GLI2


Summary: This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
GLI family zinc finger 2MIM:165230Ensembl:ENSG00000074047HGNC:HGNC:4318PA287212q14.2

GO terms in GLI2


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIDAGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding
MFIPIGO:0008134transcription factor binding
MFIDAGO:0008270zinc ion binding
MFIDAGO:0043565sequence-specific DNA binding
MFIDAGO:1990841promoter-specific chromatin binding
BPIMPGO:0000122negative regulation of transcription by RNA polymerase II
BPISSGO:0001501skeletal system development
BPIEAGO:0001701in utero embryonic development
BPISSGO:0001822kidney development
BPIEAGO:0002062chondrocyte differentiation
BPISSGO:0002076osteoblast development
BPIEAGO:0006366transcription by RNA polymerase II
BPIDAGO:0007224smoothened signaling pathway
BPISSGO:0007389pattern specification process
BPISSGO:0007411axon guidance
BPISSGO:0007418ventral midline development
BPISSGO:0007442hindgut morphogenesis
BPISSGO:0007507heart development
BPIDAGO:0008283cell proliferation
BPIEAGO:0008589regulation of smoothened signaling pathway
BPIEAGO:0009612response to mechanical stimulus
BPIEAGO:0009952anterior/posterior pattern specification
BPISSGO:0009954proximal/distal pattern formation
BPISSGO:0021508floor plate formation
BPISSGO:0021513spinal cord dorsal/ventral patterning
BPISSGO:0021517ventral spinal cord development
BPISSGO:0021696cerebellar cortex morphogenesis
BPISSGO:0021775smoothened signaling pathway involved in ventral spinal cord interneuron specification
BPIEAGO:0021776smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
BPIEAGO:0021938smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
BPISSGO:0021965spinal cord ventral commissure morphogenesis
BPISSGO:0021983pituitary gland development
BPISSGO:0030324lung development
BPISSGO:0030879mammary gland development
BPISSGO:0030902hindbrain development
BPIEAGO:0032331negative regulation of chondrocyte differentiation
BPISSGO:0033089positive regulation of T cell differentiation in thymus
BPISSGO:0035295tube development
BPISSGO:0042475odontogenesis of dentin-containing tooth
BPIEAGO:0042733embryonic digit morphogenesis
BPIEAGO:0043066negative regulation of apoptotic process
BPIEAGO:0045666positive regulation of neuron differentiation
BPIDAGO:0045740positive regulation of DNA replication
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPISSGO:0048566embryonic digestive tract development
BPISSGO:0048589developmental growth
BPISSGO:0048666neuron development
BPISSGO:0048754branching morphogenesis of an epithelial tube
BPIEAGO:0060032notochord regression
BPIEAGO:0060513prostatic bud formation
BPIEAGO:0060603mammary gland duct morphogenesis
BPIEAGO:0060831smoothened signaling pathway involved in dorsal/ventral neural tube patterning
BPIEAGO:0071407cellular response to organic cyclic compound
BPIEAGO:0090103cochlea morphogenesis
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005730nucleolus
CCTASGO:0005829cytosol
CCISSGO:0005929cilium
CCIEAGO:0005930axoneme
CCIEAGO:0016020membrane
CCIEAGO:0016607nuclear speck
CCIEAGO:0031514motile cilium
CCTASGO:0097542ciliary tip
CCTASGO:0097546ciliary base

Gene expression in normal tissue: GLI2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GLI2


DatabasePathway IDPathway Des.
wikipathwaysWP2855Dopaminergic Neurogenesis
wikipathwaysWP3316Hedgehog ,off, state
wikipathwaysWP4204Tumor suppressor activity of SMARCB1
wikipathwaysWP4249Hedgehog Signaling Pathway
wikipathwaysWP47Hedgehog Signaling Pathway
kegghsa04340Hedgehog signaling pathway - Homo sapiens (human)
kegghsa04390Hippo signaling pathway - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05217Basal cell carcinoma - Homo sapiens (human)
pidhedgehog_2pathwaySignaling events mediated by the Hedgehog family
pidhedgehog_glipathwayHedgehog signaling events mediated by Gli proteins
netpathPathway_HedgehogHedgehog
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-5358351Signaling by Hedgehog
reactomeR-HSA-5358351Signaling by Hedgehog
reactomeR-HSA-5610783Degradation of GLI2 by the proteasome
reactomeR-HSA-5610787Hedgehog 'off' state
reactomeR-HSA-5610787Hedgehog 'off' state
reactomeR-HSA-5632684Hedgehog 'on' state
reactomeR-HSA-5635851GLI proteins bind promoters of Hh responsive genes to promote transcription
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878166Transcriptional regulation by RUNX2
reactomeR-HSA-8941284RUNX2 regulates chondrocyte maturation
reactomeR-HSA-8941326RUNX2 regulates bone development

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD144NSC953975
iGMDRD427ABT7373
iGMDRD483SCH-5290741
iGMDRD1008SR-II-138A2
iGMDRD579PF7503
iGMDRD420Leucascandrolide A2
iGMDRD599Salermide3
iGMDRD394BX-7956
iGMDRD280CYTOCHALASIN B3
iGMDRD359OSW-12
iGMDRD446LY 21832402
iGMDRD152179324-69-72
iGMDRD639YK 4-2792
iGMDRD52Rotenone5
iGMDRD885Compound 1105
iGMDRD270Ciclosporin2
iGMDRD513BML-2591
iGMDRD255SB2250023
iGMDRD524ISX-93
iGMDRD356PNU-746542
iGMDRD730Kahalalide F2
iGMDRD188Piperlongumine3
iGMDRD562Navitoclax5
iGMDRD577BIX012948
iGMDRD424Tamatinib2
iGMDRD652UNC06382
iGMDRD701NVP-AUY9222
iGMDRD523Cyanoquinoline, 113
iGMDRD584VER 1550081
iGMDRD512nutlin 33
iGMDRD123Isoevodiamine4
iGMDRD901ELCPK3
iGMDRD85Ursolic acid2
iGMDRD341Triacsin c2
iGMDRD698Neratinib3
iGMDRD57Chloropentafluorobenzene5
iGMDRD705Nakiterpiosin1
iGMDRD105Triptolide2
iGMDRD1006SMO inhibitor1
iGMDRD231Importazole1
iGMDRD267Oligomycin A2
iGMDRD77Itraconazole3
iGMDRD481Dactolisib2
iGMDRD505Pevonedistat5
iGMDRD286Nsc 6328391
iGMDRD871BRD63686
iGMDRD329Merck605

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GLI2

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