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EML4

Summary: This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants. [provided by RefSeq, Jan 2015].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
echinoderm microtubule associated protein like 4	MIM:607442	Ensembl:ENSG00000143924	HGNC:HGNC:1316	PA27769	2p21

GO terms in EML4

Term Type	Evidence Type	GO Term ID	GO Des.
CC	NAS	GO:0005737	cytoplasm
CC	IEA	GO:0005874	microtubule
CC	IBA	GO:0015630	microtubule cytoskeleton
CC	HDA	GO:0016020	membrane
BP	IBA	GO:0000226	microtubule cytoskeleton organization
BP	NAS	GO:0000278	mitotic cell cycle
BP	NAS	GO:0007017	microtubule-based process
MF	ND	GO:0003674	molecular_function
MF	IBA	GO:0008017	microtubule binding

Gene expression in normal tissue: EML4

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EML4

Database	Pathway ID	Pathway Des.
kegg	hsa05200	Pathways in cancer - Homo sapiens (human)
kegg	hsa05223	Non-small cell lung cancer - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD505	Pevonedistat	4
iGMDRD147	Prima-1	2
iGMDRD662	JQ-1	7
iGMDRD871	BRD6368	5
iGMDRD286	Nsc 632839	4
iGMDRD872	BRD7137	2
iGMDRD77	Itraconazole	3
iGMDRD267	Oligomycin A	2
iGMDRD289	Parthenolide	2
iGMDRD192	CIL56	2
iGMDRD5	Tyrphostin AG 1478	1
iGMDRD220	fumonisin B1	2
iGMDRD499	PDMP	1
iGMDRD314	Tanespimycin	5
iGMDRD85	Ursolic acid	1
iGMDRD523	Cyanoquinoline, 11	2
iGMDRD79	Gemcitabine	3
iGMDRD405	PIK-75	2
iGMDRD150	RITA	2
iGMDRD330	BRD4132	2
iGMDRD356	PNU-74654	1
iGMDRD268	Cerulenin	3
iGMDRD60	Quinoclamine	4
iGMDRD562	Navitoclax	3
iGMDRD188	Piperlongumine	4
iGMDRD318	PAC-1	2
iGMDRD187	BRD9876	2
iGMDRD52	Rotenone	4
iGMDRD466	Chaetocin	2
iGMDRD394	BX-795	2
iGMDRD201	SKI II	3
iGMDRD494	Neopeltolide	3
iGMDRD781	Sirolimus	1
iGMDRD144	NSC95397	2
iGMDRD599	Salermide	2
iGMDRD772	BRD4770	2
iGMDRD126	Tipifarnib	4

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EML4

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DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.