Summary: The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008].

CD44 molecule (Indian blood group)MIM:107269Ensembl:ENSG00000026508HGNC:HGNC:1681PA2622111p13

GO terms in CD44

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004888transmembrane signaling receptor activity
MFIBAGO:0004896cytokine receptor activity
MFIDAGO:0004896cytokine receptor activity
MFIPIGO:0005515protein binding
MFNASGO:0005518collagen binding
MFIBAGO:0005540hyaluronic acid binding
MFIDAGO:0005540hyaluronic acid binding
MFNASGO:0005540hyaluronic acid binding
BPIBAGO:0006954inflammatory response
BPIBAGO:0007155cell adhesion
BPNASGO:0007160cell-matrix adhesion
BPIBAGO:0007166cell surface receptor signaling pathway
BPTASGO:0022617extracellular matrix disassembly
BPTASGO:0030198extracellular matrix organization
BPIDAGO:0030214hyaluronan catabolic process
BPTASGO:0030214hyaluronan catabolic process
BPIDAGO:0033138positive regulation of peptidyl-serine phosphorylation
BPIMPGO:0034116positive regulation of heterotypic cell-cell adhesion
BPIMPGO:0043066negative regulation of apoptotic process
BPIMPGO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
BPTASGO:0043312neutrophil degranulation
BPIDAGO:0043518negative regulation of DNA damage response, signal transduction by p53 class mediator
BPIMPGO:0044319wound healing, spreading of cells
BPIDAGO:0044344cellular response to fibroblast growth factor stimulus
BPIDAGO:0050731positive regulation of peptidyl-tyrosine phosphorylation
BPTASGO:0050900leukocyte migration
BPIEPGO:0051216cartilage development
BPTASGO:0060333interferon-gamma-mediated signaling pathway
BPIBAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIDAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIMPGO:0070487monocyte aggregation
BPNASGO:0098609cell-cell adhesion
BPIMPGO:1900625positive regulation of monocyte aggregation
BPIDAGO:1902166negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
BPIMPGO:2000392regulation of lamellipodium morphogenesis
CCIDAGO:0005794Golgi apparatus
CCIBAGO:0005886plasma membrane
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCNASGO:0005887integral component of plasma membrane
CCHDAGO:0005925focal adhesion
CCIDAGO:0009986cell surface
CCIBAGO:0016323basolateral plasma membrane
CCIDAGO:0016324apical plasma membrane
CCTASGO:0030667secretory granule membrane
CCIDAGO:0031258lamellipodium membrane
CCIBAGO:0035692macrophage migration inhibitory factor receptor complex
CCIDAGO:0035692macrophage migration inhibitory factor receptor complex
CCIDAGO:0042995cell projection
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: CD44

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CD44

DatabasePathway IDPathway Des.
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1474228Degradation of the extracellular matrix
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1630316Glycosaminoglycan metabolism
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-202733Cell surface interactions at the vascular wall
reactomeR-HSA-2142845Hyaluronan metabolism
reactomeR-HSA-216083Integrin cell surface interactions
reactomeR-HSA-2160916Hyaluronan uptake and degradation
reactomeR-HSA-6798695Neutrophil degranulation
reactomeR-HSA-71387Metabolism of carbohydrates
reactomeR-HSA-877300Interferon gamma signaling
reactomeR-HSA-913531Interferon Signaling
pidavb3_opn_pathwayOsteopontin-mediated events
kegghsa04512ECM-receptor interaction - Homo sapiens (human)
kegghsa04640Hematopoietic cell lineage - Homo sapiens (human)
kegghsa05131Shigellosis - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
wikipathwaysWP3646Hepatitis C and Hepatocellular Carcinoma
wikipathwaysWP399Wnt Signaling Pathway and Pluripotency
wikipathwaysWP615Senescence and Autophagy in Cancer

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD297Austocystin D1
iGMDRD889Compound 7d-cis1
iGMDRD523Cyanoquinoline, 112

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CD44