GLI2
Summary: This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| GLI family zinc finger 2 | MIM:165230 | Ensembl:ENSG00000074047 | HGNC:HGNC:4318 | PA28721 | 2q14.2 |
GO terms in GLI2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IDA | GO:0008270 | zinc ion binding |
| MF | IDA | GO:0043565 | sequence-specific DNA binding |
| MF | IDA | GO:1990841 | promoter-specific chromatin binding |
| BP | IMP | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0001501 | skeletal system development |
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | ISS | GO:0001822 | kidney development |
| BP | IEA | GO:0002062 | chondrocyte differentiation |
| BP | ISS | GO:0002076 | osteoblast development |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | IDA | GO:0007224 | smoothened signaling pathway |
| BP | ISS | GO:0007389 | pattern specification process |
| BP | ISS | GO:0007411 | axon guidance |
| BP | ISS | GO:0007418 | ventral midline development |
| BP | ISS | GO:0007442 | hindgut morphogenesis |
| BP | ISS | GO:0007507 | heart development |
| BP | IDA | GO:0008283 | cell proliferation |
| BP | IEA | GO:0008589 | regulation of smoothened signaling pathway |
| BP | IEA | GO:0009612 | response to mechanical stimulus |
| BP | IEA | GO:0009952 | anterior/posterior pattern specification |
| BP | ISS | GO:0009954 | proximal/distal pattern formation |
| BP | ISS | GO:0021508 | floor plate formation |
| BP | ISS | GO:0021513 | spinal cord dorsal/ventral patterning |
| BP | ISS | GO:0021517 | ventral spinal cord development |
| BP | ISS | GO:0021696 | cerebellar cortex morphogenesis |
| BP | ISS | GO:0021775 | smoothened signaling pathway involved in ventral spinal cord interneuron specification |
| BP | IEA | GO:0021776 | smoothened signaling pathway involved in spinal cord motor neuron cell fate specification |
| BP | IEA | GO:0021938 | smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation |
| BP | ISS | GO:0021965 | spinal cord ventral commissure morphogenesis |
| BP | ISS | GO:0021983 | pituitary gland development |
| BP | ISS | GO:0030324 | lung development |
| BP | ISS | GO:0030879 | mammary gland development |
| BP | ISS | GO:0030902 | hindbrain development |
| BP | IEA | GO:0032331 | negative regulation of chondrocyte differentiation |
| BP | ISS | GO:0033089 | positive regulation of T cell differentiation in thymus |
| BP | ISS | GO:0035295 | tube development |
| BP | ISS | GO:0042475 | odontogenesis of dentin-containing tooth |
| BP | IEA | GO:0042733 | embryonic digit morphogenesis |
| BP | IEA | GO:0043066 | negative regulation of apoptotic process |
| BP | IEA | GO:0045666 | positive regulation of neuron differentiation |
| BP | IDA | GO:0045740 | positive regulation of DNA replication |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0048566 | embryonic digestive tract development |
| BP | ISS | GO:0048589 | developmental growth |
| BP | ISS | GO:0048666 | neuron development |
| BP | ISS | GO:0048754 | branching morphogenesis of an epithelial tube |
| BP | IEA | GO:0060032 | notochord regression |
| BP | IEA | GO:0060513 | prostatic bud formation |
| BP | IEA | GO:0060603 | mammary gland duct morphogenesis |
| BP | IEA | GO:0060831 | smoothened signaling pathway involved in dorsal/ventral neural tube patterning |
| BP | IEA | GO:0071407 | cellular response to organic cyclic compound |
| BP | IEA | GO:0090103 | cochlea morphogenesis |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005730 | nucleolus |
| CC | TAS | GO:0005829 | cytosol |
| CC | ISS | GO:0005929 | cilium |
| CC | IEA | GO:0005930 | axoneme |
| CC | IEA | GO:0016020 | membrane |
| CC | IEA | GO:0016607 | nuclear speck |
| CC | IEA | GO:0031514 | motile cilium |
| CC | TAS | GO:0097542 | ciliary tip |
| CC | TAS | GO:0097546 | ciliary base |
Gene expression in normal tissue: GLI2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GLI2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2855 | Dopaminergic Neurogenesis |
| wikipathways | WP3316 | Hedgehog ,off, state |
| wikipathways | WP4204 | Tumor suppressor activity of SMARCB1 |
| wikipathways | WP4249 | Hedgehog Signaling Pathway |
| wikipathways | WP47 | Hedgehog Signaling Pathway |
| kegg | hsa04340 | Hedgehog signaling pathway - Homo sapiens (human) |
| kegg | hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05217 | Basal cell carcinoma - Homo sapiens (human) |
| pid | hedgehog_2pathway | Signaling events mediated by the Hedgehog family |
| pid | hedgehog_glipathway | Hedgehog signaling events mediated by Gli proteins |
| netpath | Pathway_Hedgehog | Hedgehog |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-5358351 | Signaling by Hedgehog |
| reactome | R-HSA-5358351 | Signaling by Hedgehog |
| reactome | R-HSA-5610783 | Degradation of GLI2 by the proteasome |
| reactome | R-HSA-5610787 | Hedgehog 'off' state |
| reactome | R-HSA-5610787 | Hedgehog 'off' state |
| reactome | R-HSA-5632684 | Hedgehog 'on' state |
| reactome | R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878166 | Transcriptional regulation by RUNX2 |
| reactome | R-HSA-8941284 | RUNX2 regulates chondrocyte maturation |
| reactome | R-HSA-8941326 | RUNX2 regulates bone development |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD144 | NSC95397 | 5 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD483 | SCH-529074 | 1 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD394 | BX-795 | 6 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD359 | OSW-1 | 2 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD639 | YK 4-279 | 2 |
| iGMDRD52 | Rotenone | 5 |
| iGMDRD885 | Compound 110 | 5 |
| iGMDRD270 | Ciclosporin | 2 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD730 | Kahalalide F | 2 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD562 | Navitoclax | 5 |
| iGMDRD577 | BIX01294 | 8 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD652 | UNC0638 | 2 |
| iGMDRD701 | NVP-AUY922 | 2 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD584 | VER 155008 | 1 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD698 | Neratinib | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 5 |
| iGMDRD705 | Nakiterpiosin | 1 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD1006 | SMO inhibitor | 1 |
| iGMDRD231 | Importazole | 1 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD481 | Dactolisib | 2 |
| iGMDRD505 | Pevonedistat | 5 |
| iGMDRD286 | Nsc 632839 | 1 |
| iGMDRD871 | BRD6368 | 6 |
| iGMDRD329 | Merck60 | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GLI2
CLASSFICATION
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