GAS7
Summary: Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary in the N-terminus have been described. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
growth arrest specific 7 | MIM:603127 | Ensembl:ENSG00000007237 | HGNC:HGNC:4169 | PA28583 | 17p13.1 |
Gene Categories:
TUMOR SUPPRESSORGO terms in GAS7
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
BP | IBA | GO:0007010 | cytoskeleton organization |
BP | TAS | GO:0007050 | cell cycle arrest |
BP | IEA | GO:0007399 | nervous system development |
BP | IBA | GO:0030041 | actin filament polymerization |
BP | IEA | GO:0030154 | cell differentiation |
BP | IBA | GO:0030182 | neuron differentiation |
BP | IBA | GO:0048812 | neuron projection morphogenesis |
CC | IBA | GO:0005737 | cytoplasm |
CC | IEA | GO:0005737 | cytoplasm |
CC | IBA | GO:0005856 | cytoskeleton |
CC | IBA | GO:0005884 | actin filament |
CC | IBA | GO:0005886 | plasma membrane |
MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
MF | IPI | GO:0005515 | protein binding |
MF | IBA | GO:0008092 | cytoskeletal protein binding |
MF | IBA | GO:0051015 | actin filament binding |
Gene expression in normal tissue: GAS7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GAS7
Database | Pathway ID | Pathway Des. |
---|
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD60 | Quinoclamine | 1 |
iGMDRD552 | AZD-1775 | 3 |
iGMDRD505 | Pevonedistat | 6 |
iGMDRD780 | PP-30 | 3 |
iGMDRD562 | Navitoclax | 4 |
iGMDRD77 | Itraconazole | 2 |
iGMDRD267 | Oligomycin A | 2 |
iGMDRD318 | PAC-1 | 1 |
iGMDRD481 | Dactolisib | 2 |
iGMDRD434 | BMS-536924 | 2 |
iGMDRD782 | DC-45-A2 | 2 |
iGMDRD705 | Nakiterpiosin | 2 |
iGMDRD121 | GMX1778 | 2 |
iGMDRD202 | Curcumin | 4 |
iGMDRD103 | SN-38 | 2 |
iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
iGMDRD394 | BX-795 | 2 |
iGMDRD280 | CYTOCHALASIN B | 4 |
iGMDRD901 | ELCPK | 2 |
iGMDRD698 | Neratinib | 2 |
iGMDRD314 | Tanespimycin | 2 |
iGMDRD85 | Ursolic acid | 3 |
iGMDRD446 | LY 2183240 | 3 |
iGMDRD494 | Neopeltolide | 2 |
iGMDRD483 | SCH-529074 | 1 |
iGMDRD523 | Cyanoquinoline, 11 | 2 |
iGMDRD427 | ABT737 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GAS7