MAP3K13

Summary: The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namemitogen-activated protein kinase kinase kinase 13
OMIM IDMIM:604915
Ensembl IDEnsembl:ENSG00000073803
HGNC IDHGNC:HGNC:6852
PHARMGKB IDPA30596
Map Location3q27.2

GO terms in MAP3K13


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IBA GO:0000165 MAPK cascade
BP IDA GO:0000186 activation of MAPKK activity
BP IDA GO:0006468 protein phosphorylation
BP IBA GO:0007254 JNK cascade
BP IDA GO:0007254 JNK cascade
BP IBA GO:0007257 activation of JUN kinase activity
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Gene expression in normal tissue: MAP3K13

Gene-model tissue-cancer distribution: Bubble Plot

BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 18LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 15undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 59undefinedtissue: undefined cancer: NON_SMALL_CELL_CARCINOMA model num: 9

Gene-drug pathway distribution

undefined35DNA replication2Protein stability and degradation1Ferroptosis1Mitosis1Proteasome1IGFR signaling1Chromatin other1

Pathways in MAP3K13


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Database
Pathway ID
Pathway Des.
kegg hsa04010 MAPK signaling pathway - Homo sapiens (human)
wikipathways WP382 MAPK Signaling Pathway
wikipathways WP3915 Angiopoietin Like Protein 8 Regulatory Pathway
wikipathways WP481 Insulin Signaling
biocarta mapkpathway mapkinase signaling pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD356 PNU-74654 1
iGMDRD369 TGX-115 2
iGMDRD60 Quinoclamine 2
iGMDRD640 CAY10618 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAP3K13

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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