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NTRK2

Summary: This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameneurotrophic receptor tyrosine kinase 2 OMIM IDMIM:600456 Ensembl IDEnsembl:ENSG00000148053 HGNC IDHGNC:HGNC:8032 PHARMGKB IDPA31818 Map Location9q21.33

Gene Categories:

TYROSINE KINASE DRUGGABLE GENOME CLINICALLY ACTIONABLE KINASE

GO terms in NTRK2

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IBA	GO:0004709	MAP kinase kinase kinase activity
MF	IBA	GO:0004713	protein tyrosine kinase activity
MF	IBA	GO:0004714	transmembrane receptor protein tyrosine kinase activity
MF	IBA	GO:0004888	transmembrane signaling receptor activity
MF	IBA	GO:0005030	neurotrophin receptor activity
MF	IPI	GO:0005515	protein binding

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Gene expression in normal tissue: NTRK2

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NTRK2

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Database	Pathway ID	Pathway Des.
netpath	Pathway_BDNF	BDNF
pid	ajdiss_2pathway	Posttranslational regulation of adherens junction stability and dissassembly
pid	shp2_pathway	SHP2 signaling
pid	trkrpathway	Neurotrophic factor-mediated Trk receptor signaling
kegg	hsa04010	MAPK signaling pathway - Homo sapiens (human)
kegg	hsa04014	Ras signaling pathway - Homo sapiens (human)

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD434	BMS-536924	2
iGMDRD105	Triptolide	2
iGMDRD6	AM-580	3
iGMDRD77	Itraconazole	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NTRK2

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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