EML4
Summary: This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants. [provided by RefSeq, Jan 2015].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:607442 Ensembl IDEnsembl:ENSG00000143924 HGNC IDHGNC:HGNC:1316 PHARMGKB IDPA27769 Map Location2p21 | |||||
GO terms in EML4
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | NAS | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005874 | microtubule |
| CC | IBA | GO:0015630 | microtubule cytoskeleton |
| CC | HDA | GO:0016020 | membrane |
| BP | IBA | GO:0000226 | microtubule cytoskeleton organization |
| BP | NAS | GO:0000278 | mitotic cell cycle |
Gene expression in normal tissue: EML4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EML4
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EML4
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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