ITGA5
Summary: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| integrin subunit alpha 5 | MIM:135620 | Ensembl:ENSG00000161638 | HGNC:HGNC:6141 | PA29941 | 12q13.13 |
GO terms in ITGA5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0001726 | ruffle |
| CC | IEA | GO:0005783 | endoplasmic reticulum |
| CC | IEA | GO:0005794 | Golgi apparatus |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005911 | cell-cell junction |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0005925 | focal adhesion |
| CC | IEA | GO:0008305 | integrin complex |
| CC | IEA | GO:0009897 | external side of plasma membrane |
| CC | HDA | GO:0009986 | cell surface |
| CC | IDA | GO:0009986 | cell surface |
| CC | IEA | GO:0031410 | cytoplasmic vesicle |
| CC | IDA | GO:0032587 | ruffle membrane |
| CC | IEA | GO:0045202 | synapse |
| CC | TAS | GO:0071062 | alphav-beta3 integrin-vitronectin complex |
| BP | TAS | GO:0001525 | angiogenesis |
| BP | IEA | GO:0007044 | cell-substrate junction assembly |
| BP | TAS | GO:0007155 | cell adhesion |
| BP | IEA | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules |
| BP | IEA | GO:0007159 | leukocyte cell-cell adhesion |
| BP | IEA | GO:0007229 | integrin-mediated signaling pathway |
| BP | IEA | GO:0007613 | memory |
| BP | IEA | GO:0010811 | positive regulation of cell-substrate adhesion |
| BP | TAS | GO:0030198 | extracellular matrix organization |
| BP | IEA | GO:0030335 | positive regulation of cell migration |
| BP | TAS | GO:0030949 | positive regulation of vascular endothelial growth factor receptor signaling pathway |
| BP | IMP | GO:0031589 | cell-substrate adhesion |
| BP | IDA | GO:0033627 | cell adhesion mediated by integrin |
| BP | IEA | GO:0033631 | cell-cell adhesion mediated by integrin |
| BP | IMP | GO:0034113 | heterotypic cell-cell adhesion |
| BP | IEP | GO:0035313 | wound healing, spreading of epidermal cells |
| BP | IMP | GO:0035987 | endodermal cell differentiation |
| BP | IEA | GO:0046718 | viral entry into host cell |
| BP | IMP | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| BP | TAS | GO:0050900 | leukocyte migration |
| BP | IMP | GO:1903672 | positive regulation of sprouting angiogenesis |
| BP | IMP | GO:2000811 | negative regulation of anoikis |
| MF | IEA | GO:0001618 | virus receptor activity |
| MF | IEA | GO:0005154 | epidermal growth factor receptor binding |
| MF | TAS | GO:0005161 | platelet-derived growth factor receptor binding |
| MF | IEA | GO:0005178 | integrin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0043184 | vascular endothelial growth factor receptor 2 binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: ITGA5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ITGA5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1566948 | Elastic fibre formation |
| reactome | R-HSA-1566977 | Fibronectin matrix formation |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-216083 | Integrin cell surface interactions |
| reactome | R-HSA-216083 | Integrin cell surface interactions |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-445144 | Signal transduction by L1 |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878166 | Transcriptional regulation by RUNX2 |
| reactome | R-HSA-8941332 | RUNX2 regulates genes involved in cell migration |
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP2118 | Arrhythmogenic Right Ventricular Cardiomyopathy |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4180 | Ebola Virus Pathway on Host |
| wikipathways | WP4217 | Ebola Virus Pathway on Host |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| kegg | hsa04145 | Phagosome - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04512 | ECM-receptor interaction - Homo sapiens (human) |
| kegg | hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa05100 | Bacterial invasion of epithelial cells - Homo sapiens (human) |
| kegg | hsa05131 | Shigellosis - Homo sapiens (human) |
| kegg | hsa05133 | Pertussis - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05410 | Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human) |
| kegg | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human) |
| kegg | hsa05414 | Dilated cardiomyopathy (DCM) - Homo sapiens (human) |
| pid | angiopoietinreceptor_pathway | Angiopoietin receptor Tie2-mediated signaling |
| pid | arf6_traffickingpathway | Arf6 trafficking events |
| pid | fak_pathway | Signaling events mediated by focal adhesion kinase |
| pid | integrin1_pathway | Beta1 integrin cell surface interactions |
| pid | lymphangiogenesis_pathway | VEGFR3 signaling in lymphatic endothelium |
| pid | plexind1_pathway | Plexin-D1 Signaling |
| pid | syndecan_4_pathway | Syndecan-4-mediated signaling events |
| pid | upa_upar_pathway | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD60 | Quinoclamine | 8 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD945 | ML214 | 4 |
| iGMDRD341 | Triacsin c | 6 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD523 | Cyanoquinoline, 11 | 4 |
| iGMDRD267 | Oligomycin A | 4 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD889 | Compound 7d-cis | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ITGA5
CLASSFICATION
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