PAWR
Summary: This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases. [provided by RefSeq, Aug 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| pro-apoptotic WT1 regulator | MIM:601936 | Ensembl:ENSG00000177425 | HGNC:HGNC:8614 | PA32954 | 12q21.2 |
GO terms in PAWR
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005884 | actin filament |
| CC | ISS | GO:0005884 | actin filament |
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | ISS | GO:0006915 | apoptotic process |
| BP | IEA | GO:0010628 | positive regulation of gene expression |
| BP | IEA | GO:0030889 | negative regulation of B cell proliferation |
| BP | IEA | GO:0042094 | interleukin-2 biosynthetic process |
| BP | IEA | GO:0042130 | negative regulation of T cell proliferation |
| BP | IEA | GO:0042986 | positive regulation of amyloid precursor protein biosynthetic process |
| BP | IBA | GO:0043065 | positive regulation of apoptotic process |
| BP | NAS | GO:0043065 | positive regulation of apoptotic process |
| BP | IEA | GO:0048147 | negative regulation of fibroblast proliferation |
| BP | IEA | GO:0050860 | negative regulation of T cell receptor signaling pathway |
| BP | ISS | GO:0051017 | actin filament bundle assembly |
| BP | IEA | GO:0097190 | apoptotic signaling pathway |
| BP | IEA | GO:1901300 | positive regulation of hydrogen peroxide-mediated programmed cell death |
| BP | IEA | GO:2000774 | positive regulation of cellular senescence |
| MF | TAS | GO:0003714 | transcription corepressor activity |
| MF | ISS | GO:0003779 | actin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0019899 | enzyme binding |
| MF | IPI | GO:0043522 | leucine zipper domain binding |
Gene expression in normal tissue: PAWR
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PAWR
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | ar_pathway | Coregulation of Androgen receptor activity |
| pid | ceramide_pathway | Ceramide signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD219 | Bax channel blocker | 3 |
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD579 | PF750 | 1 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD584 | VER 155008 | 1 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD871 | BRD6368 | 1 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD434 | BMS-536924 | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PAWR
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