MARK2
Summary: This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| microtubule affinity regulating kinase 2 | MIM:600526 | Ensembl:ENSG00000072518 | HGNC:HGNC:3332 | PA35047 | 11q13.1 |
GO terms in MARK2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000287 | magnesium ion binding |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | ISS | GO:0004674 | protein serine/threonine kinase activity |
| MF | NAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IEA | GO:0008289 | lipid binding |
| MF | TAS | GO:0030295 | protein kinase activator activity |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | ISS | GO:0048156 | tau protein binding |
| MF | IBA | GO:0050321 | tau-protein kinase activity |
| MF | IMP | GO:0050321 | tau-protein kinase activity |
| MF | ISS | GO:0050321 | tau-protein kinase activity |
| BP | IBA | GO:0000226 | microtubule cytoskeleton organization |
| BP | NAS | GO:0000422 | autophagy of mitochondrion |
| BP | ISS | GO:0001764 | neuron migration |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IMP | GO:0006468 | protein phosphorylation |
| BP | NAS | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0010976 | positive regulation of neuron projection development |
| BP | IEA | GO:0016055 | Wnt signaling pathway |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | ISS | GO:0018105 | peptidyl-serine phosphorylation |
| BP | TAS | GO:0018107 | peptidyl-threonine phosphorylation |
| BP | IDA | GO:0030010 | establishment of cell polarity |
| BP | TAS | GO:0030010 | establishment of cell polarity |
| BP | TAS | GO:0032147 | activation of protein kinase activity |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IDA | GO:0035556 | intracellular signal transduction |
| BP | IDA | GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity |
| BP | ISS | GO:0046777 | protein autophosphorylation |
| BP | IMP | GO:0050770 | regulation of axonogenesis |
| BP | ISS | GO:0051493 | regulation of cytoskeleton organization |
| BP | NAS | GO:0051646 | mitochondrion localization |
| BP | ISS | GO:0061564 | axon development |
| BP | IDA | GO:0070507 | regulation of microtubule cytoskeleton organization |
| BP | ISS | GO:0071963 | establishment or maintenance of cell polarity regulating cell shape |
| BP | ISS | GO:1904526 | regulation of microtubule binding |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | NAS | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005884 | actin filament |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IMP | GO:0016020 | membrane |
| CC | IDA | GO:0016328 | lateral plasma membrane |
| CC | IDA | GO:0030425 | dendrite |
| CC | IDA | GO:0097427 | microtubule bundle |
Gene expression in normal tissue: MARK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MARK2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_TNFalpha | TNFalpha |
| pid | lkb1_pathway | LKB1 signaling events |
| pid | notch_pathway | Notch signaling pathway |
| wikipathways | WP2038 | Regulation of Microtubule Cytoskeleton |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD23 | Gossypol | 2 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD441 | TW 37 | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 3 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD781 | Sirolimus | 7 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD144 | NSC95397 | 4 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD599 | Salermide | 2 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD147 | Prima-1 | 3 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD67 | PENFLURIDOL | 2 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD434 | BMS-536924 | 4 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD511 | CHEMBL399379 | 3 |
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD341 | Triacsin c | 1 |
| iGMDRD523 | Cyanoquinoline, 11 | 2 |
| iGMDRD330 | BRD4132 | 2 |
| iGMDRD84 | Lovastatin acid | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MARK2
CLASSFICATION
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