CYSLTR2
Summary: The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cysteinyl leukotriene receptor 2 | MIM:605666 | Ensembl:ENSG00000152207 | HGNC:HGNC:18274 | PA38518 | 13q14.2 |
GO terms in CYSLTR2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0001631 | cysteinyl leukotriene receptor activity |
| MF | IBA | GO:0004966 | galanin receptor activity |
| MF | NAS | GO:0004974 | leukotriene receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008528 | G-protein coupled peptide receptor activity |
| CC | ND | GO:0005575 | cellular_component |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| BP | NAS | GO:0006955 | immune response |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IBA | GO:0007188 | adenylate cyclase-modulating G-protein coupled receptor signaling pathway |
| BP | IBA | GO:0007218 | neuropeptide signaling pathway |
| BP | IEA | GO:0010942 | positive regulation of cell death |
| BP | IEA | GO:0045766 | positive regulation of angiogenesis |
| BP | IEA | GO:0061737 | leukotriene signaling pathway |
| BP | IEA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
Gene expression in normal tissue: CYSLTR2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CYSLTR2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-391903 | Eicosanoid ligand-binding receptors |
| reactome | R-HSA-391906 | Leukotriene receptors |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-500792 | GPCR ligand binding |
| biocarta | eicosanoidpathway | eicosanoid metabolism |
| pid | endothelinpathway | Endothelins |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| wikipathways | WP3624 | Lung fibrosis |
| wikipathways | WP455 | GPCRs, Class A Rhodopsin-like |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD481 | Dactolisib | 3 |
| iGMDRD226 | ML006 | 3 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD885 | Compound 110 | 6 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD524 | ISX-9 | 6 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD359 | OSW-1 | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CYSLTR2
CLASSFICATION
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