NKD2
Summary: This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| naked cuticle homolog 2 | MIM:607852 | Ensembl:ENSG00000145506 | HGNC:HGNC:17046 | PA31638 | 5p15.33 |
GO terms in NKD2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006887 | exocytosis |
| BP | IDA | GO:0010954 | positive regulation of protein processing |
| BP | IEA | GO:0016055 | Wnt signaling pathway |
| BP | IBA | GO:0030178 | negative regulation of Wnt signaling pathway |
| BP | IMP | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | IMP | GO:0048210 | Golgi vesicle fusion to target membrane |
| BP | IMP | GO:0072659 | protein localization to plasma membrane |
| BP | IDA | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | IMP | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | IDA | GO:1903078 | positive regulation of protein localization to plasma membrane |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0016323 | basolateral plasma membrane |
| CC | IDA | GO:0016328 | lateral plasma membrane |
| CC | IDA | GO:0031410 | cytoplasmic vesicle |
| CC | IDA | GO:0070382 | exocytic vesicle |
| CC | IDA | GO:0071944 | cell periphery |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019838 | growth factor binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IPI | GO:0032036 | myosin heavy chain binding |
| MF | IPI | GO:0051117 | ATPase binding |
Gene expression in normal tissue: NKD2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NKD2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | gsk3pathway | inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages |
| biocarta | hespathway | segmentation clock |
| biocarta | pitx2pathway | multi-step regulation of transcription by pitx2 |
| biocarta | wntpathway | wnt signaling pathway |
| wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
| wikipathways | WP428 | Wnt Signaling Pathway |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| pid | wnt_canonical_pathway | Canonical Wnt signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD116 | CD437 | 2 |
| iGMDRD150 | RITA | 3 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 6 |
| iGMDRD61 | Kinetin riboside | 6 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD366 | PI-103 | 2 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD414 | MST-312 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NKD2
CLASSFICATION
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