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PIK3R2

Summary: Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2012].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namephosphoinositide-3-kinase regulatory subunit 2 OMIM IDMIM:603157 Ensembl IDEnsembl:ENSG00000105647 HGNC IDHGNC:HGNC:8980 PHARMGKB IDPA33313 Map Location19p13.11

Gene Categories:

LIPID KINASE DRUGGABLE GENOME CLINICALLY ACTIONABLE PHOSPHATIDYLINOSITOL 3 KINASE KINASE

GO terms in PIK3R2

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Term Type	Evidence Type	GO Term ID	GO Des.
CC	ISS	GO:0005634	nucleus
CC	TAS	GO:0005829	cytosol
CC	IBA	GO:0005942	phosphatidylinositol 3-kinase complex
BP	ISS	GO:0001678	cellular glucose homeostasis
BP	IBA	GO:0008286	insulin receptor signaling pathway
BP	IMP	GO:0010506	regulation of autophagy

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Gene expression in normal tissue: PIK3R2

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PIK3R2

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Database	Pathway ID	Pathway Des.
wikipathways	WP127	IL-5 Signaling Pathway
wikipathways	WP138	Androgen receptor signaling pathway
wikipathways	WP1403	AMP-activated Protein Kinase (AMPK) Signaling
wikipathways	WP1449	Regulation of toll-like receptor signaling pathway
wikipathways	WP1544	MicroRNAs in cardiomyocyte hypertrophy
wikipathways	WP185	Integrin-mediated Cell Adhesion

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD945	ML214	5
iGMDRD123	Isoevodiamine	3
iGMDRD237	ABT-751	3
iGMDRD193	Fqi1	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PIK3R2

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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