EIF2AK1
Summary: The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:613635 Ensembl IDEnsembl:ENSG00000086232 HGNC IDHGNC:HGNC:24921 PHARMGKB IDPA134919097 Map Location7p22.1 | |||||
GO terms in EIF2AK1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0002526 | acute inflammatory response |
| BP | IEA | GO:0006909 | phagocytosis |
| BP | IEA | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0010998 | regulation of translational initiation by eIF2 alpha phosphorylation |
| BP | IEA | GO:0010999 | regulation of eIF2 alpha phosphorylation by heme |
| BP | IEA | GO:0030225 | macrophage differentiation |
Gene expression in normal tissue: EIF2AK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EIF2AK1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP107 | Translation Factors |
| kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EIF2AK1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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