PIK3R2
Summary: Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2012].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:603157 Ensembl IDEnsembl:ENSG00000105647 HGNC IDHGNC:HGNC:8980 PHARMGKB IDPA33313 Map Location19p13.11 |
GO terms in PIK3R2
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | ISS | GO:0005634 | nucleus |
CC | TAS | GO:0005829 | cytosol |
CC | IBA | GO:0005942 | phosphatidylinositol 3-kinase complex |
BP | ISS | GO:0001678 | cellular glucose homeostasis |
BP | IBA | GO:0008286 | insulin receptor signaling pathway |
BP | IMP | GO:0010506 | regulation of autophagy |
Gene expression in normal tissue: PIK3R2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PIK3R2
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Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP127 | IL-5 Signaling Pathway |
wikipathways | WP138 | Androgen receptor signaling pathway |
wikipathways | WP1403 | AMP-activated Protein Kinase (AMPK) Signaling |
wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
wikipathways | WP185 | Integrin-mediated Cell Adhesion |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in PIK3R2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |