CSK
Summary: The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| C-terminal Src kinase | MIM:124095 | Ensembl:ENSG00000103653 | HGNC:HGNC:2444 | PA26946 | 15q24.1 |
GO terms in CSK
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0001817 | regulation of cytokine production |
| BP | IEA | GO:0002250 | adaptive immune response |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| BP | IEA | GO:0007420 | brain development |
| BP | IEA | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0010989 | negative regulation of low-density lipoprotein particle clearance |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | TAS | GO:0031295 | T cell costimulation |
| BP | IEA | GO:0032715 | negative regulation of interleukin-6 production |
| BP | IEA | GO:0033673 | negative regulation of kinase activity |
| BP | IBA | GO:0034332 | adherens junction organization |
| BP | IBA | GO:0038083 | peptidyl-tyrosine autophosphorylation |
| BP | IBA | GO:0042127 | regulation of cell proliferation |
| BP | IDA | GO:0042997 | negative regulation of Golgi to plasma membrane protein transport |
| BP | IEA | GO:0043406 | positive regulation of MAP kinase activity |
| BP | IBA | GO:0045087 | innate immune response |
| BP | IEA | GO:0045779 | negative regulation of bone resorption |
| BP | IEA | GO:0048709 | oligodendrocyte differentiation |
| BP | IEA | GO:0050765 | negative regulation of phagocytosis |
| BP | TAS | GO:0050852 | T cell receptor signaling pathway |
| BP | IBA | GO:0060368 | regulation of Fc receptor mediated stimulatory signaling pathway |
| BP | IEA | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| BP | IEA | GO:0071375 | cellular response to peptide hormone stimulus |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IPI | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005911 | cell-cell junction |
| CC | IBA | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane |
| CC | IEA | GO:0045121 | membrane raft |
| CC | HDA | GO:0070062 | extracellular exosome |
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | IBA | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | TAS | GO:0008022 | protein C-terminus binding |
| MF | TAS | GO:0016301 | kinase activity |
| MF | IEA | GO:0019903 | protein phosphatase binding |
| MF | IPI | GO:0034236 | protein kinase A catalytic subunit binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IEA | GO:0070064 | proline-rich region binding |
Gene expression in normal tissue: CSK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CSK
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP2512 | Integrated Lung Cancer Pathway |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| pid | bcr_5pathway | BCR signaling pathway |
| pid | cd8tcrpathway | TCR signaling in naïve CD8+ T cells |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | ptp1bpathway | Signaling events mediated by PTP1B |
| pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
| pharmgkb | PA2032 | VEGF Signaling Pathway |
| netpath | Pathway_EGFR1 | EGFR1 |
| kegg | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) |
| biocarta | cell2cellpathway | cell to cell adhesion signaling |
| biocarta | cskpathway | activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor |
| biocarta | ecmpathway | erk and pi-3 kinase are necessary for collagen binding in corneal epithelia |
| biocarta | integrinpathway | integrin signaling pathway |
| biocarta | vegfpathway | vegf hypoxia and angiogenesis |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-177929 | Signaling by EGFR |
| reactome | R-HSA-180292 | GAB1 signalosome |
| reactome | R-HSA-202403 | TCR signaling |
| reactome | R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains |
| reactome | R-HSA-354192 | Integrin alphaIIb beta3 signaling |
| reactome | R-HSA-388841 | Costimulation by the CD28 family |
| reactome | R-HSA-389948 | PD-1 signaling |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5674135 | MAP2K and MAPK activation |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants |
| reactome | R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants |
| reactome | R-HSA-6802949 | Signaling by RAS mutants |
| reactome | R-HSA-6802952 | Signaling by BRAF and RAF fusions |
| reactome | R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| reactome | R-HSA-6802957 | Oncogenic MAPK signaling |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76009 | Platelet Aggregation (Plug Formation) |
| reactome | R-HSA-9006921 | Integrin signaling |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD872 | BRD7137 | 4 |
| iGMDRD399 | Selumetinib | 6 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD524 | ISX-9 | 6 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD300 | Tozasertib | 5 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD318 | PAC-1 | 4 |
| iGMDRD226 | ML006 | 3 |
| iGMDRD885 | Compound 110 | 6 |
| iGMDRD481 | Dactolisib | 4 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD219 | Bax channel blocker | 2 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD148 | Pifithrin-mu | 2 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD126 | Tipifarnib | 7 |
| iGMDRD781 | Sirolimus | 8 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD546 | BMS-754807 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CSK
CLASSFICATION
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