RIOK1
Summary: The protein encoded by this gene competes with pICln for inclusion in the protein arginine methyltransferase 5 complex. This complex targets substrates for dimethylation. The encoded protein is essential for the last steps in the maturation of 40S subunits. [provided by RefSeq, Jan 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| RIO kinase 1 | MIM:617753 | Ensembl:ENSG00000124784 | HGNC:HGNC:18656 | PA134928236 | 6p24.3 |
GO terms in RIOK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0016787 | hydrolase activity |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0030490 | maturation of SSU-rRNA |
| BP | IMP | GO:0030490 | maturation of SSU-rRNA |
| BP | IMP | GO:0042274 | ribosomal small subunit biogenesis |
| BP | IMP | GO:2000234 | positive regulation of rRNA processing |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0030688 | preribosome, small subunit precursor |
| CC | IDA | GO:0030688 | preribosome, small subunit precursor |
| CC | IMP | GO:0034708 | methyltransferase complex |
Gene expression in normal tissue: RIOK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RIOK1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol |
| reactome | R-HSA-72312 | rRNA processing |
| reactome | R-HSA-8868773 | rRNA processing in the nucleus and cytosol |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| kegg | hsa03008 | Ribosome biogenesis in eukaryotes - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD435 | BI-2536 | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 2 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD599 | Salermide | 2 |
| iGMDRD248 | BRD4354 | 2 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD554 | CHEMBL1434137 | 2 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD330 | BRD4132 | 4 |
| iGMDRD23 | Gossypol | 6 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD888 | Compound 44 | 4 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD202 | Curcumin | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RIOK1
CLASSFICATION
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