BCL3
Summary: This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| B cell CLL/lymphoma 3 | MIM:109560 | Ensembl:ENSG00000069399 | HGNC:HGNC:998 | PA25310 | 19q13.32 |
Gene Categories:
TRANSCRIPTION FACTOR BINDINGGO terms in BCL3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0000060 | protein import into nucleus, translocation |
| BP | IEA | GO:0002268 | follicular dendritic cell differentiation |
| BP | IEA | GO:0002315 | marginal zone B cell differentiation |
| BP | IEA | GO:0002455 | humoral immune response mediated by circulating immunoglobulin |
| BP | IEA | GO:0002467 | germinal center formation |
| BP | IDA | GO:0006351 | transcription, DNA-templated |
| BP | IDA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IDA | GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| BP | IDA | GO:0009615 | response to virus |
| BP | IDA | GO:0010225 | response to UV-C |
| BP | IEA | GO:0019730 | antimicrobial humoral response |
| BP | IEA | GO:0030198 | extracellular matrix organization |
| BP | IMP | GO:0030330 | DNA damage response, signal transduction by p53 class mediator |
| BP | IEA | GO:0032729 | positive regulation of interferon-gamma production |
| BP | IEA | GO:0042088 | T-helper 1 type immune response |
| BP | IEA | GO:0042536 | negative regulation of tumor necrosis factor biosynthetic process |
| BP | IEA | GO:0042742 | defense response to bacterium |
| BP | IMP | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| BP | IEA | GO:0042832 | defense response to protozoan |
| BP | IDA | GO:0042981 | regulation of apoptotic process |
| BP | IDA | GO:0043066 | negative regulation of apoptotic process |
| BP | IEA | GO:0045064 | T-helper 2 cell differentiation |
| BP | IEA | GO:0045082 | positive regulation of interleukin-10 biosynthetic process |
| BP | IMP | GO:0045415 | negative regulation of interleukin-8 biosynthetic process |
| BP | IMP | GO:0045727 | positive regulation of translation |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0046426 | negative regulation of JAK-STAT cascade |
| BP | IEA | GO:0048536 | spleen development |
| BP | IEP | GO:0051101 | regulation of DNA binding |
| BP | NAS | GO:0051457 | maintenance of protein location in nucleus |
| BP | IEP | GO:1901222 | regulation of NIK/NF-kappaB signaling |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0030496 | midbody |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IDA | GO:0032996 | Bcl3-Bcl10 complex |
| CC | IDA | GO:0033257 | Bcl3/NF-kappaB2 complex |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IEA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | TAS | GO:0030674 | protein binding, bridging |
Gene expression in normal tissue: BCL3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BCL3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2864 | Apoptosis-related network due to altered Notch3 in ovarian cancer |
| wikipathways | WP3611 | Photodynamic therapy-induced AP-1 survival signaling. |
| pid | nfkappabatypicalpathway | Atypical NF-kappaB pathway |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| netpath | Pathway_TNFalpha | TNFalpha |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD329 | Merck60 | 4 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD42 | Vorinostat | 2 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 1 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD289 | Parthenolide | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BCL3
CLASSFICATION
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