SSU72
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| SSU72 homolog, RNA polymerase II CTD phosphatase | MIM:617680 | Ensembl:ENSG00000160075 | HGNC:HGNC:25016 | PA142670866 | 1p36.33 |
Gene Categories:
PROTEIN PHOSPHATASEGO terms in SSU72
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0006369 | termination of RNA polymerase II transcription |
| BP | IBA | GO:0006378 | mRNA polyadenylation |
| BP | IMP | GO:0006378 | mRNA polyadenylation |
| BP | IBA | GO:0070940 | dephosphorylation of RNA polymerase II C-terminal domain |
| BP | IDA | GO:0070940 | dephosphorylation of RNA polymerase II C-terminal domain |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IBA | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008420 | CTD phosphatase activity |
| MF | IDA | GO:0008420 | CTD phosphatase activity |
Gene expression in normal tissue: SSU72
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SSU72
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-6807505 | RNA polymerase II transcribes snRNA genes |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| kegg | hsa03015 | mRNA surveillance pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD255 | SB225002 | 3 |
| iGMDRD270 | Ciclosporin | 3 |
| iGMDRD271 | Brefeldin A | 4 |
| iGMDRD481 | Dactolisib | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 6 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD300 | Tozasertib | 1 |
| iGMDRD679 | Bistramide A | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SSU72
CLASSFICATION
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