MARK2


Summary: This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
microtubule affinity regulating kinase 2MIM:600526Ensembl:ENSG00000072518HGNC:HGNC:3332PA3504711q13.1

GO terms in MARK2


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0000287magnesium ion binding
MFHDAGO:0003723RNA binding
MFIBAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFISSGO:0004674protein serine/threonine kinase activity
MFNASGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIDAGO:0005524ATP binding
MFIEAGO:0008289lipid binding
MFTASGO:0030295protein kinase activator activity
MFHDAGO:0045296cadherin binding
MFISSGO:0048156tau protein binding
MFIBAGO:0050321tau-protein kinase activity
MFIMPGO:0050321tau-protein kinase activity
MFISSGO:0050321tau-protein kinase activity
BPIBAGO:0000226microtubule cytoskeleton organization
BPNASGO:0000422autophagy of mitochondrion
BPISSGO:0001764neuron migration
BPIDAGO:0006468protein phosphorylation
BPIMPGO:0006468protein phosphorylation
BPNASGO:0006468protein phosphorylation
BPIDAGO:0010976positive regulation of neuron projection development
BPIEAGO:0016055Wnt signaling pathway
BPIDAGO:0018105peptidyl-serine phosphorylation
BPISSGO:0018105peptidyl-serine phosphorylation
BPTASGO:0018107peptidyl-threonine phosphorylation
BPIDAGO:0030010establishment of cell polarity
BPTASGO:0030010establishment of cell polarity
BPTASGO:0032147activation of protein kinase activity
BPIBAGO:0035556intracellular signal transduction
BPIDAGO:0035556intracellular signal transduction
BPIDAGO:0045197establishment or maintenance of epithelial cell apical/basal polarity
BPISSGO:0046777protein autophosphorylation
BPIMPGO:0050770regulation of axonogenesis
BPISSGO:0051493regulation of cytoskeleton organization
BPNASGO:0051646mitochondrion localization
BPISSGO:0061564axon development
BPIDAGO:0070507regulation of microtubule cytoskeleton organization
BPISSGO:0071963establishment or maintenance of cell polarity regulating cell shape
BPISSGO:1904526regulation of microtubule binding
CCIDAGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCNASGO:0005739mitochondrion
CCIDAGO:0005884actin filament
CCIDAGO:0005886plasma membrane
CCIMPGO:0016020membrane
CCIDAGO:0016328lateral plasma membrane
CCIDAGO:0030425dendrite
CCIDAGO:0097427microtubule bundle

Gene expression in normal tissue: MARK2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MARK2


DatabasePathway IDPathway Des.
netpathPathway_TNFalphaTNFalpha
pidlkb1_pathwayLKB1 signaling events
pidnotch_pathwayNotch signaling pathway
wikipathwaysWP2038Regulation of Microtubule Cytoskeleton

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD23Gossypol2
iGMDRD268Cerulenin2
iGMDRD64Parbendazole1
iGMDRD780PP-303
iGMDRD398Sepantronium2
iGMDRD577BIX012942
iGMDRD506Fedratinib2
iGMDRD188Piperlongumine2
iGMDRD870BRD636101
iGMDRD52Rotenone2
iGMDRD318PAC-12
iGMDRD441TW 373
iGMDRD255SB2250023
iGMDRD394BX-7953
iGMDRD639YK 4-2793
iGMDRD316N9-Isopropyl-olomoucine3
iGMDRD446LY 21832401
iGMDRD781Sirolimus7
iGMDRD494Neopeltolide2
iGMDRD144NSC953974
iGMDRD772BRD47702
iGMDRD889Compound 7d-cis2
iGMDRD599Salermide2
iGMDRD126Tipifarnib4
iGMDRD147Prima-13
iGMDRD246NPC262
iGMDRD662JQ-12
iGMDRD871BRD63682
iGMDRD67PENFLURIDOL2
iGMDRD286Nsc 6328394
iGMDRD434BMS-5369244
iGMDRD6AM-5802
iGMDRD289Parthenolide2
iGMDRD132(-)-gallocatechin-3-O-gallate2
iGMDRD511CHEMBL3993793
iGMDRD237ABT-7511
iGMDRD314Tanespimycin3
iGMDRD85Ursolic acid1
iGMDRD341Triacsin c1
iGMDRD523Cyanoquinoline, 112
iGMDRD330BRD41322
iGMDRD84Lovastatin acid3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MARK2

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