TRPM6
Summary: This gene is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. It is crucial for magnesium homeostasis, and plays an essential role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Mutations in this gene are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Apr 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| transient receptor potential cation channel subfamily M member 6 | MIM:607009 | Ensembl:ENSG00000119121 | HGNC:HGNC:17995 | PA38479 | 9q21.13 |
GO terms in TRPM6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0005262 | calcium channel activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0009636 | response to toxic substance |
| BP | IEA | GO:0051262 | protein tetramerization |
| BP | TAS | GO:0070588 | calcium ion transmembrane transport |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0016324 | apical plasma membrane |
| CC | IEA | GO:0031526 | brush border membrane |
Gene expression in normal tissue: TRPM6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TRPM6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-2672351 | Stimuli-sensing channels |
| reactome | R-HSA-3295583 | TRP channels |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-983712 | Ion channel transport |
| kegg | hsa04978 | Mineral absorption - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 5 |
| iGMDRD394 | BX-795 | 4 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD126 | Tipifarnib | 6 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD405 | PIK-75 | 1 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD662 | JQ-1 | 1 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD286 | Nsc 632839 | 6 |
| iGMDRD42 | Vorinostat | 2 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD147 | Prima-1 | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD158 | NSC141540 | 4 |
| iGMDRD271 | Brefeldin A | 1 |
| iGMDRD415 | LE-135 | 3 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD870 | BRD63610 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TRPM6
CLASSFICATION
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