CARS
Summary: This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2010].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:123859 Ensembl IDEnsembl:ENSG00000110619 HGNC IDHGNC:HGNC:1493 PHARMGKB IDPA26079 Map Location11p15.4 | |||||
GO terms in CARS
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006418 | tRNA aminoacylation for protein translation |
| BP | IBA | GO:0006423 | cysteinyl-tRNA aminoacylation |
| BP | IDA | GO:0006423 | cysteinyl-tRNA aminoacylation |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
Gene expression in normal tissue: CARS
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CARS
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-379716 | Cytosolic tRNA aminoacylation |
| reactome | R-HSA-379724 | tRNA Aminoacylation |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-72766 | Translation |
| humancyc | TRNA-CHARGING-PWY | tRNA charging |
| kegg | hsa00970 | Aminoacyl-tRNA biosynthesis - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CARS
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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