TBX18
Summary: This genes codes for a member of an evolutionarily conserved family of transcription factors that plays a crucial role in embryonic development. The family is characterized by the presence of the DNA-binding T-box domain and is divided into five sub-families based on sequence conservation in this domain. The encoded protein belongs to the vertebrate specific Tbx1 sub-family. The protein acts as a transcriptional repressor by antagonizing transcriptional activators in the T-box family. The protein forms homo- or heterodimers with other transcription factors of the T-box family or other transcription factors. [provided by RefSeq, Nov 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| T-box 18 | MIM:604613 | Ensembl:ENSG00000112837 | HGNC:HGNC:11595 | PA36358 | 6q14.3 |
GO terms in TBX18
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0000976 | transcription regulatory region sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISS | GO:0003714 | transcription corepressor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0042803 | protein homodimerization activity |
| MF | ISS | GO:0046982 | protein heterodimerization activity |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0060829 | negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation |
| BP | IMP | GO:0072001 | renal system development |
| BP | IEA | GO:1903507 | negative regulation of nucleic acid-templated transcription |
| CC | IDA | GO:0005634 | nucleus |
| CC | ISS | GO:0005634 | nucleus |
Gene expression in normal tissue: TBX18
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TBX18
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD201 | SKI II | 3 |
| iGMDRD359 | OSW-1 | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD481 | Dactolisib | 3 |
| iGMDRD318 | PAC-1 | 5 |
| iGMDRD77 | Itraconazole | 6 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD329 | Merck60 | 6 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD872 | BRD7137 | 6 |
| iGMDRD42 | Vorinostat | 6 |
| iGMDRD524 | ISX-9 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TBX18
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.