RARB
Summary: This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| retinoic acid receptor beta | MIM:180220 | Ensembl:ENSG00000077092 | HGNC:HGNC:9865 | PA34226 | 3p24.2 |
GO terms in RARB
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000976 | transcription regulatory region sequence-specific DNA binding |
| MF | IBA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | IEA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IBA | GO:0001076 | transcription factor activity, RNA polymerase II transcription factor binding |
| MF | TAS | GO:0003677 | DNA binding |
| MF | IBA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IEA | GO:0003707 | steroid hormone receptor activity |
| MF | IBA | GO:0003708 | retinoic acid receptor activity |
| MF | IEA | GO:0003708 | retinoic acid receptor activity |
| MF | IBA | GO:0004879 | nuclear receptor activity |
| MF | IBA | GO:0008134 | transcription factor binding |
| MF | IEA | GO:0008144 | drug binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IBA | GO:0030374 | nuclear receptor transcription coactivator activity |
| MF | IEA | GO:0044877 | protein-containing complex binding |
| MF | IEA | GO:0046965 | retinoid X receptor binding |
| MF | IBA | GO:0098531 | transcription factor activity, direct ligand regulated sequence-specific DNA binding |
| BP | IBA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0001657 | ureteric bud development |
| BP | IBA | GO:0001889 | liver development |
| BP | IEA | GO:0002068 | glandular epithelial cell development |
| BP | IEA | GO:0003148 | outflow tract septum morphogenesis |
| BP | IEA | GO:0003406 | retinal pigment epithelium development |
| BP | IEA | GO:0003417 | growth plate cartilage development |
| BP | TAS | GO:0006367 | transcription initiation from RNA polymerase II promoter |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | IBA | GO:0007420 | brain development |
| BP | IBA | GO:0007507 | heart development |
| BP | IEA | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0008285 | negative regulation of cell proliferation |
| BP | IBA | GO:0009755 | hormone-mediated signaling pathway |
| BP | IEA | GO:0021756 | striatum development |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IBA | GO:0030855 | epithelial cell differentiation |
| BP | IEA | GO:0031641 | regulation of myelination |
| BP | IEA | GO:0032331 | negative regulation of chondrocyte differentiation |
| BP | IBA | GO:0032526 | response to retinoic acid |
| BP | IBA | GO:0033993 | response to lipid |
| BP | IEA | GO:0035116 | embryonic hindlimb morphogenesis |
| BP | IEA | GO:0035264 | multicellular organism growth |
| BP | IEA | GO:0043065 | positive regulation of apoptotic process |
| BP | IEA | GO:0043066 | negative regulation of apoptotic process |
| BP | IEA | GO:0043401 | steroid hormone mediated signaling pathway |
| BP | IEA | GO:0045666 | positive regulation of neuron differentiation |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0048048 | embryonic eye morphogenesis |
| BP | IBA | GO:0048384 | retinoic acid receptor signaling pathway |
| BP | IEA | GO:0048384 | retinoic acid receptor signaling pathway |
| BP | IMP | GO:0048566 | embryonic digestive tract development |
| BP | IBA | GO:0048568 | embryonic organ development |
| BP | IBA | GO:0048732 | gland development |
| BP | IEA | GO:0055012 | ventricular cardiac muscle cell differentiation |
| BP | IBA | GO:0060349 | bone morphogenesis |
| BP | IBA | GO:0060429 | epithelium development |
| BP | IBA | GO:0071300 | cellular response to retinoic acid |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0090575 | RNA polymerase II transcription factor complex |
Gene expression in normal tissue: RARB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RARB
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-383280 | Nuclear Receptor transcription pathway |
| reactome | R-HSA-5362517 | Signaling by Retinoic Acid |
| reactome | R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| reactome | R-HSA-5619507 | Activation of HOX genes during differentiation |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
| wikipathways | WP170 | Nuclear Receptors |
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| wikipathways | WP299 | Nuclear Receptors in Lipid Metabolism and Toxicity |
| wikipathways | WP716 | Vitamin A and Carotenoid Metabolism |
| pid | retinoic_acid_pathway | Retinoic acid receptors-mediated signaling |
| pid | rxr_vdr_pathway | RXR and RAR heterodimerization with other nuclear receptor |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05222 | Small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD137 | Indisulam | 1 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD270 | Ciclosporin | 2 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD871 | BRD6368 | 5 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD506 | Fedratinib | 4 |
| iGMDRD640 | CAY10618 | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD126 | Tipifarnib | 1 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD701 | NVP-AUY922 | 1 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD219 | Bax channel blocker | 1 |
| iGMDRD679 | Bistramide A | 4 |
| iGMDRD280 | CYTOCHALASIN B | 4 |
| iGMDRD297 | Austocystin D | 1 |
| iGMDRD375 | GW-405833 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RARB
CLASSFICATION
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