PAWR


Summary: This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases. [provided by RefSeq, Aug 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
pro-apoptotic WT1 regulatorMIM:601936Ensembl:ENSG00000177425HGNC:HGNC:8614PA3295412q21.2

GO terms in PAWR


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0000790nuclear chromatin
CCIDAGO:0005634nucleus
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCIBAGO:0005884actin filament
CCISSGO:0005884actin filament
BPIEAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0006351transcription, DNA-templated
BPISSGO:0006915apoptotic process
BPIEAGO:0010628positive regulation of gene expression
BPIEAGO:0030889negative regulation of B cell proliferation
BPIEAGO:0042094interleukin-2 biosynthetic process
BPIEAGO:0042130negative regulation of T cell proliferation
BPIEAGO:0042986positive regulation of amyloid precursor protein biosynthetic process
BPIBAGO:0043065positive regulation of apoptotic process
BPNASGO:0043065positive regulation of apoptotic process
BPIEAGO:0048147negative regulation of fibroblast proliferation
BPIEAGO:0050860negative regulation of T cell receptor signaling pathway
BPISSGO:0051017actin filament bundle assembly
BPIEAGO:0097190apoptotic signaling pathway
BPIEAGO:1901300positive regulation of hydrogen peroxide-mediated programmed cell death
BPIEAGO:2000774positive regulation of cellular senescence
MFTASGO:0003714transcription corepressor activity
MFISSGO:0003779actin binding
MFIPIGO:0005515protein binding
MFIDAGO:0019899enzyme binding
MFIPIGO:0043522leucine zipper domain binding

Gene expression in normal tissue: PAWR

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PAWR


DatabasePathway IDPathway Des.
pidar_pathwayCoregulation of Androgen receptor activity
pidceramide_pathwayCeramide signaling pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD375GW-4058333
iGMDRD219Bax channel blocker3
iGMDRD701NVP-AUY9223
iGMDRD523Cyanoquinoline, 113
iGMDRD494Neopeltolide3
iGMDRD579PF7501
iGMDRD1008SR-II-138A3
iGMDRD584VER 1550081
iGMDRD60Quinoclamine3
iGMDRD398Sepantronium3
iGMDRD780PP-303
iGMDRD887Compound 23 citrate3
iGMDRD871BRD63681
iGMDRD77Itraconazole3
iGMDRD481Dactolisib1
iGMDRD434BMS-5369244

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PAWR

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