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MAP3K13

Summary: The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
mitogen-activated protein kinase kinase kinase 13	MIM:604915	Ensembl:ENSG00000073803	HGNC:HGNC:6852	PA30596	3q27.2

Gene Categories:

DRUGGABLE GENOME CLINICALLY ACTIONABLE SERINE THREONINE KINASE KINASE

GO terms in MAP3K13

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IBA	GO:0000165	MAPK cascade
BP	IDA	GO:0000186	activation of MAPKK activity
BP	IDA	GO:0006468	protein phosphorylation
BP	IBA	GO:0007254	JNK cascade
BP	IDA	GO:0007254	JNK cascade
BP	IBA	GO:0007257	activation of JUN kinase activity
BP	IDA	GO:0046777	protein autophosphorylation
BP	IBA	GO:0051092	positive regulation of NF-kappaB transcription factor activity
BP	IDA	GO:0051092	positive regulation of NF-kappaB transcription factor activity
CC	IBA	GO:0008385	IkappaB kinase complex
CC	IDA	GO:0008385	IkappaB kinase complex
CC	IDA	GO:0016020	membrane
MF	IBA	GO:0004674	protein serine/threonine kinase activity
MF	IDA	GO:0004674	protein serine/threonine kinase activity
MF	IBA	GO:0004706	JUN kinase kinase kinase activity
MF	IBA	GO:0004709	MAP kinase kinase kinase activity
MF	IDA	GO:0004709	MAP kinase kinase kinase activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005524	ATP binding
MF	ISS	GO:0019901	protein kinase binding
MF	IPI	GO:0042802	identical protein binding
MF	IDA	GO:0042803	protein homodimerization activity
MF	IEA	GO:0046872	metal ion binding

Gene expression in normal tissue: MAP3K13

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAP3K13

Database	Pathway ID	Pathway Des.
kegg	hsa04010	MAPK signaling pathway - Homo sapiens (human)
wikipathways	WP382	MAPK Signaling Pathway
wikipathways	WP3915	Angiopoietin Like Protein 8 Regulatory Pathway
wikipathways	WP481	Insulin Signaling
biocarta	mapkpathway	mapkinase signaling pathway

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD356	PNU-74654	1
iGMDRD369	TGX-115	2
iGMDRD60	Quinoclamine	2
iGMDRD640	CAY10618	2
iGMDRD577	BIX01294	5
iGMDRD887	Compound 23 citrate	1
iGMDRD885	Compound 110	1
iGMDRD679	Bistramide A	1
iGMDRD152	179324-69-7	3
iGMDRD193	Fqi1	2
iGMDRD61	Kinetin riboside	3
iGMDRD797	ISOX DUAL	3
iGMDRD446	LY 2183240	2
iGMDRD546	BMS-754807	2
iGMDRD670	ML 210	2
iGMDRD144	NSC95397	5
iGMDRD889	Compound 7d-cis	3
iGMDRD599	Salermide	3
iGMDRD554	CHEMBL1434137	2
iGMDRD126	Tipifarnib	1
iGMDRD263	AACOCF3	3
iGMDRD300	Tozasertib	5
iGMDRD329	Merck60	3
iGMDRD662	JQ-1	2
iGMDRD872	BRD7137	2
iGMDRD414	MST-312	3
iGMDRD871	BRD6368	6
iGMDRD231	Importazole	3
iGMDRD6	AM-580	2
iGMDRD705	Nakiterpiosin	1
iGMDRD158	NSC141540	3
iGMDRD103	SN-38	3
iGMDRD901	ELCPK	2
iGMDRD211	(1S,3R)-RSL3	2
iGMDRD237	ABT-751	3
iGMDRD314	Tanespimycin	2
iGMDRD341	Triacsin c	1
iGMDRD523	Cyanoquinoline, 11	1
iGMDRD522	ML-030	1
iGMDRD148	Pifithrin-mu	1
iGMDRD330	BRD4132	2
iGMDRD307	Manumycin A	2
iGMDRD84	Lovastatin acid	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAP3K13

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DATATYPES

CLASSFICATION

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