RARB


Summary: This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
retinoic acid receptor betaMIM:180220Ensembl:ENSG00000077092HGNC:HGNC:9865PA342263p24.2

GO terms in RARB


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0000976transcription regulatory region sequence-specific DNA binding
MFIBAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFIEAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIBAGO:0001076transcription factor activity, RNA polymerase II transcription factor binding
MFTASGO:0003677DNA binding
MFIBAGO:0003700DNA-binding transcription factor activity
MFIEAGO:0003707steroid hormone receptor activity
MFIBAGO:0003708retinoic acid receptor activity
MFIEAGO:0003708retinoic acid receptor activity
MFIBAGO:0004879nuclear receptor activity
MFIBAGO:0008134transcription factor binding
MFIEAGO:0008144drug binding
MFIEAGO:0008270zinc ion binding
MFIBAGO:0030374nuclear receptor transcription coactivator activity
MFIEAGO:0044877protein-containing complex binding
MFIEAGO:0046965retinoid X receptor binding
MFIBAGO:0098531transcription factor activity, direct ligand regulated sequence-specific DNA binding
BPIBAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0001657ureteric bud development
BPIBAGO:0001889liver development
BPIEAGO:0002068glandular epithelial cell development
BPIEAGO:0003148outflow tract septum morphogenesis
BPIEAGO:0003406retinal pigment epithelium development
BPIEAGO:0003417growth plate cartilage development
BPTASGO:0006367transcription initiation from RNA polymerase II promoter
BPTASGO:0007165signal transduction
BPIBAGO:0007275multicellular organism development
BPIBAGO:0007420brain development
BPIBAGO:0007507heart development
BPIEAGO:0008284positive regulation of cell proliferation
BPIEAGO:0008285negative regulation of cell proliferation
BPIBAGO:0009755hormone-mediated signaling pathway
BPIEAGO:0021756striatum development
BPIBAGO:0030154cell differentiation
BPIBAGO:0030855epithelial cell differentiation
BPIEAGO:0031641regulation of myelination
BPIEAGO:0032331negative regulation of chondrocyte differentiation
BPIBAGO:0032526response to retinoic acid
BPIBAGO:0033993response to lipid
BPIEAGO:0035116embryonic hindlimb morphogenesis
BPIEAGO:0035264multicellular organism growth
BPIEAGO:0043065positive regulation of apoptotic process
BPIEAGO:0043066negative regulation of apoptotic process
BPIEAGO:0043401steroid hormone mediated signaling pathway
BPIEAGO:0045666positive regulation of neuron differentiation
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0048048embryonic eye morphogenesis
BPIBAGO:0048384retinoic acid receptor signaling pathway
BPIEAGO:0048384retinoic acid receptor signaling pathway
BPIMPGO:0048566embryonic digestive tract development
BPIBAGO:0048568embryonic organ development
BPIBAGO:0048732gland development
BPIEAGO:0055012ventricular cardiac muscle cell differentiation
BPIBAGO:0060349bone morphogenesis
BPIBAGO:0060429epithelium development
BPIBAGO:0071300cellular response to retinoic acid
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIEAGO:0005737cytoplasm
CCIBAGO:0090575RNA polymerase II transcription factor complex

Gene expression in normal tissue: RARB

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RARB


DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-383280Nuclear Receptor transcription pathway
reactomeR-HSA-5362517Signaling by Retinoic Acid
reactomeR-HSA-5617472Activation of anterior HOX genes in hindbrain development during early embryogenesis
reactomeR-HSA-5619507Activation of HOX genes during differentiation
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-9006931Signaling by Nuclear Receptors
wikipathwaysWP170Nuclear Receptors
wikipathwaysWP2857Mesodermal Commitment Pathway
wikipathwaysWP299Nuclear Receptors in Lipid Metabolism and Toxicity
wikipathwaysWP716Vitamin A and Carotenoid Metabolism
pidretinoic_acid_pathwayRetinoic acid receptors-mediated signaling
pidrxr_vdr_pathwayRXR and RAR heterodimerization with other nuclear receptor
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05222Small cell lung cancer - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD137Indisulam1
iGMDRD158NSC1415402
iGMDRD270Ciclosporin2
iGMDRD434BMS-5369243
iGMDRD77Itraconazole2
iGMDRD887Compound 23 citrate3
iGMDRD871BRD63685
iGMDRD398Sepantronium3
iGMDRD506Fedratinib4
iGMDRD640CAY106183
iGMDRD60Quinoclamine3
iGMDRD126Tipifarnib1
iGMDRD1008SR-II-138A3
iGMDRD546BMS-7548072
iGMDRD701NVP-AUY9221
iGMDRD781Sirolimus3
iGMDRD523Cyanoquinoline, 113
iGMDRD494Neopeltolide3
iGMDRD341Triacsin c2
iGMDRD237ABT-7513
iGMDRD219Bax channel blocker1
iGMDRD679Bistramide A4
iGMDRD280CYTOCHALASIN B4
iGMDRD297Austocystin D1
iGMDRD375GW-4058333

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RARB

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