaling events
pidsyndecan_2_pathwaySyndecan-2-mediated signaling events
pidsyndecan_3_pathwaySyndecan-3-mediated signaling events

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD634SCHEMBL26080412
iGMDRD211(1S,3R)-RSL32
iGMDRD314Tanespimycin2
iGMDRD61Kinetin riboside5
iGMDRD567E-38101
iGMDRD523Cyanoquinoline, 113
iGMDRD494Neopeltolide2
iGMDRD405PIK-752
iGMDRD424Tamatinib1
iGMDRD144NSC953972
iGMDRD126Tipifarnib1
iGMDRD307Manumycin A1
iGMDRD23Gossypol5
iGMDRD329Merck602
iGMDRD562Navitoclax8
iGMDRD871BRD63688
iGMDRD887Compound 23 citrate3
iGMDRD441TW 372
iGMDRD267Oligomycin A3
iGMDRD674Dovitinib2
iGMDRD255SB2250023
iGMDRD137Indisulam2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FGF4

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