CYSLTR2

Summary: The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namecysteinyl leukotriene receptor 2
OMIM IDMIM:605666
Ensembl IDEnsembl:ENSG00000152207
HGNC IDHGNC:HGNC:18274
PHARMGKB IDPA38518
Map Location13q14.2

GO terms in CYSLTR2


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0001631 cysteinyl leukotriene receptor activity
MF IBA GO:0004966 galanin receptor activity
MF NAS GO:0004974 leukotriene receptor activity
MF IPI GO:0005515 protein binding
MF IBA GO:0008528 G-protein coupled peptide receptor activity
CC ND GO:0005575 cellular_component
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Gene expression in normal tissue: CYSLTR2

Gene-model tissue-cancer distribution: Bubble Plot

BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 5undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 18LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 23

Gene-drug pathway distribution

undefined11IGFR signaling1ERK MAPK signaling1Apoptosis regulation1PI3K/MTOR signaling1Chromatin histone acetylation1

Pathways in CYSLTR2


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Database
Pathway ID
Pathway Des.
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-372790 Signaling by GPCR
reactome R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
reactome R-HSA-388396 GPCR downstream signalling
reactome R-HSA-391903 Eicosanoid ligand-binding receptors
reactome R-HSA-391906 Leukotriene receptors
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD481 Dactolisib 3
iGMDRD226 ML006 3
iGMDRD318 PAC-1 1
iGMDRD885 Compound 110 6
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CYSLTR2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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