PIK3R2


Summary: Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2012].

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GO terms in PIK3R2


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Term Type
Evidence Type
GO Term ID
GO Des.
CC ISS GO:0005634 nucleus
CC TAS GO:0005829 cytosol
CC IBA GO:0005942 phosphatidylinositol 3-kinase complex
BP ISS GO:0001678 cellular glucose homeostasis
BP IBA GO:0008286 insulin receptor signaling pathway
BP IMP GO:0010506 regulation of autophagy
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Gene expression in normal tissue: PIK3R2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PIK3R2


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Database
Pathway ID
Pathway Des.
wikipathways WP127 IL-5 Signaling Pathway
wikipathways WP138 Androgen receptor signaling pathway
wikipathways WP1403 AMP-activated Protein Kinase (AMPK) Signaling
wikipathways WP1449 Regulation of toll-like receptor signaling pathway
wikipathways WP1544 MicroRNAs in cardiomyocyte hypertrophy
wikipathways WP185 Integrin-mediated Cell Adhesion
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD945 ML214 5
iGMDRD123 Isoevodiamine 3
iGMDRD237 ABT-751 3
iGMDRD193 Fqi1 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PIK3R2

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Cancer
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