CD44


Summary: The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in CD44


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0004888 transmembrane signaling receptor activity
MF IBA GO:0004896 cytokine receptor activity
MF IDA GO:0004896 cytokine receptor activity
MF IPI GO:0005515 protein binding
MF NAS GO:0005518 collagen binding
MF IBA GO:0005540 hyaluronic acid binding
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Gene expression in normal tissue: CD44

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CD44


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Database
Pathway ID
Pathway Des.
reactome R-HSA-109582 Hemostasis
reactome R-HSA-1280215 Cytokine Signaling in Immune system
reactome R-HSA-1430728 Metabolism
reactome R-HSA-1474228 Degradation of the extracellular matrix
reactome R-HSA-1474244 Extracellular matrix organization
reactome R-HSA-1630316 Glycosaminoglycan metabolism
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD634 SCHEMBL2608041 4
iGMDRD353 PD0325901 2
iGMDRD945 ML214 4
iGMDRD297 Austocystin D 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CD44

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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