GLI2


Summary: This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:165230
PHARMGKB IDPA28721
Map Location2q14.2

GO terms in GLI2


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding
MF ISA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF NAS GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF IEA GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MF IDA GO:0003700 DNA-binding transcription factor activity
MF IPI GO:0005515 protein binding
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Gene expression in normal tissue: GLI2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined40Protein stability and degradation1PI3K/MTOR signaling1Chromatin histone methylation1Th17 cell differentiation1Proteasome1Biosynthesis of secondary metabolites1Apoptosis regulation1

Pathways in GLI2


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Database
Pathway ID
Pathway Des.
wikipathways WP2855 Dopaminergic Neurogenesis
wikipathways WP3316 Hedgehog ,off, state
wikipathways WP4204 Tumor suppressor activity of SMARCB1
wikipathways WP4249 Hedgehog Signaling Pathway
wikipathways WP47 Hedgehog Signaling Pathway
kegg hsa04340 Hedgehog signaling pathway - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD144 NSC95397 5
iGMDRD427 ABT737 3
iGMDRD483 SCH-529074 1
iGMDRD1008 SR-II-138A 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GLI2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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