BCL3


Summary: This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:109560
PHARMGKB IDPA25310
Map Location19q13.32

GO terms in BCL3


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IMP GO:0000060 protein import into nucleus, translocation
BP IEA GO:0002268 follicular dendritic cell differentiation
BP IEA GO:0002315 marginal zone B cell differentiation
BP IEA GO:0002455 humoral immune response mediated by circulating immunoglobulin
BP IEA GO:0002467 germinal center formation
BP IDA GO:0006351 transcription, DNA-templated
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Gene expression in normal tissue: BCL3

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 17undefinedtissue: undefined cancer: ADENOCARCINOMA model num: 3undefinedtissue: undefined cancer: SMALL_CELL_CARCINOMA model num: 2BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 4LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 6OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 6

Gene-drug pathway distribution

undefined9Chromatin histone acetylation2Purine metabolism1Ferroptosis1Biosynthesis of secondary metabolites1Other, kinases1

Pathways in BCL3


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Database
Pathway ID
Pathway Des.
wikipathways WP2864 Apoptosis-related network due to altered Notch3 in ovarian cancer
wikipathways WP3611 Photodynamic therapy-induced AP-1 survival signaling.
pid nfkappabatypicalpathway Atypical NF-kappaB pathway
kegg hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
kegg hsa04668 TNF signaling pathway - Homo sapiens (human)
netpath Pathway_TNFalpha TNFalpha
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD193 Fqi1 3
iGMDRD329 Merck60 4
iGMDRD506 Fedratinib 1
iGMDRD341 Triacsin c 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BCL3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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