GAS7
Summary: Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary in the N-terminus have been described. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| growth arrest specific 7 | MIM:603127 | Ensembl:ENSG00000007237 | HGNC:HGNC:4169 | PA28583 | 17p13.1 |
Gene Categories:
TUMOR SUPPRESSORGO terms in GAS7
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IBA | GO:0007010 | cytoskeleton organization |
| BP | TAS | GO:0007050 | cell cycle arrest |
| BP | IEA | GO:0007399 | nervous system development |
| BP | IBA | GO:0030041 | actin filament polymerization |
| BP | IEA | GO:0030154 | cell differentiation |
| BP | IBA | GO:0030182 | neuron differentiation |
| BP | IBA | GO:0048812 | neuron projection morphogenesis |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005856 | cytoskeleton |
| CC | IBA | GO:0005884 | actin filament |
| CC | IBA | GO:0005886 | plasma membrane |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008092 | cytoskeletal protein binding |
| MF | IBA | GO:0051015 | actin filament binding |
Gene expression in normal tissue: GAS7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GAS7
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD60 | Quinoclamine | 1 |
| iGMDRD552 | AZD-1775 | 3 |
| iGMDRD505 | Pevonedistat | 6 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD562 | Navitoclax | 4 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD481 | Dactolisib | 2 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD202 | Curcumin | 4 |
| iGMDRD103 | SN-38 | 2 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 4 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD698 | Neratinib | 2 |
| iGMDRD314 | Tanespimycin | 2 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD483 | SCH-529074 | 1 |
| iGMDRD523 | Cyanoquinoline, 11 | 2 |
| iGMDRD427 | ABT737 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GAS7
CLASSFICATION
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