EML4


Summary: This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants. [provided by RefSeq, Jan 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
echinoderm microtubule associated protein like 4MIM:607442Ensembl:ENSG00000143924HGNC:HGNC:1316PA277692p21

GO terms in EML4


Term TypeEvidence TypeGO Term IDGO Des.
CCNASGO:0005737cytoplasm
CCIEAGO:0005874microtubule
CCIBAGO:0015630microtubule cytoskeleton
CCHDAGO:0016020membrane
BPIBAGO:0000226microtubule cytoskeleton organization
BPNASGO:0000278mitotic cell cycle
BPNASGO:0007017microtubule-based process
MFNDGO:0003674molecular_function
MFIBAGO:0008017microtubule binding

Gene expression in normal tissue: EML4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EML4


DatabasePathway IDPathway Des.
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD505Pevonedistat4
iGMDRD147Prima-12
iGMDRD662JQ-17
iGMDRD871BRD63685
iGMDRD286Nsc 6328394
iGMDRD872BRD71372
iGMDRD77Itraconazole3
iGMDRD267Oligomycin A2
iGMDRD289Parthenolide2
iGMDRD192CIL562
iGMDRD5Tyrphostin AG 14781
iGMDRD220fumonisin B12
iGMDRD499PDMP1
iGMDRD314Tanespimycin5
iGMDRD85Ursolic acid1
iGMDRD523Cyanoquinoline, 112
iGMDRD79Gemcitabine3
iGMDRD405PIK-752
iGMDRD150RITA2
iGMDRD330BRD41322
iGMDRD356PNU-746541
iGMDRD268Cerulenin3
iGMDRD60Quinoclamine4
iGMDRD562Navitoclax3
iGMDRD188Piperlongumine4
iGMDRD318PAC-12
iGMDRD187BRD98762
iGMDRD52Rotenone4
iGMDRD466Chaetocin2
iGMDRD394BX-7952
iGMDRD201SKI II3
iGMDRD494Neopeltolide3
iGMDRD781Sirolimus1
iGMDRD144NSC953972
iGMDRD599Salermide2
iGMDRD772BRD47702
iGMDRD126Tipifarnib4

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EML4

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