NTRK2


Summary: This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
neurotrophic receptor tyrosine kinase 2MIM:600456Ensembl:ENSG00000148053HGNC:HGNC:8032PA318189q21.33

GO terms in NTRK2


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004709MAP kinase kinase kinase activity
MFIBAGO:0004713protein tyrosine kinase activity
MFIBAGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIBAGO:0004888transmembrane signaling receptor activity
MFIBAGO:0005030neurotrophin receptor activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:0031434mitogen-activated protein kinase kinase binding
MFISSGO:0042803protein homodimerization activity
MFIBAGO:0043121neurotrophin binding
MFIDAGO:0043121neurotrophin binding
MFISSGO:0043121neurotrophin binding
MFIBAGO:0048403brain-derived neurotrophic factor binding
MFISSGO:0048403brain-derived neurotrophic factor binding
MFIBAGO:0060175brain-derived neurotrophic factor-activated receptor activity
MFIMPGO:0060175brain-derived neurotrophic factor-activated receptor activity
CCIBAGO:0005737cytoplasm
CCISSGO:0005769early endosome
CCIEAGO:0005829cytosol
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCIDAGO:0005887integral component of plasma membrane
CCIBAGO:0014069postsynaptic density
CCIEAGO:0014069postsynaptic density
CCIBAGO:0030424axon
CCIEAGO:0031901early endosome membrane
CCIEAGO:0043195terminal bouton
CCIBAGO:0043197dendritic spine
CCIBAGO:0043235receptor complex
CCIDAGO:0043235receptor complex
CCIBAGO:0043679axon terminus
CCIEAGO:0045211postsynaptic membrane
BPIEAGO:0001570vasculogenesis
BPISSGO:0001764neuron migration
BPTASGO:0001934positive regulation of protein phosphorylation
BPTASGO:0007202activation of phospholipase C activity
BPIBAGO:0007275multicellular organism development
BPIEAGO:0007528neuromuscular junction development
BPISSGO:0007612learning
BPIEAGO:0007623circadian rhythm
BPIEAGO:0007631feeding behavior
BPISSGO:0008284positive regulation of cell proliferation
BPIBAGO:0009968negative regulation of signal transduction
BPISSGO:0010628positive regulation of gene expression
BPISSGO:0010976positive regulation of neuron projection development
BPIEAGO:0014047glutamate secretion
BPISSGO:0014068positive regulation of phosphatidylinositol 3-kinase signaling
BPIEAGO:0018108peptidyl-tyrosine phosphorylation
BPISSGO:0021954central nervous system neuron development
BPISSGO:0021987cerebral cortex development
BPIBAGO:0030154cell differentiation
BPISSGO:0030182neuron differentiation
BPIMPGO:0031547brain-derived neurotrophic factor receptor signaling pathway
BPTASGO:0031547brain-derived neurotrophic factor receptor signaling pathway
BPIEAGO:0033138positive regulation of peptidyl-serine phosphorylation
BPIBAGO:0033674positive regulation of kinase activity
BPIEAGO:0042490mechanoreceptor differentiation
BPIBAGO:0043066negative regulation of apoptotic process
BPISSGO:0043087regulation of GTPase activity
BPIBAGO:0043410positive regulation of MAPK cascade
BPISSGO:0043410positive regulation of MAPK cascade
BPISSGO:0043524negative regulation of neuron apoptotic process
BPIEAGO:0046548retinal rod cell development
BPISSGO:0046777protein autophosphorylation
BPTASGO:0048011neurotrophin TRK receptor signaling pathway
BPIEAGO:0048709oligodendrocyte differentiation
BPIEAGO:0048935peripheral nervous system neuron development
BPISSGO:0050772positive regulation of axonogenesis
BPIEAGO:0051896regulation of protein kinase B signaling
BPIEAGO:0051965positive regulation of synapse assembly
BPIEAGO:0060041retina development in camera-type eye
BPIEAGO:0060291long-term synaptic potentiation
BPIBAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIEAGO:0071230cellular response to amino acid stimulus
BPIBAGO:0099551trans-synaptic signaling by neuropeptide, modulating synaptic transmission
BPIEAGO:0099551trans-synaptic signaling by neuropeptide, modulating synaptic transmission
BPTASGO:1903997positive regulation of non-membrane spanning protein tyrosine kinase activity
BPIBAGO:1990090cellular response to nerve growth factor stimulus
BPIEAGO:2000811negative regulation of anoikis

Gene expression in normal tissue: NTRK2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NTRK2


DatabasePathway IDPathway Des.
netpathPathway_BDNFBDNF
pidajdiss_2pathwayPosttranslational regulation of adherens junction stability and dissassembly
pidshp2_pathwaySHP2 signaling
pidtrkrpathwayNeurotrophic factor-mediated Trk receptor signaling
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa05034Alcoholism - Homo sapiens (human)
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP3676BDNF-TrkB Signaling
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3853ERK Pathway in Huntington,s Disease
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4223Ras Signaling
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-187015Activation of TRKA receptors
reactomeR-HSA-187024NGF-independant TRKA activation
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-9006115Signaling by NTRK2 (TRKB)
reactomeR-HSA-9006115Signaling by NTRK2 (TRKB)
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9024909BDNF activates NTRK2 (TRKB) signaling
reactomeR-HSA-9025046NTF3 activates NTRK2 (TRKB) signaling
reactomeR-HSA-9026357NTF4 activates NTRK2 (TRKB) signaling
reactomeR-HSA-9026519Activated NTRK2 signals through RAS
reactomeR-HSA-9026527Activated NTRK2 signals through PLCG1
reactomeR-HSA-9026527Activated NTRK2 signals through PLCG1
reactomeR-HSA-9028335Activated NTRK2 signals through PI3K
reactomeR-HSA-9028731Activated NTRK2 signals through FRS2 and FRS3
reactomeR-HSA-9028731Activated NTRK2 signals through FRS2 and FRS3
reactomeR-HSA-9032500Activated NTRK2 signals through FYN
reactomeR-HSA-9032500Activated NTRK2 signals through FYN
reactomeR-HSA-9032759NTRK2 activates RAC1
reactomeR-HSA-9032759NTRK2 activates RAC1
reactomeR-HSA-9032845Activated NTRK2 signals through CDK5

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD434BMS-5369242
iGMDRD105Triptolide2
iGMDRD6AM-5803
iGMDRD77Itraconazole3
iGMDRD103SN-384
iGMDRD871BRD63683
iGMDRD414MST-3123
iGMDRD367Ro 28-16753
iGMDRD780PP-303
iGMDRD329Merck603
iGMDRD116CD4373
iGMDRD125BIRB-7961
iGMDRD405PIK-753
iGMDRD701NVP-AUY9223
iGMDRD523Cyanoquinoline, 112
iGMDRD126Tipifarnib8
iGMDRD123Isoevodiamine4
iGMDRD280CYTOCHALASIN B6
iGMDRD177Teniposide2
iGMDRD679Bistramide A6
iGMDRD211(1S,3R)-RSL31
iGMDRD511CHEMBL3993792
iGMDRD237ABT-7512
iGMDRD351GW843682X5

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NTRK2

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