BCL3
Summary: This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:109560 Ensembl IDEnsembl:ENSG00000069399 HGNC IDHGNC:HGNC:998 PHARMGKB IDPA25310 Map Location19q13.32 | |||||
Gene Categories:
TRANSCRIPTION FACTOR BINDINGGO terms in BCL3
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0000060 | protein import into nucleus, translocation |
| BP | IEA | GO:0002268 | follicular dendritic cell differentiation |
| BP | IEA | GO:0002315 | marginal zone B cell differentiation |
| BP | IEA | GO:0002455 | humoral immune response mediated by circulating immunoglobulin |
| BP | IEA | GO:0002467 | germinal center formation |
| BP | IDA | GO:0006351 | transcription, DNA-templated |
Gene expression in normal tissue: BCL3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BCL3
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2864 | Apoptosis-related network due to altered Notch3 in ovarian cancer |
| wikipathways | WP3611 | Photodynamic therapy-induced AP-1 survival signaling. |
| pid | nfkappabatypicalpathway | Atypical NF-kappaB pathway |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| netpath | Pathway_TNFalpha | TNFalpha |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BCL3
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.