NKD2

Summary: This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namenaked cuticle homolog 2
OMIM IDMIM:607852
Ensembl IDEnsembl:ENSG00000145506
HGNC IDHGNC:HGNC:17046
PHARMGKB IDPA31638
Map Location5p15.33

GO terms in NKD2


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0006887 exocytosis
BP IDA GO:0010954 positive regulation of protein processing
BP IEA GO:0016055 Wnt signaling pathway
BP IBA GO:0030178 negative regulation of Wnt signaling pathway
BP IMP GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
BP IMP GO:0048210 Golgi vesicle fusion to target membrane
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Gene expression in normal tissue: NKD2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined13Apoptosis regulation1Ferroptosis1PI3K/MTOR signaling1

Pathways in NKD2


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Database
Pathway ID
Pathway Des.
biocarta gsk3pathway inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages
biocarta hespathway segmentation clock
biocarta pitx2pathway multi-step regulation of transcription by pitx2
biocarta wntpathway wnt signaling pathway
wikipathways WP399 Wnt Signaling Pathway and Pluripotency
wikipathways WP428 Wnt Signaling Pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD523 Cyanoquinoline, 11 3
iGMDRD670 ML 210 3
iGMDRD116 CD437 2
iGMDRD150 RITA 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NKD2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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