MAP3K13


Summary: The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
mitogen-activated protein kinase kinase kinase 13MIM:604915Ensembl:ENSG00000073803HGNC:HGNC:6852PA305963q27.2

GO terms in MAP3K13


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0000165MAPK cascade
BPIDAGO:0000186activation of MAPKK activity
BPIDAGO:0006468protein phosphorylation
BPIBAGO:0007254JNK cascade
BPIDAGO:0007254JNK cascade
BPIBAGO:0007257activation of JUN kinase activity
BPIDAGO:0046777protein autophosphorylation
BPIBAGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIDAGO:0051092positive regulation of NF-kappaB transcription factor activity
CCIBAGO:0008385IkappaB kinase complex
CCIDAGO:0008385IkappaB kinase complex
CCIDAGO:0016020membrane
MFIBAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004706JUN kinase kinase kinase activity
MFIBAGO:0004709MAP kinase kinase kinase activity
MFIDAGO:0004709MAP kinase kinase kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFISSGO:0019901protein kinase binding
MFIPIGO:0042802identical protein binding
MFIDAGO:0042803protein homodimerization activity
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: MAP3K13

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAP3K13


DatabasePathway IDPathway Des.
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP481Insulin Signaling
biocartamapkpathwaymapkinase signaling pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD356PNU-746541
iGMDRD369TGX-1152
iGMDRD60Quinoclamine2
iGMDRD640CAY106182
iGMDRD577BIX012945
iGMDRD887Compound 23 citrate1
iGMDRD885Compound 1101
iGMDRD679Bistramide A1
iGMDRD152179324-69-73
iGMDRD193Fqi12
iGMDRD61Kinetin riboside3
iGMDRD797ISOX DUAL3
iGMDRD446LY 21832402
iGMDRD546BMS-7548072
iGMDRD670ML 2102
iGMDRD144NSC953975
iGMDRD889Compound 7d-cis3
iGMDRD599Salermide3
iGMDRD554CHEMBL14341372
iGMDRD126Tipifarnib1
iGMDRD263AACOCF33
iGMDRD300Tozasertib5
iGMDRD329Merck603
iGMDRD662JQ-12
iGMDRD872BRD71372
iGMDRD414MST-3123
iGMDRD871BRD63686
iGMDRD231Importazole3
iGMDRD6AM-5802
iGMDRD705Nakiterpiosin1
iGMDRD158NSC1415403
iGMDRD103SN-383
iGMDRD901ELCPK2
iGMDRD211(1S,3R)-RSL32
iGMDRD237ABT-7513
iGMDRD314Tanespimycin2
iGMDRD341Triacsin c1
iGMDRD523Cyanoquinoline, 111
iGMDRD522ML-0301
iGMDRD148Pifithrin-mu1
iGMDRD330BRD41322
iGMDRD307Manumycin A2
iGMDRD84Lovastatin acid2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAP3K13

​​​​