BCL3


Summary: This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
B cell CLL/lymphoma 3MIM:109560Ensembl:ENSG00000069399HGNC:HGNC:998PA2531019q13.32

GO terms in BCL3


Term TypeEvidence TypeGO Term IDGO Des.
BPIMPGO:0000060protein import into nucleus, translocation
BPIEAGO:0002268follicular dendritic cell differentiation
BPIEAGO:0002315marginal zone B cell differentiation
BPIEAGO:0002455humoral immune response mediated by circulating immunoglobulin
BPIEAGO:0002467germinal center formation
BPIDAGO:0006351transcription, DNA-templated
BPIDAGO:0006974cellular response to DNA damage stimulus
BPIDAGO:0007249I-kappaB kinase/NF-kappaB signaling
BPIDAGO:0009615response to virus
BPIDAGO:0010225response to UV-C
BPIEAGO:0019730antimicrobial humoral response
BPIEAGO:0030198extracellular matrix organization
BPIMPGO:0030330DNA damage response, signal transduction by p53 class mediator
BPIEAGO:0032729positive regulation of interferon-gamma production
BPIEAGO:0042088T-helper 1 type immune response
BPIEAGO:0042536negative regulation of tumor necrosis factor biosynthetic process
BPIEAGO:0042742defense response to bacterium
BPIMPGO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
BPIEAGO:0042832defense response to protozoan
BPIDAGO:0042981regulation of apoptotic process
BPIDAGO:0043066negative regulation of apoptotic process
BPIEAGO:0045064T-helper 2 cell differentiation
BPIEAGO:0045082positive regulation of interleukin-10 biosynthetic process
BPIMPGO:0045415negative regulation of interleukin-8 biosynthetic process
BPIMPGO:0045727positive regulation of translation
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0046426negative regulation of JAK-STAT cascade
BPIEAGO:0048536spleen development
BPIEPGO:0051101regulation of DNA binding
BPNASGO:0051457maintenance of protein location in nucleus
BPIEPGO:1901222regulation of NIK/NF-kappaB signaling
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCIDAGO:0030496midbody
CCIDAGO:0032991protein-containing complex
CCIDAGO:0032996Bcl3-Bcl10 complex
CCIDAGO:0033257Bcl3/NF-kappaB2 complex
CCIDAGO:0043231intracellular membrane-bounded organelle
CCIEAGO:0048471perinuclear region of cytoplasm
MFIEAGO:0003677DNA binding
MFIEAGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding
MFIPIGO:0008134transcription factor binding
MFTASGO:0030674protein binding, bridging

Gene expression in normal tissue: BCL3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BCL3


DatabasePathway IDPathway Des.
wikipathwaysWP2864Apoptosis-related network due to altered Notch3 in ovarian cancer
wikipathwaysWP3611Photodynamic therapy-induced AP-1 survival signaling.
pidnfkappabatypicalpathwayAtypical NF-kappaB pathway
kegghsa04625C-type lectin receptor signaling pathway - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
netpathPathway_TNFalphaTNFalpha

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD193Fqi13
iGMDRD329Merck604
iGMDRD506Fedratinib1
iGMDRD341Triacsin c2
iGMDRD23Gossypol3
iGMDRD42Vorinostat2
iGMDRD64Parbendazole3
iGMDRD297Austocystin D3
iGMDRD211(1S,3R)-RSL31
iGMDRD138PX 123
iGMDRD433Lexibulin3
iGMDRD330BRD41323
iGMDRD79Gemcitabine1
iGMDRD523Cyanoquinoline, 113
iGMDRD289Parthenolide3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BCL3

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