NTRK2
Summary: This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| neurotrophic receptor tyrosine kinase 2 | MIM:600456 | Ensembl:ENSG00000148053 | HGNC:HGNC:8032 | PA31818 | 9q21.33 |
GO terms in NTRK2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IBA | GO:0005030 | neurotrophin receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
| MF | ISS | GO:0042803 | protein homodimerization activity |
| MF | IBA | GO:0043121 | neurotrophin binding |
| MF | IDA | GO:0043121 | neurotrophin binding |
| MF | ISS | GO:0043121 | neurotrophin binding |
| MF | IBA | GO:0048403 | brain-derived neurotrophic factor binding |
| MF | ISS | GO:0048403 | brain-derived neurotrophic factor binding |
| MF | IBA | GO:0060175 | brain-derived neurotrophic factor-activated receptor activity |
| MF | IMP | GO:0060175 | brain-derived neurotrophic factor-activated receptor activity |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005769 | early endosome |
| CC | IEA | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0014069 | postsynaptic density |
| CC | IEA | GO:0014069 | postsynaptic density |
| CC | IBA | GO:0030424 | axon |
| CC | IEA | GO:0031901 | early endosome membrane |
| CC | IEA | GO:0043195 | terminal bouton |
| CC | IBA | GO:0043197 | dendritic spine |
| CC | IBA | GO:0043235 | receptor complex |
| CC | IDA | GO:0043235 | receptor complex |
| CC | IBA | GO:0043679 | axon terminus |
| CC | IEA | GO:0045211 | postsynaptic membrane |
| BP | IEA | GO:0001570 | vasculogenesis |
| BP | ISS | GO:0001764 | neuron migration |
| BP | TAS | GO:0001934 | positive regulation of protein phosphorylation |
| BP | TAS | GO:0007202 | activation of phospholipase C activity |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | IEA | GO:0007528 | neuromuscular junction development |
| BP | ISS | GO:0007612 | learning |
| BP | IEA | GO:0007623 | circadian rhythm |
| BP | IEA | GO:0007631 | feeding behavior |
| BP | ISS | GO:0008284 | positive regulation of cell proliferation |
| BP | IBA | GO:0009968 | negative regulation of signal transduction |
| BP | ISS | GO:0010628 | positive regulation of gene expression |
| BP | ISS | GO:0010976 | positive regulation of neuron projection development |
| BP | IEA | GO:0014047 | glutamate secretion |
| BP | ISS | GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | ISS | GO:0021954 | central nervous system neuron development |
| BP | ISS | GO:0021987 | cerebral cortex development |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | ISS | GO:0030182 | neuron differentiation |
| BP | IMP | GO:0031547 | brain-derived neurotrophic factor receptor signaling pathway |
| BP | TAS | GO:0031547 | brain-derived neurotrophic factor receptor signaling pathway |
| BP | IEA | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| BP | IBA | GO:0033674 | positive regulation of kinase activity |
| BP | IEA | GO:0042490 | mechanoreceptor differentiation |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | ISS | GO:0043087 | regulation of GTPase activity |
| BP | IBA | GO:0043410 | positive regulation of MAPK cascade |
| BP | ISS | GO:0043410 | positive regulation of MAPK cascade |
| BP | ISS | GO:0043524 | negative regulation of neuron apoptotic process |
| BP | IEA | GO:0046548 | retinal rod cell development |
| BP | ISS | GO:0046777 | protein autophosphorylation |
| BP | TAS | GO:0048011 | neurotrophin TRK receptor signaling pathway |
| BP | IEA | GO:0048709 | oligodendrocyte differentiation |
| BP | IEA | GO:0048935 | peripheral nervous system neuron development |
| BP | ISS | GO:0050772 | positive regulation of axonogenesis |
| BP | IEA | GO:0051896 | regulation of protein kinase B signaling |
| BP | IEA | GO:0051965 | positive regulation of synapse assembly |
| BP | IEA | GO:0060041 | retina development in camera-type eye |
| BP | IEA | GO:0060291 | long-term synaptic potentiation |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IEA | GO:0071230 | cellular response to amino acid stimulus |
| BP | IBA | GO:0099551 | trans-synaptic signaling by neuropeptide, modulating synaptic transmission |
| BP | IEA | GO:0099551 | trans-synaptic signaling by neuropeptide, modulating synaptic transmission |
| BP | TAS | GO:1903997 | positive regulation of non-membrane spanning protein tyrosine kinase activity |
| BP | IBA | GO:1990090 | cellular response to nerve growth factor stimulus |
| BP | IEA | GO:2000811 | negative regulation of anoikis |
Gene expression in normal tissue: NTRK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NTRK2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_BDNF | BDNF |
| pid | ajdiss_2pathway | Posttranslational regulation of adherens junction stability and dissassembly |
| pid | shp2_pathway | SHP2 signaling |
| pid | trkrpathway | Neurotrophic factor-mediated Trk receptor signaling |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa05034 | Alcoholism - Homo sapiens (human) |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP3676 | BDNF-TrkB Signaling |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3853 | ERK Pathway in Huntington,s Disease |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-187015 | Activation of TRKA receptors |
| reactome | R-HSA-187024 | NGF-independant TRKA activation |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-9006115 | Signaling by NTRK2 (TRKB) |
| reactome | R-HSA-9006115 | Signaling by NTRK2 (TRKB) |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9024909 | BDNF activates NTRK2 (TRKB) signaling |
| reactome | R-HSA-9025046 | NTF3 activates NTRK2 (TRKB) signaling |
| reactome | R-HSA-9026357 | NTF4 activates NTRK2 (TRKB) signaling |
| reactome | R-HSA-9026519 | Activated NTRK2 signals through RAS |
| reactome | R-HSA-9026527 | Activated NTRK2 signals through PLCG1 |
| reactome | R-HSA-9026527 | Activated NTRK2 signals through PLCG1 |
| reactome | R-HSA-9028335 | Activated NTRK2 signals through PI3K |
| reactome | R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 |
| reactome | R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 |
| reactome | R-HSA-9032500 | Activated NTRK2 signals through FYN |
| reactome | R-HSA-9032500 | Activated NTRK2 signals through FYN |
| reactome | R-HSA-9032759 | NTRK2 activates RAC1 |
| reactome | R-HSA-9032759 | NTRK2 activates RAC1 |
| reactome | R-HSA-9032845 | Activated NTRK2 signals through CDK5 |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD103 | SN-38 | 4 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD125 | BIRB-796 | 1 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 2 |
| iGMDRD126 | Tipifarnib | 8 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD280 | CYTOCHALASIN B | 6 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD679 | Bistramide A | 6 |
| iGMDRD211 | (1S,3R)-RSL3 | 1 |
| iGMDRD511 | CHEMBL399379 | 2 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD351 | GW843682X | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NTRK2
CLASSFICATION
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