EIF2AK1
Summary: The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| eukaryotic translation initiation factor 2 alpha kinase 1 | MIM:613635 | Ensembl:ENSG00000086232 | HGNC:HGNC:24921 | PA134919097 | 7p22.1 |
GO terms in EIF2AK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0002526 | acute inflammatory response |
| BP | IEA | GO:0006909 | phagocytosis |
| BP | IEA | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0010998 | regulation of translational initiation by eIF2 alpha phosphorylation |
| BP | IEA | GO:0010999 | regulation of eIF2 alpha phosphorylation by heme |
| BP | IEA | GO:0030225 | macrophage differentiation |
| BP | NAS | GO:0045993 | negative regulation of translational initiation by iron |
| BP | IEA | GO:0046501 | protoporphyrinogen IX metabolic process |
| BP | ISS | GO:0046777 | protein autophosphorylation |
| BP | ISS | GO:0046986 | negative regulation of hemoglobin biosynthetic process |
| BP | IEA | GO:0055072 | iron ion homeostasis |
| BP | IDA | GO:1990641 | response to iron ion starvation |
| CC | IEA | GO:0005737 | cytoplasm |
| MF | IBA | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity |
| MF | IDA | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | ISS | GO:0020037 | heme binding |
| MF | ISS | GO:0042803 | protein homodimerization activity |
Gene expression in normal tissue: EIF2AK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EIF2AK1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP107 | Translation Factors |
| kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| biocarta | eif2pathway | regulation of eif2 |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD394 | BX-795 | 2 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD484 | Pluripotin | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 1 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD289 | Parthenolide | 5 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EIF2AK1
CLASSFICATION
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