TBX18


Summary: This genes codes for a member of an evolutionarily conserved family of transcription factors that plays a crucial role in embryonic development. The family is characterized by the presence of the DNA-binding T-box domain and is divided into five sub-families based on sequence conservation in this domain. The encoded protein belongs to the vertebrate specific Tbx1 sub-family. The protein acts as a transcriptional repressor by antagonizing transcriptional activators in the T-box family. The protein forms homo- or heterodimers with other transcription factors of the T-box family or other transcription factors. [provided by RefSeq, Nov 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
T-box 18MIM:604613Ensembl:ENSG00000112837HGNC:HGNC:11595PA363586q14.3

GO terms in TBX18


Term TypeEvidence TypeGO Term IDGO Des.
MFISSGO:0000976transcription regulatory region sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISSGO:0003714transcription corepressor activity
MFIPIGO:0005515protein binding
MFISSGO:0042803protein homodimerization activity
MFISSGO:0046982protein heterodimerization activity
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006357regulation of transcription by RNA polymerase II
BPISSGO:0060829negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation
BPIMPGO:0072001renal system development
BPIEAGO:1903507negative regulation of nucleic acid-templated transcription
CCIDAGO:0005634nucleus
CCISSGO:0005634nucleus

Gene expression in normal tissue: TBX18

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TBX18


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD1008SR-II-138A3
iGMDRD523Cyanoquinoline, 113
iGMDRD546BMS-7548073
iGMDRD427ABT7373
iGMDRD201SKI II3
iGMDRD359OSW-12
iGMDRD123Isoevodiamine3
iGMDRD394BX-7953
iGMDRD481Dactolisib3
iGMDRD318PAC-15
iGMDRD77Itraconazole6
iGMDRD434BMS-5369242
iGMDRD329Merck606
iGMDRD562Navitoclax2
iGMDRD871BRD63682
iGMDRD887Compound 23 citrate3
iGMDRD872BRD71376
iGMDRD42Vorinostat6
iGMDRD524ISX-93

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TBX18

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