CARS
Summary: This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cysteinyl-tRNA synthetase | MIM:123859 | Ensembl:ENSG00000110619 | HGNC:HGNC:1493 | PA26079 | 11p15.4 |
GO terms in CARS
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006418 | tRNA aminoacylation for protein translation |
| BP | IBA | GO:0006423 | cysteinyl-tRNA aminoacylation |
| BP | IDA | GO:0006423 | cysteinyl-tRNA aminoacylation |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| MF | IMP | GO:0000049 | tRNA binding |
| MF | NAS | GO:0000049 | tRNA binding |
| MF | IBA | GO:0004817 | cysteine-tRNA ligase activity |
| MF | IDA | GO:0004817 | cysteine-tRNA ligase activity |
| MF | TAS | GO:0004817 | cysteine-tRNA ligase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0005524 | ATP binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IMP | GO:0042803 | protein homodimerization activity |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: CARS
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CARS
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-379716 | Cytosolic tRNA aminoacylation |
| reactome | R-HSA-379724 | tRNA Aminoacylation |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-72766 | Translation |
| humancyc | TRNA-CHARGING-PWY | tRNA charging |
| kegg | hsa00970 | Aminoacyl-tRNA biosynthesis - Homo sapiens (human) |
| smpdb | SMP00013 | Cysteine Metabolism |
| smpdb | SMP00499 | Beta-mercaptolactate-cysteine disulfiduria |
| smpdb | SMP00722 | Cystinosis, ocular nonnephropathic |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD137 | Indisulam | 3 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD1008 | SR-II-138A | 6 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD123 | Isoevodiamine | 6 |
| iGMDRD280 | CYTOCHALASIN B | 9 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD351 | GW843682X | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CARS
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