RAP1GDS1
Summary: The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993 [PubMed 8262526]).[supplied by OMIM, Feb 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Rap1 GTPase-GDP dissociation stimulator 1 | MIM:179502 | Ensembl:ENSG00000138698 | HGNC:HGNC:9859 | PA34221 | 4q23 |
GO terms in RAP1GDS1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | NAS | GO:0005096 | GTPase activator activity |
| MF | IPI | GO:0005515 | protein binding |
| BP | IBA | GO:0007264 | small GTPase mediated signal transduction |
| BP | IEA | GO:0014829 | vascular smooth muscle contraction |
| BP | IEA | GO:0031034 | myosin filament assembly |
| BP | IMP | GO:0032471 | negative regulation of endoplasmic reticulum calcium ion concentration |
| BP | IBA | GO:0043547 | positive regulation of GTPase activity |
| BP | IMP | GO:0051561 | positive regulation of mitochondrial calcium ion concentration |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: RAP1GDS1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD506 | Fedratinib | 6 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD871 | BRD6368 | 6 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD52 | Rotenone | 6 |
| iGMDRD481 | Dactolisib | 3 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD435 | BI-2536 | 6 |
| iGMDRD634 | SCHEMBL2608041 | 1 |
| iGMDRD359 | OSW-1 | 3 |
| iGMDRD123 | Isoevodiamine | 6 |
| iGMDRD280 | CYTOCHALASIN B | 6 |
| iGMDRD394 | BX-795 | 6 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD1008 | SR-II-138A | 6 |
| iGMDRD420 | Leucascandrolide A | 6 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD781 | Sirolimus | 6 |
| iGMDRD523 | Cyanoquinoline, 11 | 6 |
| iGMDRD546 | BMS-754807 | 6 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD150 | RITA | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RAP1GDS1
CLASSFICATION
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