RIOK1


Summary: The protein encoded by this gene competes with pICln for inclusion in the protein arginine methyltransferase 5 complex. This complex targets substrates for dimethylation. The encoded protein is essential for the last steps in the maturation of 40S subunits. [provided by RefSeq, Jan 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
RIO kinase 1MIM:617753Ensembl:ENSG00000124784HGNC:HGNC:18656PA1349282366p24.3

GO terms in RIOK1


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIEAGO:0016787hydrolase activity
MFIEAGO:0046872metal ion binding
BPIEAGO:0006468protein phosphorylation
BPIBAGO:0030490maturation of SSU-rRNA
BPIMPGO:0030490maturation of SSU-rRNA
BPIMPGO:0042274ribosomal small subunit biogenesis
BPIMPGO:2000234positive regulation of rRNA processing
CCTASGO:0005654nucleoplasm
CCIBAGO:0005829cytosol
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIBAGO:0030688preribosome, small subunit precursor
CCIDAGO:0030688preribosome, small subunit precursor
CCIMPGO:0034708methyltransferase complex

Gene expression in normal tissue: RIOK1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RIOK1


DatabasePathway IDPathway Des.
reactomeR-HSA-6791226Major pathway of rRNA processing in the nucleolus and cytosol
reactomeR-HSA-72312rRNA processing
reactomeR-HSA-8868773rRNA processing in the nucleus and cytosol
reactomeR-HSA-8953854Metabolism of RNA
kegghsa03008Ribosome biogenesis in eukaryotes - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD435BI-25363
iGMDRD123Isoevodiamine3
iGMDRD523Cyanoquinoline, 112
iGMDRD494Neopeltolide3
iGMDRD79Gemcitabine1
iGMDRD599Salermide2
iGMDRD248BRD43542
iGMDRD420Leucascandrolide A3
iGMDRD554CHEMBL14341372
iGMDRD151CHM-13
iGMDRD330BRD41324
iGMDRD23Gossypol6
iGMDRD82Quiflapon2
iGMDRD300Tozasertib2
iGMDRD577BIX012943
iGMDRD506Fedratinib3
iGMDRD888Compound 444
iGMDRD562Navitoclax6
iGMDRD100Zebularine2
iGMDRD871BRD63682
iGMDRD187BRD98761
iGMDRD52Rotenone3
iGMDRD267Oligomycin A3
iGMDRD705Nakiterpiosin3
iGMDRD513BML-2591
iGMDRD137Indisulam3
iGMDRD202Curcumin3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RIOK1

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