RAP1GDS1


Summary: The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993 [PubMed 8262526]).[supplied by OMIM, Feb 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
Rap1 GTPase-GDP dissociation stimulator 1MIM:179502Ensembl:ENSG00000138698HGNC:HGNC:9859PA342214q23

GO terms in RAP1GDS1


Term TypeEvidence TypeGO Term IDGO Des.
MFNASGO:0005096GTPase activator activity
MFIPIGO:0005515protein binding
BPIBAGO:0007264small GTPase mediated signal transduction
BPIEAGO:0014829vascular smooth muscle contraction
BPIEAGO:0031034myosin filament assembly
BPIMPGO:0032471negative regulation of endoplasmic reticulum calcium ion concentration
BPIBAGO:0043547positive regulation of GTPase activity
BPIMPGO:0051561positive regulation of mitochondrial calcium ion concentration
CCIDAGO:0005739mitochondrion
CCIDAGO:0005783endoplasmic reticulum
CCIBAGO:0005829cytosol
CCIDAGO:0005829cytosol
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: RAP1GDS1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RAP1GDS1


DatabasePathway IDPathway Des.
pidrac1_reg_pathwayRegulation of RAC1 activity

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD506Fedratinib6
iGMDRD662JQ-13
iGMDRD871BRD63686
iGMDRD356PNU-746543
iGMDRD52Rotenone6
iGMDRD481Dactolisib3
iGMDRD314Tanespimycin3
iGMDRD435BI-25366
iGMDRD634SCHEMBL26080411
iGMDRD359OSW-13
iGMDRD123Isoevodiamine6
iGMDRD280CYTOCHALASIN B6
iGMDRD394BX-7956
iGMDRD177Teniposide3
iGMDRD1008SR-II-138A6
iGMDRD420Leucascandrolide A6
iGMDRD512nutlin 33
iGMDRD781Sirolimus6
iGMDRD523Cyanoquinoline, 116
iGMDRD546BMS-7548076
iGMDRD424Tamatinib3
iGMDRD150RITA3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RAP1GDS1

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