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ITGA5

Summary: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameintegrin subunit alpha 5 OMIM IDMIM:135620 Ensembl IDEnsembl:ENSG00000161638 HGNC IDHGNC:HGNC:6141 PHARMGKB IDPA29941 Map Location12q13.13

Gene Categories:

DRUGGABLE GENOME CELL SURFACE EXTERNAL SIDE OF PLASMA MEMBRANE

GO terms in ITGA5

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Term Type	Evidence Type	GO Term ID	GO Des.
CC	TAS	GO:0001726	ruffle
CC	IEA	GO:0005783	endoplasmic reticulum
CC	IEA	GO:0005794	Golgi apparatus
CC	TAS	GO:0005886	plasma membrane
CC	IDA	GO:0005911	cell-cell junction
CC	HDA	GO:0005925	focal adhesion

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Gene expression in normal tissue: ITGA5

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ITGA5

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-109582	Hemostasis
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-1474244	Extracellular matrix organization
reactome	R-HSA-1474244	Extracellular matrix organization
reactome	R-HSA-1566948	Elastic fibre formation
reactome	R-HSA-1566977	Fibronectin matrix formation

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD60	Quinoclamine	8
iGMDRD280	CYTOCHALASIN B	1
iGMDRD945	ML214	4
iGMDRD341	Triacsin c	6

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ITGA5

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.